1.Role of gut microbiota in the pathogenesis and treatment of chronic kidney disease
Yangyang ZHANG ; Jiayuan HUANG ; Shan JIANG ; Wanying KANG ; Wenjing ZHAO ; Zhihua ZHENG
Chinese Journal of Nephrology 2023;39(9):722-728
Chronic kidney disease (CKD) is a serious health problem worldwide, whereas there is still no efficient cure. The gut microbiota plays a crucial role in maintaining human health and disease resistance, and multiple studies have confirmed that the gut microbiota is closely related to the occurrence and development of CKD. Starting from the "gut-kidney axis" theory, this article provides a systematic review of the changes in gut microbiota composition and function in patients with CKD, such as a decrease in the abundance of butyrate-producing bacteria Roseburia and Faecalibacterium prausnitzii. Besides that, the article explores the mechanisms by which the gut microbiota affects CKD progression, such as inflammation and immunity, and also describes the application methods of using the gut microbiota as a therapeutic target for CKD, such as fecal microbiota transplantation, microecologics, and dietary therapy, in order to provide microbial- based targets for the clinical diagnosis and treatment of CKD.
2. Association of sleep with anxiety in the elderly aged 60 years and older in China
Wanying SHI ; Minghao GUO ; Peng DU ; Yi ZHANG ; Jiaonan WANG ; Tiantian LI ; Yuebin LYU ; Jinhui ZHOU ; Jun DUAN ; Qi KANG ; Xiaoming SHI
Chinese Journal of Epidemiology 2020;41(1):13-19
Objective:
To investigate the relationship of sleep duration and sleep quality with anxiety in the elderly aged 60 years and older in China.
Methods:
The elderly aged 60 years and older were selected from the China Short-term Health Effects of Air Pollution Study conducted between July 18, 2017 and February 7, 2018. Multivariate logistic regression models were used to analyze the association of sleep duration and sleep quality with anxiety.
Results:
A total of 3 897 elderly aged 60 years and older were included in the study. The age of the elderly was (73.4±8.0) years old. Among the elderly surveyed, 6.5
3. Influencing factors for depressive symptoms in the elderly aged 65 years and older in 8 longevity areas in China
Qi KANG ; Yuebin LYU ; Yuan WEI ; Wanying SHI ; Jun DUAN ; Jinhui ZHOU ; Jiaonan WANG ; Feng ZHAO ; Yingli QU ; Ling LIU ; Yingchun LIU ; Zhaojin CAO ; Qiong YU ; Xiaoming SHI
Chinese Journal of Epidemiology 2020;41(1):20-24
Objective:
To analyze influencing factors for depressive symptoms in the elderly aged 65 years and older in 8 longevity areas in China.
Methods:
We recruited 2 180 participants aged 65 years and older in 8 longevity areas from Healthy Aging and Biomarkers Cohort Study, a sub-cohort of the Chinese Longitudinal Healthy Longevity Survey in 2017. Multivariate logistic regression analysis was performed to evaluate the relationships of socio-demographic characteristics, behavioral lifestyle, chronic disease prevalence, functional status, family and social support with depressive symptoms in the elderly.
Results:
The detection rate of depression symptoms was 15.0
4. Prediction of 6-year incidence risk of chronic kidney disease in the elderly aged 65 years and older in 8 longevity areas in China
Jinhui ZHOU ; Yuan WEI ; Yuebin LYU ; Jun DUAN ; Qi KANG ; Jiaonan WANG ; Wanying SHI ; Zhaoxue YIN ; Feng ZHAO ; Yingli QU ; Ling LIU ; Yingchun LIU ; Zhaojin CAO ; Xiaoming SHI
Chinese Journal of Epidemiology 2020;41(1):42-47
Objective:
To establish a prediction model for 6-year incidence risk of chronic kidney disease (CKD) in the elderly aged 65 years and older in China.
Methods:
In this prospective cohort study, we used the data of 3 742 participants collected during 2008/2009-2014 and during 2012-2017/2018 from Healthy Aging and Biomarkers Cohort Study, a sub-cohort of the Chinese Longitudinal Healthy Longevity Survey. Two follow up surveys for renal function were successfully conducted for 1 055 participants without CKD in baseline survey. Lasso method was used for the selection of risk factors. The risk prediction model of CKD was established by using Cox proportional hazards regression models and visualized through nomogram tool. Bootstrap method (1 000 resample) was used for internal validation, and the performance of the model was assessed by C-index and calibration curve.
Results:
The mean age of participants was (80.8±11.4) years. In 4 797 person years of follow up, CKD was found in 262 participants (24.8
5.Correlations Between Single Nucleotide Polymorphisms, Cognitive Dysfunction, and Postmortem Brain Pathology in Alzheimer's Disease Among Han Chinese.
Qian YANG ; Kang CHEN ; Hanlin ZHANG ; Wanying ZHANG ; Changlin GONG ; Qing ZHANG ; Pan LIU ; Tianyi SUN ; Yuanyuan XU ; Xiaojing QIAN ; Wenying QIU ; Chao MA
Neuroscience Bulletin 2019;35(2):193-204
In this study, the distribution of five Alzheimer's disease (AD)-related single nucleotide polymorphisms (SNPs) in the Han population was examined in combination with the evaluation of clinical cognition and brain pathological analysis. The associations among SNPs, clinical daily cognitive states, and postmortem neuropathological changes were analyzed in 110 human brains from the Chinese Academy of Medical Sciences/Peking Union Medical College (CAMS/PUMC) Human Brain Bank. APOE ε4 (OR = 4.482, P = 0.004), the RS2305421 GG genotype (adjusted OR = 4.397, P = 0.015), and the RS10498633 GT genotype (adjusted OR = 2.375, P = 0.028) were associated with a higher score on the ABC (Aβ plaque score, Braak NFT stage, and CERAD neuritic plaque score) dementia scale. These results advance our understanding of the pathogenesis of AD, the relationship between pathological diagnosis and clinical diagnosis, and the SNPs in the Han population for future research.
ADAM10 Protein
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genetics
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Adult
;
Aged
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Aged, 80 and over
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Alzheimer Disease
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genetics
;
pathology
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Amyloid Precursor Protein Secretases
;
genetics
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Antiporters
;
genetics
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Apolipoprotein E4
;
genetics
;
Asian Continental Ancestry Group
;
genetics
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Brain
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pathology
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Cognitive Dysfunction
;
genetics
;
pathology
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Female
;
Genetic Predisposition to Disease
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Humans
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Male
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Membrane Proteins
;
genetics
;
Middle Aged
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Polymorphism, Single Nucleotide