OBJECTIVE:To investigate the clinical efficacy and safety of modified Bazhen decoction combined with antibiot-ics in the treatment of postpartum fever with qi-blood deficiency. METHODS:Totally 94 cases of postpartum fever with qi-blood deficiency selected from our hospital during Dec. 2014-Jun. 2016 were divided into control group and observation group according to random number table,with 47 cases in each group. Control group was given Cefazolin sodium for injection 3 g added into Sodi-um chloride injection 250 mL,ivgtt,bid;and given Azithromycin for injection 250 mg added into Sodium chloride injection 250 mL,ivgtt,bid if body temperature did not drop for consecutive 2 days;the patients with body temperature over 38.5 ℃ were giv-en Compound aminophenazone and barbital injection 2 mL intramuscularly. Observation group was additionally given modified Ba-zhen decoction on the basis of control group. Treatment course of 2 groups lasted for 5 d. Clinical efficacies were compared be-tween 2 groups as well as white blood cell count,plasma C reactive protein(CRP),plasma viscosity and fibrinogen(Fib)before and after treatment. The antipyretic time,hospitalization time and the occurrence of ADR were observed in 2 groups. RESULTS:The total response rate of observation group was 95.75%,which was significantly higher than 78.72%of control group,with statis-tical significance(P<0.05). Before treatment,there was no statistical significance in white blood cell count,CRP,plasma viscosi-ty or Fib between 2 groups(P>0.05). After treatment,white blood cell count,CRP,plasma viscosity and Fib of 2 groups were decreased significantly,and the observation group was significantly lower than the control group,with statistical significance(P<0.05). The antipyretic time and hospitalization time of observation group were shorter than those of control group,with statistical significance (P<0.05). The incidence of ADR in observation group was 6.38%,which was significantly lower than 23.40% of control group,with statistical significance (P<0.05). CONCLUSIONS:Modified Bazhen decoction combined with antibiotics in the treatment of postpartum fever with qi-blood deficiency can significantly improve inflammation status and plasma viscosity,and speed up defervescence with good safety.