Objective:To explore the influence of trimetazidine (TMZ)combined traditional routine drugs on progno-sis of patients with cardiac syndrome X.Methods:A total of 80 patients with cardiac syndrome X were randomly and equally divided into routine treatment group and TMZ group (received TMZ 20mg,three times/d based on routine medication).Both groups were treated for 12 weeks.Patients of two groups received treadmill exercise test and car-diac function examination before and after treatment,and the results were statistically compared.Results:Com-pared with routine treatment group after treatment,there were significant rise in total exercise time [(7.90±1.45) min vs.(9.35±1.70)min]and the time ST segment depressed 1mm [(5.30±1.43)min vs.(6.78±2.00)min], and significant reduction in ST segment depression extent [(0.89±0.30)mm vs.(0.61±0.20)mm],P <0.05 all;for cardiac function,there were significant rise in stroke volume [(67.99±11.77)ml vs.(74.05±7.58)ml]and left ventricular ejection fraction [(50.13±11.05)% vs.(56.02±9.52)%]in TMZ group,P <0.01 all.Conclusion:TMZ can significantly improve prognosis of patients with cardiac syndrome X.

Objective To investigate the effect of the expression of miRNA-106b-5p on the prognosis of non-small cell lung cancer (NSCLC) patients who received targeted therapy. Methods A total of 273 NSCLC patients who underwent targeted therapy from January 2012 to October 2013 in Dalian University Affiliated Xinhua Hospital were included. Fasting venous blood samples of all the hospitalized patients within 24 hours were collected, real time fluorescence quantitative polymerase chain reaction was used to measure the expression of miRNA-106b-5p, and their survival status were followed up. Kaplan-Meier method and log-rank test were used for survival analysis. Cox regression model was used to make multiple-factor analysis. Results There were 112 males and 161 females among 273 patients. The age was (61 ±12) years old. There were 40 patients having family history of cancer, 70 patients having smoking history. According to TNM stage, 77 patients were classified into stageⅠ, 39 patients were classified into stage Ⅱ, 107 patients were classified into stage Ⅲ and 50 patients were classified into stage Ⅳ. The relative expression level of miRNA-106b-5p was 1.72±0.67. Until October 2018, 27 out of 273 NSCLC patients lost follow-up. Of 246 follow-up patients, 185 patients (75.2％) died. The results of single factor survival analysis showed that family history of cancer (HR= 1.16, 95％ CI 1.07-1.31), smoking history (HR= 2.17, 95％ CI 2.08-3.26), advanced differentiation degree (HR=1.63, 95％CI 1.43-2.19), higher TNM stage (HR= 2.09, 95％CI 1.75-2.17), and high expression of miRNA-106b-5p (HR=2.37, 95％CI 1.63-3.63) were associated with the poor prognosis of NSCLC patients treated with targeted therapy. Multivariable Cox regression analysis showed that family history of cancer (HR= 1.15, 95％CI 1.09-1.27), smoking history (HR= 2.11, 95％CI 2.08-2.82), higher differentiation degree (HR= 1.42, 95％CI 1.31-1.89), higher TNM stage (HR= 2.07, 95％ CI 1.83-1.95), higher miRNA-106b-5p expression (HR=2.21, 95％CI 1.81-3.25) were the independent risk factors affecting the prognosis of NSCLC patients treated with targeted therapy. Conclusion The high expression of miRNA-106b-5p is associated with the increased risk of death among NSCLC patients treated with targeted therapy.

Objective:To investigate the effects of oxygen therapy on patients with acute myocardial infarction (AMI) and without hypoxia ,who were treated with emergency percutaneous coronary intervention (PCI) .Methods:This study was a sin‐gle‐center ,prospective and randomized controlled study .A total of 143 patients with AMI and without hypoxia ,who were un‐dergoing emergency PCI were divided into oxygen group and control group .The patients in oxygen group inhaled oxygen at a flow rate of 5 L/min via nasal catheter for 24 hours ,the patients in control group inhaled air .Before and after PCI ,the patients in each group received standardized drug treatment (including anti‐thrombotic and anti‐ischemic drugs ,statins and angiotensin‐converting enzyme inhibitors) in Coronary Care Unit (CCU) .The situation of AMI and PCI were observed in the two groups . The clinical data including hospitalization time ,Global Registry of Acute Coronary Events (GRACE) score ,levels of cardiac troponin I(CTnI) ,myocardial‐specific isoenzyme of creatine kinase (CK‐MB) and N‐terminal pro‐B‐type natriuretic peptide (NT‐ProBNP) ,as well as the occurrence rates of cardiac arrhythmias ,cardiogenic shock and death were recorded and ana‐lyzed .Results:There were significant differences (all P<0 .05) between oxygen group and control group in peak concentra‐tions of serum CTnI[33 .40 (22 .10 ,75 .43) ng/mL vs .23 .70 (14 .83 ,45 .45) ng/mL] ,CK‐MB [(252 .70 ± 132 .20)U /L vs .(189 .66 ± 97 .05) U /L] and NT‐ProBNP [810(535 ,1390) pg/mL vs .406(240 ,846)pg/mL] as well as arrhythmia oc‐currence (13 vs .9 cases) .Bute there was no difference in cardiogenic shock ,death and hospitalization time between the two groups(all P>0 .05) .Conclusions:Oxygen therapy may have no benefit and even cause potential myocardial injury for AMI pa‐tients without hypoxia in the process of emergency PCI treatment .

OBJECTIVES: Shelter hospital was an alternative way to provide large-scale medical isolation and treatment for people with mild coronavirus disease 2019 (COVID-19). Due to various reasons, patients admitted to the large shelter hospital was reported high level of psychological distress, so did the healthcare workers. This study aims to introduce a comprehensive and multifaceted psychosocial crisis intervention model. METHODS: The psychosocial crisis intervention model was provided to 200 patients and 240 healthcare workers in Wuhan Wuchang shelter hospital. Patient volunteers and organized peer support, client-centered culturally sensitive supportive care, timely delivery of scientific information about COVID-19 and its complications, mental health knowledge acquisition of non-psychiatric healthcare workers, group activities, counseling and education, virtualization of psychological intervention, consultation and liaison were exhibited respectively in the model. Pre-service survey was done in 38 patients and 49 healthcare workers using the Generalized Anxiety Disorder 7-item (GAD-7) scale, the Patient Health Questionnaire 2-item (PHQ-2) scale, and the Primary Care PTSD screen for the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (PC-PTSD-5). Forty-eight healthcare workers gave feedback after the intervention. RESULTS: The psychosocial crisis intervention model was successfully implemented by 10 mental health professionals and was well-accepted by both patients and healthcare workers in the shelter hospital. In pre-service survey, 15.8% of 38 patients were with anxiety, 55.3% were with stress, and 15.8% were with depression; 16.3% of 49 healthcare workers were with anxiety, 26.5% were with stress, and 22.4% were with depression. In post-service survey, 62.5% of 48 healthcare workers thought it was very practical, 37.5% thought more practical; 37.5% of them thought it was very helpful to relief anxiety and insomnia, and 27.1% thought much helpful; 37.5% of them thought it was very helpful to recognize patients with anxiety and insomnia, and 29.2% thought much helpful; 35.4% of them thought it was very helpful to deal with patients' anxiety and insomnia, and 37.5% thought much helpful. CONCLUSIONS Psychological crisis intervention is feasible, acceptable, and associated with positive outcomes. Future tastings of this model in larger population and different settings are warranted.
Humans ; COVID-19 ; Sleep Initiation and Maintenance Disorders ; Crisis Intervention ; Psychosocial Intervention ; SARS-CoV-2 ; Mental Health ; Depression/epidemiology* ; Health Personnel/psychology* ; Anxiety/etiology*