Objective To investigate the prevention effect of advanced nursing intervention on constipation in the patients with hypertensive cerebral hemorrhage after minimally invasive surgery. Methods A total of 120 patients who suffered hypertensive cerebral hemorrhage were randomly divided into the observation group(n = 80)and the control group(n = 40). The patients of observation group received advanced nursing intervention immediately after minimally invasive surgery,and the patients of control group received conventional care. The defecation score,the ideal stool form of Bristol stool character classification and incidence of constipation were compared between two groups. Results Two weeks after intervention,the defecation score of observation group dropped from(2. 47 ± 0. 48)to(0. 96 ± 0. 49),and that of control group declined from (2. 45 ± 0. 51)to(2. 05 ± 0. 60)with statistical significance between before and after intervention in two groups (t = 2. 72,P < 0. 01). The ideal stool form of Bristol stool character classification risen from 13. 8% to 75. 0%in observation group and from 12. 5% to 20. 0% in the control group(P < 0. 01). The incidence of constipation in observation group was 25. 0% ,and the incidence of constipation in control group was 80. 0% after intervention(χ2 = 32. 85,P < 0. 01). Conclusions The advanced nursing intervention can effectively prevent the occurrence of constipation in the patients with hypertension cerebral hemorrhage after minimally invasive surgery. It can avoid or reduce complications and its serious consequences caused by constipation. This method is worth of clinical application.