Objective To observe the efficacy and safety of small dose of estradiol valerate combination of oyster shell calcium chewable tablets treatment of postmenopausal osteoperosis. Methods Thirty-two patients with postmenopausal osteoporosis with oral estradiol valerate 1 mg/d, ovseter shell calcium chewable tablets 150 mg, three times one day, month after serving 15 days added medroxyprogesterone acetate 4 mg/d, at least were observed the course of six months. Results After treatment, bone density of L1-4 and left femur was increased significantly (P<0.05). Twenty-seven cases (84.4%) with six months treatment felt the pain in back and joints improved or disappeared, they could take care of themselves and take part in normal social activities. Four cases of patients within 3 months hod some irregular vaginal bleeding, and service improved after adding modroxyprogesterone acetate, 3 cases of patients with a mild to moderate expansion of mammary gland, one patient appeared leucorrhea increased, but soon turned for better. Conclusions Small dose of estradiol valerate combination of ovseter shell calcium chewable tablets treatment of postmenopausal osteoporosis has the effect of releasing pain, increasing bone density, preventing bone loss, evident result and fewer untoward reaction.

Objective To compare the biomechanical differences between injectable calcium sulfate hemihydrate to fill the bone graft fixed and a simple fixed tibial plateau fractures.Methods Create a rabbit osteoporosis tibial plateau collapse fracture model,filled with calcium sulfate bone graft and Kirschner wire fixation on a regular basis based on general observation,the general X-ray,bone mineral density ( BMD ) analysis,non-decalcified biopsy,mechanical loading experiment.Results Ordinary X-ray observations suggested that the fracture zone filled with calcium sulfate gradually degraded and absorbed by new bone tissue replacement.The 1,2,3,4,6,8,12 weeks after the filling of the bone cement treatment group rabbit calcium sulfate bone cement sample of the BMD of the fracture,the axial load carrying capacity was significantly higher than the blank control group,the difference was statistically significant ( P ＜ 0.01 ).Conclusion Osteoporosis rabbit tibial plateau fracture filling calcium sulfate bone cement early can increase bone density,improve the axial load carrying capacity.