Objective The aim is to provide drug regimen for patients who have hormone allergy history but need hor-mone therapy.Methods Pharmacists analyzed the sensitization mechanism of methylprednone in combination with insturction and literature,assisted clinicians to formulate oral hormone therapy for tuberculosis meningitis with history of menthylprednisolone and verified the effectiveness and safety of the drug regimen.Results Methylprednisolone injection contains trace amount of milk protein and should not be used in patients with definite allergy to cow's milk.After changing to oral hormone therapy,the patient did not appear allergic again,and the condition was stable.Conclusion Gucocorticoids can also induce allergic reactions,so patients'previous allergic history should be paid attention in the process of medical history collection.Meanwhile,pharmacists can also give full play to their pharmaceutical expertise to assist clinicians in formulating individualized drug administration plans to ensure the effectiveness and safety of patients.

Objective:To explore the anesthesia effect of dexmedetomidine combined with general anesthesia and superficial cervical plexus block in subtotal parathyroidectomy.Methods:A retrospective analysis was conducted on the medical records of 63 patients with secondary hyperparathyroidism (SHPT) in the anesthesia department of the People′s Hospital of Wuzhou from January 2021 to September 2022. According to different surgical anesthesia methods, the patients were divided into an observation group (dexmedetomidine combined with general anesthesia and superficial cervical plexus block, n=32) and a control group (general anesthesia and superficial cervical plexus block, n=31). Two groups of patients were compared in terms of perioperative hemodynamic indicators [heart rate (HR), diastolic blood pressure (SBP), systolic blood pressure (DBP), mean arterial pressure (MAP)], wake-up time and Stewards score of 5 points, total anesthetic dosage, blood glucose (BG) and norepinephrine (NE), and incidence of postoperative adverse reactions. Results:The HR, SBP, DBP, and MAP of the control group patients were significantly higher than those before anesthesia after tracheal intubation and tracheal extubation (all P<0.05), while there was no statistically significant difference in HR, SBP, DBP, and MAP between the observation group and before anesthesia after tracheal intubation and tracheal extubation (all P>0.05). The HR, SBP, DBP, and MAP of the observation group were significantly lower than those of the control group after tracheal intubation, during tracheal extubation, and at room departure (all P<0.05). The wake-up time and Stewards score of 5 points in the observation group were significantly shorter than those in the control group (all P<0.05). The dosage of propofol and remifentanil in the observation group was significantly lower than that in the control group ( P<0.05), and there was no statistically significant difference in the dosage of cisatracurium between the two groups ( P>0.05). The serum BG and NE levels in the observation group were significantly lower than those in the control group after tracheal intubation, during skin cutting, tracheal extubation, and during extubation (all P<0.05). The incidence of nausea, vomiting, and chills in the observation group was significantly lower than that in the control group (all P<0.05). Conclusions:The combination of dexmedetomidine with general anesthesia and superficial cervical plexus block is beneficial for stabilizing hemodynamics, inhibiting intraoperative stress response, reducing postoperative adverse reactions, and improving the quality of general anesthesia in patients with subtotal parathyroidectomy.

OBJECTIVETo evaluate the clinical value of the four regions 12-core systemic prostate biopsy.

METHODSNinety-one patients suspected of prostate cancer received four regions 12-core systemic prostate biopsy, and the detection rate and complications were compared with those of the sextant method.

RESULTSMore positive results were obtained in detecting prostate cancer with the four regions 12-core method, and the complications were similar to those of the sextant biopsy.

CONCLUSIONThe four regions 12-core biopsy was suggested for patients suspected of prostate cancer with enlarged prostate gland above 40 ml.

Aged ; Aged, 80 and over ; Biopsy, Needle ; adverse effects ; Humans ; Male ; Middle Aged ; Prostate ; pathology ; Prostatic Neoplasms ; diagnosis ; pathology

In recent years, with the endless emergence of meibomian gland dysfunction(MGD)diagnostic equipment, rich treatment methods, and in-depth clinical and basic research on MGD at home and abroad, the understanding of MGD has entered a new stage. MGD-related dry eye is considered to be the main cause of lipid abnormal dry eye, and its occurrence and development is a chronic and multi-factorial pathological process. This article reviews the pathogenesis, imaging analysis and clinical treatment progress of MGD-related dry eye, in order to provide scientific evidence and ideas for clinical diagnosis and therapy of MGD-related dry eye.