Objective To study and analyze the effect of quinolones combined with psychological intervention on the patients with urinary tract infection. Methods 100 patients with urinary tract infection in Jiande the first people's hospital from January 2015 to December 2016 were selected as the the study subjects. They were randomly divided into two groups, the control group and the experimental group, 50 cases in each group. The control group were given Ceftezole sodium and other cephalosporins drug treatment, patients in the experimental group were ciprofloxacin treatment, two patients underwent renal protection, treatment for 12 cycles. The therapeutic effects in the experimental group and the control group were compared and analyzed. Results In the experimental group, 47 cases was effective, the effective rate was 94.0％;In the control group, 37 cases was effective, and the effective rate was 74.0％. The effective rate in the experimental group was significantly higher than that in the control group(P<0.05). The adverse reaction rate in the experiment group was 2％(1/50), and 4％(2/50) in the control group, the difference was no statistically significant. Conclusion The combination of quinolones and psychological intervention on the treatment of the patients with urinary tract infection is effective, which can can significantly improve the efficiency of treatment of infection, high safety.

Objective: To assess the interobserver variations in delineating the planning target volume (PTV) and organs at risk (OAR) using different contouring methods during intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC), aiming to provide references for the quality control of multi-center clinical trials. Methods: The PTV and OAR of CT image of 1 NPC patient manually delineated by 10 physicians from 8 different radiation centers were defined as the " manual contour group" , and the OAR auto-contoured using the ABAS software and modified by the physicians were defined as the " auto+ manual contour group" . The maximum/minimum ratio (MMR) of the PTV and OAR volumes, and the coefficient of variation (CV) for different delineated contours were comparatively evaluated. Results: Large variation was observed in the PTV and OAR volumes in the manual contour group. The MMR and CV of the PTV were 1.72-3.41 and 0.16-0.39, with the most significant variation in the PTV_nd (MMR=3.41 and CV=0.39 for the PTV_nd-L). The MMR and CV of the manually contoured OAR were 1.30-7.89 and 0.07-0.67. The MMR of the temporal lobe, spinal cord, temporomandibular joint, optic nerve and pituitary gland exceeded 2.0. Compared with the manual contour group, the average contouring time in the auto+ manual group was shortened by 68% and the interobserver variation of the OAR volume was reduced with an MMR of 1.04-2.44 and CV of 0.01-0.37. Conclusions Large variation may occur in the PTV and OAR contours during IMRT plans for NPC delineated by different clinicians from multiple medical centers. Auto-contouring+ manually modification can reduce the interobserver variation of OAR delineation, whereas the variation in the delineation of small organs remains above 1.5 times. The consistency of the PTV and OAR delineation and the possible impact upon clinical outcomes should be reviewed and evaluated in multi-center clinical trials.