Systemic lupus erythematosus is a chronic autoimmune disease.The serology of many patients have changed a few years before the appearance of clinical symptoms,the autoantibody is not just caused by immunologic derangement,but also has relation with tissue lesions.Therefore,it is important to investigate the significance of auto-antibody.This article is aimed at summarizing the relationship between systemic lupus erythematosus and autoantibody.

ObjectiveTo evaluate the role of serum IgM, IgG and IgA anticardiolipin antibody (ACA) isotypes in the diagnosis of systemic lupus erythematosus (SLE), and their association with lupus nephritis (LN) in children.Methods One hundred and sixteen hospitalized SLE pediatric patients were selected between April 2005 and October 2013. The clinical data were collected and analyzed.Results There were 20 males and 96 females among 116 SLE patients. The positive rate of ACA-IgG, ACA-IgM and ACA-IgA was 37.1%, 35.3%, 26.7% respectively, without signiifcant difference between each other (P>0.05). Among 116 SLE patients, 75 cases had LN and 41 cases had no LN. The positive rates of ACA-IgM and ACA-IgA were not sig-niifcantly different between cases with and without LN (P>0.05). Cases with LN (42.7%) had higher ACA-IgG positive rate than cases without LN (22.0%) (P=0.026). The occurrence of LN and the positive rate of ACA isotypes were not signiifcantly different between genders (P>0.05).Conclusions The different isotypes of ACA have the same signiifcance in the diagnosis of SLE. The detection of ACA-IgG helps diagnose the LN complicated with SLE.

Objective To assess the value of cardiac magnetic resonance (CMR) imaging in left ventricular structure and function in patients with end stage renal disease (ESRD).Methods Twenty-five patients with ESRD and 10 healthy subjects underwent CMR.Left ventricular end diastolic volume(EDV),end-diastolic diameter(EDD),end-systolic volume(ESV),end-systolic diameter(ESD),stroke volume(SV),ejection fraction(EF),LVM and interventricular septum (IVS) thickness were measured and compared.The parameters from CMR and 2DTTE were compared.Results The EF in patients with ESRD was significantly lower than that in controls (P＜0.001),while ESV,ESD,IVS and LVM were respectively higher than these in controls (P＜0.05).There was no significant difference (P＞0.05) in ESV between CMR and 2DTTE,but EF of CMR was significantly higher than this of 2DTTE (P＜0.05).There was no significant difference (P =0.296) in left ventricular systolic functional category.Bland-Altman plots showed a good agreement between the two methods.Conclusion CMR is a helpful tool to assess left ventricular structure and function in patients with ESRD.

Lung cancer is one of the most common malignancies with the highest incidence rate and mortality rate worldwide, and non-small cell lung cancer (NSCLC) accounts for about 85%. Only 5% NSCLC patients are anaplastic lymphoma kinase (ALK) rearrangement positive NSCLC, but the prognosis of these patients is poor, and treatment is urgent. Ensartinib (X-396), a next-generation ALK tyrosine kinase inhibitor (ALK-TKI), has shown greater potency on inhibiting ALK activity and controlling brain metastases than crizotinib, which is indicated for the treatment of crizotinib-resistant, ALK-positive NSCLC patients. Several phase I to III clinical trials included both healthy volunteers and NSCLC patients have been conducted both in China and abroad. In this review, we briefly summarized the results of these trials, and preliminary efficacy, safety, pharmacology and pharmacokinetics/pharmacodynamics of ensartinib were discussed.