OBJECTIVE:To analyze the characteristics and rules of pediatric adverse drug reaction (ADR) in our hospital, and provide reference for clinical safe drug use. METHODS:Retrospective study was adopted to statistically analyze the ADR re-ports in our hospital from Mar. 2012 to Jun. 2016. RESULTS:In the 176 ADR reports,102 were male(57.95%)and 74 were fe-male (42.05%);children younger than 6 years old had the highest incidence of ADR (81.26%);intravenous administration in-duced 153 cases(86.93%),the top one was antibiotics,which involving 20 antibiotics,totally 106 cases(60.23%);skin and its appendages damage were the main manifestations, totally 127 cases (50.60%). CONCLUSIONS:Pediatric ADR monitoring should be strengthened,dinical rational drug use should be promoted by cooperation in many ways to reduce and prevent the incid-erle of pediatric ADR.

Chimeric antigen receptor-transduced-T (CAR-T) cells shows strong cytotoxicity to the tumor with specific antigen by CTL effects and cytokines releasing without MHC-restriction.As multiple clinical trials from cancer centers around the West countries reported recent years,anti-CD19-CAR T cells can not only induce complete remission of B-cell malignancies resistant,but also eliminate the minimal residual disease (MRD) at the molecular level.It is believed that the obstacles from bench to clinic will be cleared and CAR will become one of the main cancer therapies with breakthroughs in comprehensive treatment of tumors.

[Objective]This paper will pitch-in TCM psychosomatic theory(from Huangdi Neijing),exploring the disorders of depression with the metabolic syndrome and pathogenesis of traditional Chinese medicine,so as to provide effective ideas for the treatment of depression with metabolic syndrome.[Methods]:Through expansion on traditional chinese medicine's basic understanding of depression with metabolic syndrome,utilizing basic TCM viscera-state theory, from the causes of this disease,key factors,pathogenesis transformation three aspects to discuss the pathogenesis of the disease. [Results]By discussing the heart,liver,spleen function of zang-fu organs and their mutual relations in the role and impact of the disease development process, this paper thinks of the nature of disease as asthenia in origin and asthenia in superficiality,which locates in spleen,has association with heart and liver, phlegm, qi and blood stasis is the disease of pathological product of pathological factors to promote the development of the disease.Kidney would be involved in it with long course of disease.The therapy could focus on tonifying spleen,nourishing heart and soothing liver,with methods of promoting the circulation of qi,removing blood stasis and reducing phlegm,meanwhile looking out to protect kidney.[Conclusion]Disorder of depression and pathogenesis of TCM of metabolic syndrome,to guide the clinical treatment of the disease and the theory of traditional Chinese medicine development has practical significance.

The present paper reviewed the recent researches on the toxicity and health effect of phthalate in the following four aspects: animal toxicology, population epidemiology, people exposure, and safety standard, moreover, some critical problems which should be studied as soon as possible were proposed.

Objective: To investigate the epidemiological characteristics of rubella in Wuxi City, Jiangsu Province from 2015 to 2023, so as to provide the basis for rubella prevention and control. Methods: Data of rubella surveillance cases and laboratory tests were collected through the Chinese Measles Surveillance Information Report Management System. The temporal, regional and demographic distribution of confirmed rubella cases were analyzed using the descriptive epidemiological method. Results: A total of 2 167 rubella surveillance cases were reported in Wuxi City from 2015 to 2023, including 154 confirmed rubella cases, with an average annual reported incidence of 0.25/105. All the confirmed cases were laboratory-confirmed, and the positive rate of laboratory testing was 7.11%. The main clinical symptoms were rash (96.75%) and fever (86.36%). The incidence of rubella peaked in 2015 and 2019, with sporadic cases in other years. Rubella incidence exhibited a distinct seasonal pattern, and the prevalent months were from February to May. Xishan District and Huishan District had the higher reported incidences, at 0.44/105 and 0.42/105, respectively. There were 101 male confirmed rubella cases and 53 female cases, with a male-to-female ratio of 1.91∶1. The incidence was higher in males than in females (0.32/105 vs. 0.18/105, P<0.05). The majority of cases were aged 19 to <46 years, with 112 cases accounting for 72.73%. There were 43 workers (27.92%) and 27 housekeepers and unemployed individuals (17.53%). The rubella containing vaccine immunization rate among the confirmed rubella cases was 12.99%, which was lower than the 36.20% among the cases excluding measles and rubella (P<0.05). The majority of the individuals aged 19 years and above had unknown immunization histories. Conclusions The reported incidence of rubella in Wuxi City remained low from 2015 to 2023. The disease was prevalent in winter and spring, and the cases mainly distributed in Xishan District and Huishan District. Individuals aged 19 to <46 years, males and workers were key populations for prevention and control.

The test concludes the existing prominent problems and main damages on medical morality recently in China,and it also discusses the necessity and feasible ways to reinforce the medical moral construction from the two aspects of theory and practice under social market economical condition.

Suturing is the key to the success of corneal transplant surgery.By analyzing the suturing-process of corneal,a model for suturing was established.A suturing theorietical trajectery was proposed without considering the viso-elasticity of comeal.Then,a suturing simulation was done with the ANSYS software,the manipulating trajectory was planned for corneal soft-tissue with viso-elasticity,correspondingly,and the position and posture of needle in suturing were obtained.The study can be used for suturing manipulation in cornea suture surgical.

Objective To explore the relationship among HBV DNA load, HBeAg/Anti-HBe and ALT in patients with chronic hepatitis B infection. Methods HBV markers in 134 patients with chronic HBV infection were detected by ELISA,and patients were divided into group Ⅰ (HBeAg +/Anti-HBe-,43 patients) ,group Ⅱ (HBeAg-/Anti-HBe + ,69 patients)and group Ⅲ (HBeAg-/Anti-Hbe-,22 patients)according to the results of presence of HBeAg/Anti-HBe. HBV DNA load and ALT were tested respectively by fluorescence quantitative polymerase chain reaction technology and successive monitor reaction. Results Both the positive rate and the HBV DNA load quantification in group Ⅰ were higher than in group Ⅱ and Ⅲ (P＜0.01). Abnormality rate of ALT in HBV DNA positive patients was higher than the patients with HBV DNA negitive(P＜0.01). There was no relationship between HBV DNA load and ALT in HBV DNA positive patients. Conclusion There was a certain corelation among HBV DNA load, HBeAg/Anti-HBe and ALT,but the active degree of HBV replication could not to be assessed by HBeAg/Anti-HBe or ALT alone. It was necessary for the padient with chronic HBV infection to examine them together.

The cell-impedance substrate sensor,which is mainly used to detect the shapes and function ofcells and other micro.organism.is a novel tool based on the technique of BIOMEMS to study the cellular physiologyand clinical Dharmasology.It has drawn attention from both domestic and international scholars as well as compa nies in recent years for its advantages such as innovative design and long-term non-invasive monitoring.This paperintroduces the interfacial model of cell-sensor in detail and gives a sketch of the recent international researchprogress.Then the novel interdigitated array,which was designed in our group recently,is introduced.The fore ground of development is discussed in the end.

A de-noising method for electrocardiogram (ECG) based on ensemble empirical mode decomposition (EEMD) and wavelet threshold de-noising theory is proposed in our school. We decomposed noised ECG signals with the proposed method using the EEMD and calculated a series of intrinsic mode functions (IMFs). Then we selected IMFs and reconstructed them to realize the de-noising for ECG. The processed ECG signals were filtered again with wavelet transform using improved threshold function. In the experiments, MIT-BIH ECG database was used for evaluating the performance of the proposed method, contrasting with de-noising method based on EEMD and wavelet transform with improved threshold function alone in parameters of signal to noise ratio (SNR) and mean square error (MSE). The results showed that the ECG waveforms de-noised with the proposed method were smooth and the amplitudes of ECG features did not attenuate. In conclusion, the method discussed in this paper can realize the ECG denoising and meanwhile keep the characteristics of original ECG signal.
Algorithms ; Electrocardiography ; Humans ; Signal Processing, Computer-Assisted ; Wavelet Analysis