1.Clinical diagnostic value of plasma homocysteine in the prognosis of patients with acute cerebral infarction
Liyan SONG ; Jiafan TANG ; Yi ZHOU ; Wanqing ZHAI
Journal of Clinical Medicine in Practice 2014;(7):17-19,23
Objective To explore the clinical diagnostic value of plasma homocysteine (Hcy)in the prognosis of patients with acute cerebral infarction (ACI).Methods According to Hcy median value on admission,78 ACI patients with hyperhomocysteinemia were divided into high-Hcy group and low-Hcy group,and meanwhile 34 ACI patients with normal Hcy level were de-signed as control group.All patients were given the secondary prevention for cerebrovascular dis-ease.On the basis of conventional therapy,high-Hcy group and low-Hcy group were treated with vitamin B12.BI and NIHSS scores were respectively evaluated,and Hcy level was detected in 3 groups on first day of admission and 21st day of treatment,and the clinical efficiency was compared between high-Hcy group and low-Hcy group.Results Hcy levels in high-Hcy group and low-Hcy group decreased significantly on 21st day of treatment.Hcy levels in high-Hcy grouy and low-Hcy group were significantly higher than control group on first day of admission and 21st day of treat-ment,and the increasing range in high-Hcy group was even larger.NIHSS scores decreased,while BI scores increased significantly in 3 groups on 21st day of treatment.NIHSS scores in high-Hcy group and low-Hcy group were significantly higher than control group on first day of admission and 21st day of treatment,while BI scores were lower,and the increasing and decreasing ranges in high-Hcy group were even larger.The overall response rate of low-Hcy group was superior to high-Hcy group.Conclusion Detecting Hcy level can predict the prognosis of patients with ACI,and reduc-ing Hcy level can improve the neural functional defects and life capability of patients.
2.Clinical diagnostic value of plasma homocysteine in the prognosis of patients with acute cerebral infarction
Liyan SONG ; Jiafan TANG ; Yi ZHOU ; Wanqing ZHAI
Journal of Clinical Medicine in Practice 2014;(7):17-19,23
Objective To explore the clinical diagnostic value of plasma homocysteine (Hcy)in the prognosis of patients with acute cerebral infarction (ACI).Methods According to Hcy median value on admission,78 ACI patients with hyperhomocysteinemia were divided into high-Hcy group and low-Hcy group,and meanwhile 34 ACI patients with normal Hcy level were de-signed as control group.All patients were given the secondary prevention for cerebrovascular dis-ease.On the basis of conventional therapy,high-Hcy group and low-Hcy group were treated with vitamin B12.BI and NIHSS scores were respectively evaluated,and Hcy level was detected in 3 groups on first day of admission and 21st day of treatment,and the clinical efficiency was compared between high-Hcy group and low-Hcy group.Results Hcy levels in high-Hcy group and low-Hcy group decreased significantly on 21st day of treatment.Hcy levels in high-Hcy grouy and low-Hcy group were significantly higher than control group on first day of admission and 21st day of treat-ment,and the increasing range in high-Hcy group was even larger.NIHSS scores decreased,while BI scores increased significantly in 3 groups on 21st day of treatment.NIHSS scores in high-Hcy group and low-Hcy group were significantly higher than control group on first day of admission and 21st day of treatment,while BI scores were lower,and the increasing and decreasing ranges in high-Hcy group were even larger.The overall response rate of low-Hcy group was superior to high-Hcy group.Conclusion Detecting Hcy level can predict the prognosis of patients with ACI,and reduc-ing Hcy level can improve the neural functional defects and life capability of patients.
3.Analysis of Disease Burden and Attributable Risk Factors of Early-onset Female Breast Cancer in China and Globally from 1990 to 2021
Danqi HUANG ; Min YANG ; Wei XIONG ; Jingyi LIU ; Wanqing CHEN ; Jingbo ZHAI ; Jiang LI
Medical Journal of Peking Union Medical College Hospital 2025;16(3):777-784
To analyze the disease burden, temporal trends, and attributable risk factors of early-onset female breast cancer (EOBC) in China and globally from 1990 to 2021. Data on the absolute numbers and crude rates of incidence, mortality, and disability-adjusted life years (DALYs) for EOBC (diagnosis age < 50 years) in China and globally were extracted from the Global Burden of Disease (GBD) 2021 database. Attributable DALY proportions for five risk factors (smoking, alcohol use, physical inactivity, high red meat consumption, elevated fasting plasma glucose) and all combined risk factors were obtained. Joinpoint regression analysis was performed to assess temporal trends in age-standardized rates, quantified by annual percentage change (APC) and average annual percentage change (AAPC). From 1990 to 2021, age-standardized incidence rates of EOBC increased significantly in both China (AAPC=2.25%) and globally (AAPC=0.64%; pairwise comparison, China's age-standardized EOBC incidence is rising rapidly and approaching global levels, while mortality and DALY rates have increased over the past decade, underscoring persistent challenges in disease control. Future efforts should prioritize expanding the coverage of breast cancer screening programs, optimizing screening protocols, and enhancing public awareness of cancer prevention to mitigate the growing burden of EOBC in China.
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