1.Study on The Effects of Chronic Renal Failure on Hearing and Its Mechanism
Journal of Zhejiang Chinese Medical University 2006;0(02):-
[Objective]To observe the effects of chronic renal failure (CRF)on hearing and investigate its mechanism.[Methods] Twenty-nine male wistar rats were randomly divided into four groups:Ⅰthe normal rats as control for 12 days (n=6); Ⅱrats given adenine(ig) for 12 days (n=8); Ⅲthe normal rats as control for 24 days (n=6);Ⅳ rats given adenine(ig) for 24 days(n=9). The rat model of CRF was produced by being perfused of adenine [300mg/kg]for 12d and 24d. Brain-stem auditory evoked potential(BAEP) was utilized to evaluate the auditory function and renal tissue morphology was observed; Serum sampling was used to determine the content of Cr, BuN. The expression of NOSⅡin the cochlear was measured by immunohistochemical technique.[Results] After adenine given for 12d or 24d, the Cr and BuN were in significant higher level than that in control group. The BAEP thresholds were gradually higher than that in control group, the BAEP delitescence prolonged. Light microscopic observation of renal tissue showed that the degree of fibrosis was gradually higher. Data of immune histochemistry about the cochlear tissue showed that the expressions of NOSⅡ were feebly positive in the cochlear vassal texture, inner-outer hairy cell and helical-ganglion cell, and following functional damage of the kidney, their expressions reinforced gradually, amongst which strongest expression was vassal texture, the next helical-ganglion cell, the last inner-outer hairy cell.[Conclusion]CRF can result in deafness. It is likely concerned with toxic effects of the metabolizable substance, the metabolizable dysfunction of the electrolyte, shortage of trace elements, etc. One of the important mechanisms of the effects of CRF on hearing is the toxic damage of NO to cochlea.
2.DEPRESSIVE AND/OR ANXIETY DISORDER IN PATIENTS WITH AWARENESS DURING GENERAL ANESTHESIA
Modern Hospital 2009;9(7):15-17
Objective To reveal the prevalence of depressive and/or anxiety symptom and disorder in patients with awareness during general anesthesia.Methods 10 patients which had the awareness during general anesthesia were selected into AR group (awareness with recall during general anesthesia group).Face-to-face interviews were used in data collection together with the self-completed HAD scale for depressive and/or anxiety symptom screening.Subjects getting a HAD score of 9 and above were further assessed for depressive and/or anxiety disorders with HAMA scales and HAMD scales.Results The difference of common general state of patients, such as age, weigh and the time during operation were all insignificant between two groups (p>0.05).The rate of patients received general anesthesia only in AR group was higher than that in control group(p<0.05).The prevalence of depressive symptom, the prevalence of depressive or anxiety symptom and the prevalence of depressive and anxiety symptom in AR group were higher than that in control group(p<0.05).The prevalence of depressive disorder, the prevalence of depressive or anxiety disorder and the prevalence of depressive and anxiety disorder in AR group were higher than that in control group too(p<0.05).Conclusion There was high prevalence of depressive and/or anxiety symptom and disorder in patients with recall-awareness during general anesthesia.
3.Correlations between Self-Esteem and Life Satisfaction in Elementary School Students
Chinese Mental Health Journal 2002;0(11):-
Objective:To explore the correlations between self-esteem and life satisfaction in elementary school students. Methods:494 elementary school students were measured with CSES (Children's Self-Esteem Scale) and BMSLSS (Brief Multidimensional Students' Life Satisfaction Scale). Results: (1) There were significant gender and grade differences on self-esteem in elementary school students. Girls got higher scores(Means were 3.8?0.8?3.8?0.9?3.9?0.8)than boys on achievements, discipline and social morality-help(Means were 3.5?0.9?3.2?0.8?3.6?0.9,F=17.2?47.0?16.6, P
4.Life Satisfaction between Urban and Rural Middle School Students
Chinese Mental Health Journal 2002;0(10):-
Objective: To compare the differences between urban and rural middle school students on life satisfaction. Methods: 1152 urban and rural middle school students were measured by Multidimensional Students'Life Satisfaction Scale ( MSLSS - CV) . Results: ( 1 ) The urban students had higher scores than their rural counterparts on all the satisfaction dimensions ( mean value differences = 0. 2 - 0. 4. For example, the family satisfaction of urban and rural students were 4. 6?1. 0, 4. 2?1.0 respectively, mean value difference =0. 4; the serf satisfaction of urban and rural students were 4. 6?0. 7 , 4. 4?0. 7 respectively, mean value difference = 0. 2 ) . ( 2 ) The mean values rank (from high to low) of the five dimensions on the satisfaction was family, self, friend, school and living environment in urban students. The mean values rank (from high to low) of the five dimensions on the satisfaction was self, family, friend, school and living environment in rural students. (3 ) The difference between city and countryside had higher explained percentage than popularity on all the satisfaction dimensions. The percents were as follows: 5% , 10% , 4% , 6% , 17% , 11%. Conclusion: There were significant differences on life satisfaction between urban and rural middle school students.
5.Research on medical data mining and its applications.
Journal of Biomedical Engineering 2014;31(5):1182-1186
With the development of computer technology, medical data has developed from traditional paper pattern into electronic mode, which could effectively promote the medical development. This paper at first presents the status and characteristics of medical data mining. Then, it discusses the critical method of medical data mining in classification, clustering and prediction, respectively. The paper focuses on the application and assessment of five algorithms which are designed for medical data mining, including decision tree, cluster analysis, association rule, intelligent algorithm and the mix algorithm. Finally, this paper outlooks the data mining application in medical domain.
Algorithms
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Cluster Analysis
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Data Mining
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Decision Trees
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Medical Informatics
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Software
6.Prevention and treatment of vagus reflex after percutaneous coronary intervention
Chinese Journal of Practical Internal Medicine 2001;0(07):-
Vasovagal reflex is one of complications from cardiac intervention.The major causes of vasovagal reflex postprocedure are commonly believed to be associated with mental stress,pain,low blood volume,visceral dilation,local hematoma and cardiac function.The incidence of vasovagal reflex may be effectively reduced with standard intervention training,strictly selected indications for PCI,adequate fluid replacement after procedure,anesthetic lidocaine to reduce pain,improved manual compression for vascular hemostasis and elimination of risk factors.
7.Retrospective Study of Clinical Factors Correlated to Eclampsia
Journal of Shanghai Jiaotong University(Medical Science) 2000;20(6):518-520
Objective To evaluate the clinical factors correlated to eclampsia.MethodsPregnant women with pregnancy- induced hypertension syndrome (PIH) in 5 years were retrospectiv-ely studied. The relations between eclampsia and prenatal care, PIH degree and the dose of magnesiumsulphate used were evaluated, as well as the eclarnptic aural symptoms and their occurring time. Re-sults The incidence of eclampsia in pregnant women was 0.56 %, and 8.33 % in the PIH cases. Eclamp-sia was significantly correlated to antenatal care. The incidence of eclempsia in cases with moderate andsevere PIH were higher than that with wild PIH. Less than 15g magnesium sulphate (MgSO4) used perday in moderate and severe PIH cases had an eclampsia incidence rate as high as 20.00 %. And the inci-dence in the mild PIH cases was comparatively lower, but still as high as 6.19%. Aural symptoms al-ways appeared prior to eclampsia. Almost all eclampsia cases had the aura within 24h prior to the attack.ConclusionProper and effective antenatal care was of great importance in the prevention of the eclamp-sia. In moderate and severe PIH the eclampsia incidence was higher, but could be decreased by the pro-per use and sufficient amount of MgSO4. It should be emphasized that mild PIH could still develop intoeclampsia. All eclampsia cases had aura which must be paid attention to in PIH cases.
8.New discoveries about the role of SREBPs in the pathogenesis and targeted therapy of gynecological tumors
Clinical Medicine of China 2017;33(5):471-474
Objective Sterol regulatory element-binding proteins(SREBPs) are a family of nuclear transcription factors that regulate lipid metabolism in eukaryotic cells.They are over expressedin many malignant tumors,and closely related to tumor initiation and progression.We briefly summarize the research advancement of SREBPs in gynecological tumors.
9.Stressing the Idea of Excellent Course and Strengthening Diagnostics Curriculum Development
Chinese Journal of Medical Education Research 2006;0(07):-
Diagnostics is a highly practical course.According to the training model,we set up the goals of curriculum development,optimized and updated the teaching contents,attached importance to teaching materials development,reformed the teaching methods and strengthened faculty training.It started with each teaching step of diagnostics,the teaching quality has been remarkably improved.
10.Exploration on PBL mode in diagnosis pathological teaching of postgraduate
Chinese Journal of Medical Education Research 2003;0(04):-
Using PBL Teaching Mode in the clinical diagnosis pathological teaching of Postgraduate during clinical practice is not only good for students to arouse the interests of learning,consolidate their pathological knowledge and enhance pathological diagnosis consciousness, but also helps improve their general capabilities of clinical pathological diagnosis thinking,analyzing and solving problems. It does lay a solid foundation for the postgraduates to become clinical pathologists.