1.Report on HbA(1c) Proficiency Testing in Asia in 2012.
Masao UMEMOTO ; Tadao HOSHINO ; Tetsuo MIYASHITA ; Wataru TANI ; Katsuhiko KUWA
Annals of Laboratory Medicine 2015;35(3):352-355
In 2010, the Japan Diabetes Society decided to introduce the National Glycohemoglobin Standardization Program (NGSP) values into clinical practice. Accordingly, NGSP Certification of Japanese manufacturers of HbA(1c)-related diagnostic reagents and instruments was initiated in February, 2012, through an NGSP network laboratory, the Asian Secondary Reference Laboratory (ASRL) #1. Traceability to the NGSP reference system can be endorsed by manufacturer certification, as well as by the College of American Pathologists (CAP) survey. Nevertheless, only a few manufacturers participate in the CAP survey in Japan. Thus, proficiency testing (PT) was proposed and executed by ASRL #1. Single-donor whole-blood samples were used for the PT. The participated measurement systems were NGSP certified. Twenty-two laboratories obtained certification through ASRL #1; 2 through the Secondary Reference Laboratory (SRL) #8; and 9 through the SRL #9. The combination plots of the bias data in this PT and in the NGSP certification performed in March and May in 2012 were consistent with each other: mean NGSP values at each level agreed well with the target value. In conclusion, PT using whole blood is useful in endorsing NGSP certification.
Asia
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Chromatography, High Pressure Liquid
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Enzyme Assays
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Hemoglobin A, Glycosylated/*analysis/standards
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Humans
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Immunoassay
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Japan
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Laboratory Proficiency Testing/*standards
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Quality Control
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Reference Standards
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Republic of Korea
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Societies, Scientific
2.Contribution of Visceral Fat Accumulation to Metabolic and Vascular Complications in Obesity.
Tsuneo OHNO ; Keisuke ITOH ; Wataru MURAMATSU ; Tomomitsu TANI ; Fuminori OKUMURA ; Yoshiaki YAMADA ; Kunio KASUGAI ; Toshiaki SHIGEYASU ; Takashi MONOE ; Kouji NAGAHARA
Journal of the Japanese Association of Rural Medicine 1995;44(4):592-596
In patients with the visceral fat type obesity, there is a high incidence of glucose and lipid metabolic abnormalities and hypertension. We obtained the following results from a study of the relationship between the degree of visceral fat obesity and metabolic and vascular complications in 98 obese patients with various complications.
1. Viceral fat obesity (V/S ratio ≥ 0.4) was found in 74% of the subjects. The incidence was higher in males than females. The highest incidence was observed in both men and women in thier 40s, and there was no increase with age.
2. The V/S ratio was high in patients with hyperlipidemia, diabetes, and fatty liver in that order. In the V/S ≥ 0.4 group, there was a higher incidence of hyperlipidemia and ischemic heart disease than in the V/S<0.4 group.
3. The V/S ratio was higher in the patients with two or more metabolic and vascular complications than in those with only one complication.
4. A questionnaire survey showed that there were many individuals who did almost no exercise and had a long history of obesity in the V/S ≥ 0.4 group.
5. The V/S ≥ 0.4 group had high triglyceride levels. There was a positive correlation between the V/ S ratio or V value and the trigyceride level, but no correlation between S value and triglyceride level.