[Objective]To observe the effects of chronic renal failure (CRF)on hearing and investigate its mechanism.[Methods] Twenty-nine male wistar rats were randomly divided into four groups:Ⅰthe normal rats as control for 12 days (n=6); Ⅱrats given adenine(ig) for 12 days (n=8); Ⅲthe normal rats as control for 24 days (n=6);Ⅳ rats given adenine(ig) for 24 days(n=9). The rat model of CRF was produced by being perfused of adenine [300mg/kg]for 12d and 24d. Brain-stem auditory evoked potential(BAEP) was utilized to evaluate the auditory function and renal tissue morphology was observed; Serum sampling was used to determine the content of Cr, BuN. The expression of NOSⅡin the cochlear was measured by immunohistochemical technique.[Results] After adenine given for 12d or 24d, the Cr and BuN were in significant higher level than that in control group. The BAEP thresholds were gradually higher than that in control group, the BAEP delitescence prolonged. Light microscopic observation of renal tissue showed that the degree of fibrosis was gradually higher. Data of immune histochemistry about the cochlear tissue showed that the expressions of NOSⅡ were feebly positive in the cochlear vassal texture, inner-outer hairy cell and helical-ganglion cell, and following functional damage of the kidney, their expressions reinforced gradually, amongst which strongest expression was vassal texture, the next helical-ganglion cell, the last inner-outer hairy cell.[Conclusion]CRF can result in deafness. It is likely concerned with toxic effects of the metabolizable substance, the metabolizable dysfunction of the electrolyte, shortage of trace elements, etc. One of the important mechanisms of the effects of CRF on hearing is the toxic damage of NO to cochlea.

Objective To reveal the prevalence of depressive and/or anxiety symptom and disorder in patients with awareness during general anesthesia.Methods 10 patients which had the awareness during general anesthesia were selected into AR group (awareness with recall during general anesthesia group).Face-to-face interviews were used in data collection together with the self-completed HAD scale for depressive and/or anxiety symptom screening.Subjects getting a HAD score of 9 and above were further assessed for depressive and/or anxiety disorders with HAMA scales and HAMD scales.Results The difference of common general state of patients, such as age, weigh and the time during operation were all insignificant between two groups (p>0.05).The rate of patients received general anesthesia only in AR group was higher than that in control group(p<0.05).The prevalence of depressive symptom, the prevalence of depressive or anxiety symptom and the prevalence of depressive and anxiety symptom in AR group were higher than that in control group(p<0.05).The prevalence of depressive disorder, the prevalence of depressive or anxiety disorder and the prevalence of depressive and anxiety disorder in AR group were higher than that in control group too(p<0.05).Conclusion There was high prevalence of depressive and/or anxiety symptom and disorder in patients with recall-awareness during general anesthesia.

Objective:To explore the correlations between self-esteem and life satisfaction in elementary school students. Methods:494 elementary school students were measured with CSES (Children's Self-Esteem Scale) and BMSLSS (Brief Multidimensional Students' Life Satisfaction Scale). Results: (1) There were significant gender and grade differences on self-esteem in elementary school students. Girls got higher scores(Means were 3.8?0.8?3.8?0.9?3.9?0.8)than boys on achievements, discipline and social morality-help(Means were 3.5?0.9?3.2?0.8?3.6?0.9,F=17.2?47.0?16.6, P

Objective: To compare the differences between urban and rural middle school students on life satisfaction. Methods: 1152 urban and rural middle school students were measured by Multidimensional Students'Life Satisfaction Scale ( MSLSS - CV) . Results: ( 1 ) The urban students had higher scores than their rural counterparts on all the satisfaction dimensions ( mean value differences = 0. 2 - 0. 4. For example, the family satisfaction of urban and rural students were 4. 6?1. 0, 4. 2?1.0 respectively, mean value difference =0. 4; the serf satisfaction of urban and rural students were 4. 6?0. 7 , 4. 4?0. 7 respectively, mean value difference = 0. 2 ) . ( 2 ) The mean values rank (from high to low) of the five dimensions on the satisfaction was family, self, friend, school and living environment in urban students. The mean values rank (from high to low) of the five dimensions on the satisfaction was self, family, friend, school and living environment in rural students. (3 ) The difference between city and countryside had higher explained percentage than popularity on all the satisfaction dimensions. The percents were as follows: 5% , 10% , 4% , 6% , 17% , 11%. Conclusion: There were significant differences on life satisfaction between urban and rural middle school students.

Translational medicine is an emerging idea in current medical research area. Typically, for the purpose of bridging the gap between basic and clinical research, it not only emphasizes the urgency and necessity to break the traditional working formats, including single subject centered research team and limited cooperation among different scientific groups, but also highlights a more close and frequent interaction between basic scientist and clinician. In order to reach this goal, the theory and method of systems biology should be employed. This paper mainly focused on a central issue that how to carry out an investigation on early clinical diagnosis of xenobiotic-induced intrauterine growth retardation (IUGR) by using research concept of translational medicine and method of systems biology. Briefly, a hypothesis of common mechanism of IUGR was first proposed and subsequent validation was performed via integrating--omics (e.g. genomics, proteomics, cytomics, metabonomics/metabolomics) and molecular biology techniques. Metabonomics was further utilized to explore IUGR biomarker and establish preliminary forecasting model by bioinformatics and computational biology, which is available for early diagnosis of IUGR and make a complement to current evaluation criteria.

Objective To detect the alteration of circulating CD34 + cell level in patients with the In'st-ever nonlacunar stroke and to investigate the prognostic value of CD34 +cell level. Methods 1he level of the circulating CD34+ cells were examined using flow eytometry in 119 patients with nonlacunar infarction. 1he patients were divided into group A (higher than average) and group B (lower than average) according to the detected values, The National Institutes of Health Stroke Scale (NIHSS) scores on admission and the modified Rankin Scale (mRS) scores at 3 months after the onset in the two groups wre compared. Results The level of CD34 + cells in group A was significantly higher than that in group B (0. 048 ± 0. 001 versus 0. 032 ± 0. 002, P < 0. 05 ), however, there was no significantly difference in NIHSS sores between the two groups. One week after admission, the increased level of CD34 + cells in group A was significantly higher than that in group B (0. 001 ±0. 003 versus - 0. 005 ± 0. 000, P < 0. 05 ). Three months after the onset of symptoms, the average mRS score in group A was significantly superior to that in group B (2. 98 ± 1.14 versus 3.25 ± 1.39, P <0. 05). 1he level of circulating CD34 + cells at the initial onset of symptom was negatively correlated with the mRS score at 3 months after stroke (r = -0. 48, P <0. 05). Conclusions The higher level of circulating CD34+ cells had better prognosis in patients with cerebral infarction. The level of circulating CD34+ ceils may be used as a prognostic indicator in patients with cerebral infarction.

Adult ; Female ; Histiocytosis, Sinus ; Humans ; Nasal Cavity ; pathology ; Paranasal Sinuses ; pathology

Comprehensive geriatric assessment (CGA) conducts comprehensive assessment of many aspects of health and well-being of an older patient including medical,functional,nutritional,psychiatric and behavioral issues and needs as well as family and social support.CGA is typically conducted by a multidisciplinary team led by a geriatrician.Based on the CGA findings,appropriate recommendations are provided to the patient and family.This paper introduces the CGA concept and its content,targeted population,and implementation methods.It will also describe clinical studies focusing on the effectiveness and utility of CGA.

Objective To acknowledge the psychological authority status under the foundation of autho0rization management,in order to analyze the effectiveness of authorization management.Methods 364 clinical nurses were investigated with Psychological Empowerment Scale and the results were performed statistic analysis through descriptive statistical method and variance analysis.Results The average score of clinical nurses was(3.22±0.70),which was at the moderate point.The four dimensional scores listed in descending order were self efficient,career significance,autonomy and job influence.Clinical nurses of different ages,different ranking,different working period,different marriage status had statistical outstanding variance.But nurses of different education background showed no significant difference in score of each dimension.Conclusions The nursing management shall not only focus on the authorization management itself,but also on the psychological authority status of clinical nurses.Through an efficacious incentive,we can enhance the psychological recognition and experience on authorization and activate the working motivation,maximize the working initiative and thus promote the innovation and expansion of nursing work.

ObjectiveTo investigate the psychological and behavioral intervention on the rehabilitation of patients with chronic fatigue syndrome.MethodsIn this prospective,single blind study,71 outpatients diagnosed with chronic fatigue syndrome according to the criteria of the U.S.Centers for Disease Control were recruited and were divided randomly into two groups by coin method,one group for systematic psychological and behavioral intervention (31 cases) and the other group (the control group) for antidepressant drug treatment only (40 cases).Chronic Fatigue Assessment Scale ( FAI ) was used to estimate patients＇ clinical efficacy.ResultsEach factor score of FAI in psychological and behavioral intervention group was significantly improved after treatment ( S (3.20± 1.72) ;SS(4.01 ± 1.32) ; PC(4.95 ± 1.82) ;RTR / S(6.02 ± 1.59) ) (P＜0.01).Three factor scores of FAI in the control group were improved(P ＜ 0.01 ),but one factor score of this group was not significantly improved (S ( 5.39 ± 1.33 ) ) (P ＞ 0.05 ),Total improvement was not clear (P ＞ 0.05 ).Research group of significant efficiency,the total effective rate was significantly higher than that of control group.Compliance results showed,psychological behavior intervention group follow-up without falling off,the control group had 8 cases to fall off.Psychological and behavior intervention treatment efficacy and disease course,＜ 12 months in patients with good effect.ConclusionBoth of psychological and behavioral interventions and antidepressant medication are effective therapies for patients with chronic fatigue syndrome,the former is slightly better.