Objective:To systematically review the disease experience of hemophilia patients, so as to provide a basis for formulating precise intervention plans.Methods:Qualitative studies on the disease experience of hemophilia patients were searched through computers in PubMed, Embase, Scopus, Web of Science, Cochrane Library, China Biomedical Literature Database, China National Knowledge Infrastructure, WanFang Data, and VIP. The search period was from the establishment of the database to June 28, 2023. The quality of article was evaluated using the quality evaluation criteria for qualitative research of the Joanna Briggs Institute Evidence-Based Health Care Center. The aggregation integration method was used to summarize and integrate the results.Results:A total of 14 articles were included. 58 research results were extracted and categorized into 13 categories, with 4 integrated results, including emotional experience of disease, coping strategies for illness, the impact of disease on daily life and breaking life norms, the influencing factors of disease treatment and management.Conclusions:The government, relevant departments, medical institutions, and families should pay attention to the emotional behavior of patients, guide them to actively respond to diseases, attach importance to their daily life to alleviate their life pressure, strengthen disease knowledge popularization to improve social disease cognition, increase treatment accessibility, and optimize treatment and nursing.