In this study, we examined the relationship between physical function and muscle strain of hamstrings in junior high school soccer players. The subjects were 29 junior high school soccer players. The muscle strength of knee flexors and extensors relative to body weight and the hamstrings/quadriceps muscle strength ratio (H/Q ratio) were measured, and a tightness test, general joint looseness test and the New Physical Fitness Test of Japanese Ministry of Education and science were performed. We contacted the trainer to confirm occurrence of hamstrings strain, and we compared the above measurement and test results in subjects with and those without hamstring strain. Differences were analyzed by the unpaired t-test. There were significant differences between the two groups in muscle strength of knee extensors, H/Q ratio and tightness of hamstrings (p<0.05). The results suggest that increasing the H/Q ratio and stretching hamstrings are important for preventing hamstrings strain in junior high school soccer players.

Fecal microbiota transplantation (FMT) has been reported as a safe and effective therapy in patients with refractory and recurrent Clostridium difficile infection (CDI). FMT has also been reported as a promising therapy in patients with ulcerative colitis (UC). Both, CDI and UC, are believed to be caused by dysbiosis, such as altered compositions or decreased diversity of the intestinal microbiota. This report describes a patient with UC in remission with a second recurrent episode of CDI, who was treated with FMT. A single FMT performed via colonoscopy completely resolved the patient's diarrhea and eradicated C. difficile bacteriologically without any severe complications. Molecular biological analysis of the patient's fecal microbiota showed that FMT could dramatically change the altered composition of intestinal microbiota and restore its diversity. Despite the restoration of the intestinal microbiota, FMT could not prevent a relapse of UC in this patient. However, it improved the intestinal symptoms of CDI and could prevent further recurrences of CDI.
Clostridium difficile ; Clostridium ; Colitis, Ulcerative ; Colonoscopy ; Diarrhea ; Dysbiosis ; Fecal Microbiota Transplantation ; Gastrointestinal Microbiome ; Humans ; Microbiota ; Recurrence ; Ulcer

Objective：This study aimed to determine the difference in knee joint range of motion (ROM) and coefficient of variation (CV) during preoperative single-leg squatting in patients who developed ipsilateral lower limb anterior cruciate ligament (ACL) re-injury months after ACL reconstruction and in those who did not have the injury.Methods：Participants included 38 patients with non-contact ACL injuries. All patients underwent single-leg squatting the day before ACL reconstruction. Knee joint ROM and CV were assessed during single-leg squatting using a three-dimensional motion analysis system. We investigated the occurrence of ACL reinjury in the ipsilateral lower limb approximately 30 months after ACL reconstruction. Knee joint ROM and CV were then compared between the postoperative and non-injury groups.Results：The postoperative injury and non-injury groups included 9 and 29 patients, respectively. The knee internal/external rotation ROM and CV of knee varus/valgus ROM were greater in the postoperative injury group than in the postoperative non-injury group.Conclusion：During single-leg squatting before ACL reconstruction surgery, the knee internal/external rotation ROM and CV of knee varus/valgus ROM were suggested to be points of evaluation when considering ACL re-injury prevention.

Objective：This study aimed to determine the difference in knee joint range of motion (ROM) and coefficient of variation (CV) during preoperative single-leg squatting in patients who developed ipsilateral lower limb anterior cruciate ligament (ACL) re-injury months after ACL reconstruction and in those who did not have the injury.Methods：Participants included 38 patients with non-contact ACL injuries. All patients underwent single-leg squatting the day before ACL reconstruction. Knee joint ROM and CV were assessed during single-leg squatting using a three-dimensional motion analysis system. We investigated the occurrence of ACL reinjury in the ipsilateral lower limb approximately 30 months after ACL reconstruction. Knee joint ROM and CV were then compared between the postoperative and non-injury groups.Results：The postoperative injury and non-injury groups included 9 and 29 patients, respectively. The knee internal/external rotation ROM and CV of knee varus/valgus ROM were greater in the postoperative injury group than in the postoperative non-injury group.Conclusion：During single-leg squatting before ACL reconstruction surgery, the knee internal/external rotation ROM and CV of knee varus/valgus ROM were suggested to be points of evaluation when considering ACL re-injury prevention.

Background/Aims: 5-Aminosalicylic acid (ASA) causes intolerance reactions in some patients. This study was performed to examine the prognosis of patients with ulcerative colitis (UC) and 5-ASA intolerance, and to evaluate the potential interaction between 5-ASA intolerance and the intestinal microbiota. Methods: We performed a retrospective cohort study of patients with UC who visited participating hospitals. The primary endpoint was to compare the incidence of hospitalization within 12 months between the 5-ASA intolerance group and the 5-ASA tolerance group. The secondary endpoint was to compare the risk of adverse clinical outcomes after the start of biologics between the 2 groups. We also assessed the correlation between 5-ASA intolerance and microbial change in an independently recruited cohort of patients with UC. Results: Of 793 patients, 59 (7.4%) were assigned to the 5-ASA intolerance group and 734 (92.5%) were assigned to the 5-ASA tolerance group. The admission rate and incidence of corticosteroid use were significantly higher in the intolerance than tolerance group (P< 0.001). In 108 patients undergoing treatment with anti-tumor necrosis factor biologics, 5-ASA intolerance increased the incidence of additional induction therapy after starting biologics (P< 0.001). The 5-ASA intolerance group had a greater abundance of bacteria in the genera Faecalibacterium, Streptococcus, and Clostridium than the 5-ASA tolerance group (P< 0.05). Conclusions In patients with UC, 5-ASA intolerance is associated with a risk of adverse clinical outcomes and dysbiosis. Bacterial therapeutic optimization of 5-ASA administration may be important for improving the prognosis of patients with UC.

The case is that of a 90-years-old man. A previous doctor performed abdominal graft replacement for an abdominal aortic aneurysm 5 years earlier and continued outpatient CT follow-up. Follow-up CT showed the right aortic arch and dilation of the thoracic aortic aneurysm, and the patient was referred to our hospital. Contrast-enhanced CT showed an aortic arch aneurysm ; the aneurysm diameter was 62 mm in major axis and 60 mm in minor axis, which was judged to be suitable for surgery. It was a rare right-sided aortic arch with no congenital heart malformation and no situs inversus. Endovascular treatment was considered because he was 90 years old and very elderly, but there were concerns about the risk of embolism, irregular manipulation and central landing. For the surgical method, we selected total arch replacement using a frozen elephant trunk technique. We succeeded in avoiding serious complications by selecting an appropriate treatment method through careful evaluation.