Ankle sprains are orthopedic clinical common disease, accounting for joint ligament sprain of the first place. If treatment is not timely or appropriate, the joint pain and instability maybe develop, and even bone arthritis maybe develop. The mechanism of injury of ankle joint, anatomical basis has been fully study at present, and the diagnostic problem is very clear. Along with the development of science and technology, biological modeling and three-dimensional finite element, three-dimensional motion capture system,digital technology study, electromyographic signal study were used for the basic research of sprain of ankle. Biomechanical and kinematic study of ankle sprain has received adequate attention, combined with the mechanism research of ankle sprain,and to explore the the biomechanics and kinematics research progress of the sprain of ankle joint.
Ankle Injuries ; physiopathology ; Ankle Joint ; physiopathology ; Biomechanical Phenomena ; Finite Element Analysis ; Humans ; Sprains and Strains ; physiopathology

Hemorrhagic Disorders ; genetics ; Humans

Antineoplastic Agents ; therapeutic use ; Humans ; Neoplasms ; drug therapy ; Precision Medicine ; methods

Anemia, Hemolytic ; etiology ; Humans ; Hypercholesterolemia ; blood ; complications ; Intestinal Diseases ; blood ; complications ; Lipid Metabolism, Inborn Errors ; blood ; complications ; Phytosterols ; adverse effects ; blood ; Thrombocytopenia ; etiology

Cardiomyopathies ; chemically induced ; Chlorine Compounds ; poisoning ; Female ; Humans ; Middle Aged ; Oxides ; poisoning

Objective To investigate health related behavior and its affecting factors among occupational populations living in Xicheng District of Beijing so as to provide good evidence for health management services.Methods A total of 33 936 permanent residents aged 15 years or above living in Xicheng District of Beijing were randomly selected with stratified multi-stage cluster random sampling method from November 2008 to March 2009,among whom 12 980 incumbency residents aged 18-60 years old were analyzed.A self-designed questionnaire was used,and height,body weight and blood pressure were measured.Multivariate non-conditional logistic regression was used for data analysis.Results The responding rate was 92.3％ (33 936/36 761).The rate of lacking physical exercise,overweight,current cigarette smoking,alcohol drinking,over-intake of salt and obesity was 62.2％ (8 074/12 980),31.6％ (4 104/12 980),25.0％ (3 249/12 980),23.5％ (3 047/12 980),17.9％ (2 324/12 980)and 8.7％(1 125/12 980),respectively.In logistic regression,the risk factors of insufficient physical exercises were current cigarette smoking and over-intake of salt,while its protective factors were male,age and higher education level (all P＜0.05).The risk factors of overweight and obesity were male,age,alcohol consumption and over-intake of salt,while its protective factor was higher education level (P＜0.05).The risk factors of current cigarette smoking were male,age,alcohol drinking,lack of physical exercises and over-intake of salt,while its protective factor was higher education level (P＜0.05).The risk factors of alcohol consumption were male,age,overweight and obesity,current cigarette smoking and over-intake of salt (all P＜0.05).The risk factors of over-intake of salt were overweight and obesity,current cigarette smoking,alcohol intake and lack of physical exercises,while its protective factor was higher education level (P＜0.05).Conclusion Our investigation suggests that the occupational population should be offered with health education and behavioral intervention.

BACKGROUND:Insulin-like growth factor-1 can promote mitosis of fibroblasts as wel as periodontal cellgrowth, differentiation and synthesis of extracelular matrix.
OBJECTIVE: To observe the effects of chitosan/colagen composite scaffold carrying insulin-like growth factor-1 on proliferation of human periodontal ligament cels.
METHODS: The human periodontal ligament cels were seeded on chitosan/colagen composite scaffold carrying insulin-like growth factor-1 and ordinary colagen scaffold. The release of recombinant human transforming growth factor-β1 was detected at 1, 24 hours and 1 week after culture; celladhesion and proliferation were detected at days 1, 7 and 28.
RESULTS AND CONCLUSION:The release rate of recombinant human transforming growth factor-β1 in the composite scaffold was significantly lower than that in the ordinary colagen scaffold at 1, 24 hours and 1 week after cellseeding (P < 0.01). The celladhesion and proliferation showed no difference between two groups at day 1 after cellseeding, but became significantly higher in the composite scaffold than that in the ordinary colagen scaffold at days 7 and 28 (P < 0.01). These findings indicate that chitosan/colagen composite scaffold carrying insulin-like growth factor-1 can significantly promote the proliferation of the human periodontal ligament cels.

Objective To evaluate and compare the clinical effects of forward and reverse anterior cruciate ligament (ACL) reconstruction through the arthroscopy. Methods From April 2008 to August 2009,97 cases with simple ACL injures were treated with eight strands of hamstring tendons in way of two-bundle and four-tunnel reconstruction. The patients were randomly divided into two groups according to the number of hospital admissions: odd numbers (A group, 47 cases) were treated with forward double-bundle reconstruction and even (B group,50 cases) were treated with reverse. The grafts were fixed with a suspension technique by mini-plates and mini-buttons. Mean follow-up exceeded one year. The function of knee joint were assessed by the IKDC, Lysholm and Tegner rating scale. Results Mean follow-up was 13.71 months.At the last follow-up, 2 patients in A group had a 10°extension deformity and 5 had a less than 15° flexion limitation. All patients in B group showed normal knee extension, and 4 had a 5° flexion limitation. According to Lachman test, there were one case with one plus positive and one with two plus positive in A group,and one with two plus in B. KT-1000 examination (30° flexion and 30 N) showed the side to side mean difference of anterior knee laxity was (1.04±1.11) mm in A group and (0.86±1.12)mm in B. According to objective IKDC evaluation, the results were graded as normal or nearly normal in 46 patients in A group and 48in B. There were no statistical differences in the IKDC, Lysholm, and Teguer scores between two groups.Conclusion Forward or reverse ACL double-bundle reconstruction with eight strands of hamstring tendons can both restore knee stability, and there is no significant deviation between the two techniques.

Radical trachelectomy (RT) is known as a developing sign of the surgical treatment of cervical cancer in the 21st century.RT brings hope for the patients with early cervical cancer who eager to retain their fertilities.The extent of surgery include RT and pelvic lymphadenectomy.The major methods of radical trachelectomy include abdominal (RAT) and vaginal (RVT) approaches.The efficacy and feasibility of RT is similar with standard treatment,which has great application value in clinical.

In recent years,many breast cancer therapeutic vaccines have been entered several clinical trials,which bring a new promising treatment for breast cancer.These trials reveal the advantages and characteristics of tumor-associated antigens,and put forward the questions waiting to be solved.