PURPOSE: The purpose of this study was to identify predictors influencing relational self and negative thinking on coping among teachers working with students with attention deficit hyperactivity disorder (ADHD). METHODS: A cross sectional study design was conducted with 212 teachers in six elementary schools located in D and C cities. Data were analyzed using t test, one way ANOVA, Pearson's correlation coefficients, and stepwise regression analysis with SPSS 18.0. RESULTS: The significant predictive factor for the active coping type was perceived support in relational self. Empathy care was as a significant factor for the passive coping type. Relationship avoidance and agency were significant predictive factors for negative coping with ADHD students. Active and passive coping had significant negative correlations with social worry. Significant factors for positive coping were attendance at ADHD workshops and number of years of teaching. CONCLUSION: Results suggest that it is important to focus on teachers having a positive aspect in the classroom, using new strategies, and understanding their own inner factors of perceived support and empathy care in order to provide positive coping and enhance relationships with ADHD students. To further enhance positive coping and perceived support and to reduce social worry, teachers should use community resources, especially psychiatric health nurses.
Adaptation, Psychological ; Anxiety ; Attention Deficit Disorder with Hyperactivity* ; Education ; Empathy ; Humans ; Self Psychology ; Thinking

BACKGROUND: Endothelial adhesion molecule expression induced by pro-inflammatory cytokine plays an important role in vascular endothelial cell injury, leading to vascular disease. Allium tuberosum (AT), which is used as a functional food, has a thrombolytic effect. It contains vitamin A, vitamin C, carbohydrate, calcium, iron, and phosphorus. There are many carotenes that turn into vitamin A in the body. Also, it helps blood circulation and stimulates metabolism. The purpose of the this study was to estimate the anti-inflammatory effects of the AT extract. METHODS: Human vascular endothelial cells were pre-treated with 100 μg/mL AT extract for 30 minutes and subsequently co-treated with TNF-α (10 ng/mL) and AT extract (100 μg/mL) for 1, 4, and 6 hours. After treatment, the cells were lysed and used for quantitative reverse transcription PCR, Western blot analysis, and monocyte adhesion assay. RESULTS: We examined the effect of the AT extract on inflammatory gene expression in TNF-α-induced human umbilical vein endothelial cells (HUVECs). The extract reduced the expression levels of mRNA and protein of intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in TNF-α-stimulated HUVECs. It also inhibited the TNF-α-induced phosphorylation of the NF-κB p65 subunit and degradation of IκBα. Furthermore, the AT extract prevented the increased adhesion capacity of monocyte to TNF-α-stimulated vascular endothelial cells by reducing ICAM-1 and VCAM-1 expression. CONCLUSIONS: The AT extract has preventive and anti-inflammatory effect against vascular disease and has potential for supporting prevention against the early process of atherosclerosis.
Allium* ; Ascorbic Acid ; Atherosclerosis ; Blood Circulation ; Blotting, Western ; Calcium ; Carotenoids ; Chive* ; Endothelial Cells* ; Functional Food ; Gene Expression ; Human Umbilical Vein Endothelial Cells ; Humans* ; Inflammation* ; Intercellular Adhesion Molecule-1 ; Iron ; Metabolism ; Monocytes ; Necrosis* ; NF-kappa B ; Phosphorus ; Phosphorylation ; Polymerase Chain Reaction ; Reverse Transcription ; RNA, Messenger ; Vascular Cell Adhesion Molecule-1 ; Vascular Diseases ; Vitamin A

PURPOSE: The aim of this study was to develop a substantive theory on self-management conducted by the adolescents with chronic kidney disease from their lived experience. METHODS: Data was collected through in-depth interviews from May to December in 2015 with thirteen adolescents with chronic kidney disease. The data collected were analyzed on the basis of Strauss and Corbin's grounded theory. RESULTS: The core of the category found in this study was “overcoming the unstable sense of self-control and integrating disease experience into their life”. The causal conditions triggering the central phenomenon were “restriction in daily life” and “manifestation and aggravation of symptom”. The central phenomenon in the experience of self-management within the adolescents with chronic kidney disease was “unstable sense of self control”. The intervening condition for unstable self control were “micro system support” and “motivational resources”. This study found that the adolescents with chronic kidney disease followed a series of strategies when they faced the central phenomenon, including; passive coping, reappraisal of illness, active coping, compliance with treatment, controlling physical activity, and adjusting school life. With these strategic approaches, the adolescents with chronic kidney disease could maintain their active lifestyles and achieve their health behaviors. The process of self-management by these adolescents passed through four phases; limited experience caused by diseases, effort for normalization, reorganizing their daily lives, and integration with daily lives and self-management. CONCLUSION: This Study explored the process and experience of self-management of adolescents with chronic kidney disease. These findings can be used for basis for developing substantive theory and nursing intervention strategy for adolescents with chronic kidney diseases.
Adolescent* ; Compliance ; Grounded Theory ; Health Behavior ; Humans ; Life Style ; Motor Activity ; Nursing ; Renal Insufficiency, Chronic* ; Self Care* ; Self-Control

Purpose: This study was conducted to develop a monitoring tool to manage unregistered mentally ill patients at community mental health centers (M-MUMI). Methods: The Delphi method was used in this study. The participants of this study were 27 psychiatric experts. In the first Delphi round, content analysis was conducted. In the second Delphi round, Kendall’s W rank and weight rank were used. The third Delphi round was analyzed based on the content validity ratio (CVR). Results: The finally developed M-MUMI consisted of 2 domains, 7 categories, and 22 items. Assessment of the present status consisted of 4 basic elements affecting daily life, 5 psychological statuses, 2 elements related to the utilization of social service, and 3 causes for the refusal of registration. The registration strategy of the individual cases consisted of 2 human resources to help registration, 2 additional social services for registration, and 4 individual needs to induce registration. Conclusion It is important to manage unregistered mentally ill patients at the community mental health centers. We hope that the developed M-MUMI will help to monitor unregistered mentally ill patients how to maintain mental health in the community.

BACKGROUND/OBJECTIVES: The purpose of this study was to examine the effects of knowledge about coronavirus disease 2019 (COVID-19), attitude, subjective norm, and perceived behavioral control on behavioral intentions to practice COVID-19 preventive behaviors using the theory of planned behavior (TPB). SUBJECTS/METHODS: A total of 519 restaurant customers' responses was collected in this study through an online self-administered questionnaire. Descriptive statistical analysis was performed on socio-demographic factors. One-way analysis of variance and t-test were conducted to determine differences in the constructs from the TPB according to age and sex.The hypotheses were tested using structural equation modeling (SEM). RESULTS: SEM revealed the positive effect of knowledge about COVID-19 on attitude, subjective norm, and perceived behavioral control to prevent the spread of COVID-19 in restaurants. Attitude, subjective norm, behavior intention, and knowledge positively affected COVID-19 preventive behavior intentions in restaurants. CONCLUSIONS The results of this study confirmed that the TPB is helpful in elucidating the determinants of consumers' intention to practice COVID-19 preventive behavior in restaurants. These findings can help policy makers and professionals provide material for further public health interventions and inform them about awareness-raising, guidelines, and health education programs.

OBJECTIVES: The objective of this study was to develop evidence- and consensus-based clinical safety usage guidelines for sedative hypnotics using the Delphi technique. METHODS: A group of 15 sleep experts from Korean Academy of Sleep Medicine were chosen for this study comprising a three-round web-based Delphi survey. The first round survey was composed of 39 questions to identify problems with sedative hypnotics usage in Korean clinical practice and the result roughly outlined what should be included in the guidelines. The second round survey was composed of 21 questions to collect specific opinions of experts on clinically important issues in prescribing sedative hypnotics, and its result provided the basis for the guidelines. A third round survey aimed to evaluate the reliability and validity of the established guidelines. RESULTS: In the third round, all 17 items showed a median of 4 or more, with an average of 4.12 and a standard deviation of 0.32. Thus we present safety usage guidelines with 13 propositions for prescription, maintenance, and withdrawal of sedative hypnotics. CONCLUSION The safety usage guidelines on sedative hypnotics developed from this study could lead to safe and effective prescription of hypnotics in clinical practice, especially for the non-experts in sleep medicine. Furthermore, the guidelines will help to improve the quality of insomnia treatment by contributing to the establishment of a safe regime for sedative hypnotics without excessive use of drugs.

In addition to cognitive and functional decline, various behavioral and psychological symptoms in dementia (BPSD) are manifested in the patients with Alzheimer's dementia (AD). Some of BPSD, especially psychosis, agitation, and aggression could be challenges to caregivers and clinicians. Atypical antipsychotic drugs (risperidone, olanzapine, quetiapine, and aripiprazole) are widely prescribed to manage complicated neuropsychiatric symptoms associated with AD. It is known that atypical antipsychotics (AAP) have modest and significant beneficial effects in the short term treatment of BPSD. However their safety of AAP has been concerned with potentially increased adverse events. This article reviewed the treatment outcomes and adverse effects of AAP when managing BPSD in the patients with AD. The effects of risperidone and aripiprazole are obvious on psychosis and aggression, but with small effect size. AAP could exacerbate cognitive decline, and it could increase the rate of cerebrovascular accidents and mortality rate in the patients with AD.
Aggression ; Alzheimer Disease ; Antipsychotic Agents* ; Behavioral Symptoms ; Caregivers ; Dementia* ; Dihydroergotamine ; Humans ; Mortality ; Psychotic Disorders ; Risperidone ; Stroke ; Aripiprazole ; Quetiapine Fumarate

The present study was carried out to investigate the effect of treatment with tryptophan and/or reserpine on the raphe of medulla oblongata and mid brain of the rats (180~200 g body weight). the animal were injected i.p. with reserpine (5 mg/kg) for 3 days and tryptophan (15 mg/kg) for 20 days. The results by immunohistochemical methods were as follows: 1. Serotonin-immunoreactive neurons in the raphe of medulla oblongata and mid brain decrease in reserpine treated group compared to all the other group. 2. Serotonin-immunoreactive neurons in the raphe of medulla oblongata and mid brain were increased in tryptophan -reserpine treated group compared to the reserpine treated group but not the tryptophan treated group. 3. Serotonin-immunoreactive neurons in the raphe of medulla oblongata and mid brain were inceased in tryptophan treated group compared to all the other group. The experiments indicated that serotonin immunoreactive neurons in medulla oblongata and mid brain increased due to the activation of tryptophan and decreased by suppressing activation of tryptophan through reserpine.
Animals ; Brain ; Medulla Oblongata* ; Mesencephalon* ; Neurons ; Raphe Nuclei* ; Rats* ; Reserpine* ; Serotonin ; Tryptophan*

These experiments were performed to investigate the effect of saline, stress, imipramine, stress -imipramine and/or stress -tryptophan on serotonin immunoreactivity in raphe nucleus of the rats (200 ~220 g, body weight). The animals were injected i.p. with imipramine (15 mg/kg) and tryptophan (15 mg/kg) after electric shocks for 20 days. The result by immunohistochemical methods were as follows; 1. Serotonin -immunoreactive neurons in the raphe nucleus of midbrain were significantly increased in stress treated group compared to saline treated group. 2. Serotonin -immunoreactive neurons in the raphe nucleus of midbrain were decreased in imipramine treated group compared all the other group. 3. Serotonin -immunoreactive neurons in the raphe nucleus of midbrain were significantly decreased in stress -imipramine treated group compared to stress alone treated group but were significantly increased in stress -imipramine treated group compared to imipramine treated group. 4. Serotonin -immunoreactive neurons in the raphe nucleus of midbrain were significantly increased in stress -tryptophan treated group compared to stress alone and saline treated group. These experiments indicated that serotonin immunoreactive neurons in raphe nucleus of midbrain were increased due to the activation of stress and decreased by suppresing activation of stress through imipramine treatment.
Animals ; Imipramine* ; Mesencephalon ; Neurons ; Raphe Nuclei* ; Rats* ; Serotonin ; Shock ; Tryptophan*

Glutamate is an amino acid neurotransmitter capable of producing widespread receptor-mediated neuronal excitation. In this experiment, we examined the effect of saline, monosodium glutamate (MSG), phenylalanine and MSG-phenylalanine treatment on TH immunoreactivity in area postrema (AP) of medulla oblangata. An immunocytochemical method was used to visualize catecholaminergic neurons in the AP. Damage of TH neurons in the AP of adult Sprague-Dawley rats was induced by injection of MSG (4 mg/g bw) and was decreased by administration of MSG following phenylalanine treatment (15 mg/g bw). We conclude that phenylalanine protect from the neuroexcitotoxic effect of systemic glutamate.
Adult ; Animals ; Area Postrema* ; Glutamic Acid ; Humans ; Neurons ; Neurotransmitter Agents ; Phenylalanine* ; Rats* ; Rats, Sprague-Dawley ; Sodium Glutamate*