Objective To investigate the effect of autologous serum therapy in the treatment of three cases of exposure keratitis after general anesthesia.Method Autologous serum therapy was used to treat 3 cases of exposure keratitis,the curative effects assessed by the patients’complaints and observation of the ocular symptoms.Result All the patients reported eliminations of exposure keratitis and symptomatic relief.Conclusions The autologous serum therapy is effective for the treatment of exposure keratitis.The nursing strategies of keeping cornea moist,preventing infections,performing mental nursing and storing serum properly are critical for the enhanced curative effect.

Objective To investigate the effect of different frequencies of pudendal electrical nerve stimulation on female stress urinary incontinence.Methods 60 SUI female patients from Shanghai Research Institute of Acupuncture and Meridian affiliated Yue Yang Hospital were enrolled in a three-times-per-week treatment group (30 paients) and a twice-per-week treatment group (30 patients).Both groups were treated by pudendal nerve electrical stimulation for twelve times.The change of therapeutic effect,symptoms index were observed in both groups before and after the treatment.Results ① Comparison of clinical efficacy:The therapeutic rate of three-times-per-week treatment group was 63.3％ (19/30),the total effective rate was 90.0％ (27/30); the therapeutic rate of twice-per-week treatment group was 36.7％ (11/30),the total effective rate was 76.7％ (23/30).The therapeutic rate showed significant differences between the two groups (x2=4.267,P＜ 0.05); The total effective rate showed no differences between the two groups (x2 =l.920,P＞0.05).② Comparison of clinical symptom score and life quality score:the post-treatment clinical symptom scores of the both groups improved significantly compared with the pre-treatment (tthee-times-prt-week=7.972,ttwice-per-week=9.520,both P＜0.01).Clinical symptom score of three-times-per-week treatment group improved better than twice-per-week treatment group (P＜0.01).Conclusion Three-times-per-week of pudendal nerve electrical stimulation has a better effect on treating female SUI patients.

Radical trachelectomy (RT) is known as a developing sign of the surgical treatment of cervical cancer in the 21st century.RT brings hope for the patients with early cervical cancer who eager to retain their fertilities.The extent of surgery include RT and pelvic lymphadenectomy.The major methods of radical trachelectomy include abdominal (RAT) and vaginal (RVT) approaches.The efficacy and feasibility of RT is similar with standard treatment,which has great application value in clinical.

In recent years,many breast cancer therapeutic vaccines have been entered several clinical trials,which bring a new promising treatment for breast cancer.These trials reveal the advantages and characteristics of tumor-associated antigens,and put forward the questions waiting to be solved.

Objective To investigate the clinical effect of laparoscopic operation and laparotomy in the treat-ment of uterine fibroids.Methods A retrospective analysis of uterine fibroids and requests to retain the clinical data of 380 cases of uterine of patients,according to treatment methods,they were divided into laparoscopic myomectomy group (group A)and cesarean section uterine fibroids removed surgery group (B group),there were 190 cases,two groups of patients,surgery,clinical effect were analyzed.Results In group A,operation time,postoperative exhaust time,postoperative ambulation time,postoperative VAS score,duration of hospitalization,injection of analgesics appli-cation proportion were (96 ±35)min,(24 ±8.5)h,(12 ±4)h,(2.0 ±1.5),(4.0 ±1.2)d,17.8%,patients in the group B respectively (98 ±28)min,(40 ±12)h,(20 ±8)h,(6.0 ±1.3),(8 ±2)d,84.6% there was a significant differences between the two groups (t=-2.558,33.96,45.810,50.571,34.120,χ2 =169.89,all P<0.05);group A and group B,the amount of bleeding were (186 ±78)mL and (175 ±85)mL,with no significant difference between the two groups (t=1.911,P>0.05);group A,the complication rate was 7.34%,lower than the 12.6%in the group B,there was significant difference between the two groups (χ2 =3.923,P<0.05).Conclusion Laparoscopic myo-mectomy in treatment of uterine fibroids,good effect,less trauma,quicker recovery,shorter hospitalization time of patients,should be further popularized in clinic.

Objective To evaluate the similarity of dissolution profiles of self-produced and original drug cefuroxime axetil tab-lets.Methods Based on the dissolution detection method in the Chinese Pharmacopoeia,the dissolution behaviors of the self-pro-duced preparation and original drug were investigated in pure water,0.1 mol/L hydrochloric acid,0.05 mol/L hydrochloric acid, pH4.5 and pH6.8 medium and the rotation speed of 50,25,75 r/mim.The stripping curves were evaluated by the f2 factor method. Results In the rotation speed of 50 r/min,the f2 factors in different mediums were 57.65,79.17,73.56,66.83 and 62.33 respec-tively;the medium was 0.1 mol/L hydrochloric acid with the rotation speed of 25,75 r/min,the f2 factors were 65.35 and 78.48 re-spectively.Conclusion The stripping curves of self-produced preparation and original drug are similar under various conditions.

Objective To evaluate the effect of management by objective implementation in neurology department nurse training.Methods Divided the nursing students into the experimental group and the control group according to their student ID,there were 100cases in each group.Routine training was used in the control group,while the training based-on management by objective was used in the experimental group.Compared the intervention effects between the two groups.Results The scores of theory,skills and the comprehensive performance in the experimental group was significant higher than that of in the control group respectively,P＜0.01.The excellent rate of theory and skills in the experimental group was 57.95％ (2 434/4 200) and 49.74％ (1 691/4 200),which was significant higher than those of in the control group [28.62％ (1 202/3 400) and 21.91％ (745/3 400)],P＜0.01.The intervention measures had increased the theoretical scores 21.011 times,OR=21.011,95％CI 9.752-45.269,increased the skills scores 14.625 times,OR=14.625,95％ CI7.032-30.416,increased the comprehensive performance 23.993 times,OR=23.993,95％CI1.085-51.934.Conclusion The implementation of management by objective on nurse training can improve the trainee's theory and professional knowledge,the nursing skill can be improved also.So the comprehensive training effect is higher than before.

Objective To explore the diffusion-weighted magnetic resonance imaging (DWI) and apparent dispersion coefficient(ADC) value in cerebral infarction diagnosis and judgment of cerebral infarction outcome and staging of the value.Methods According to different stages,26 patients were divided into 3 phases,phase Ⅰ (6 ～72 h) had 11 cases,phase Ⅱ (4 ～ 10 d) had 12 cases,phase Ⅲ (10 d later) had 9 cases,of which 3 cases were reviewed,3 cases were recurrence of cerebral infarction.Each patient's MRI included T1 weighted imaging,T2 weighted imaging,DWI and ADC sequence scan image reconstruction,the ADC map obtained one regions of interest (ROI),and the mean ADC value of ROI were calculated,the average ADC value of the corresponding contralateral area were also calculated by the same method,and then the mean relative ADC value were calculated.Results DWI image of all cases showed high signal,11 cases showed high signal and 1 case showed low signal in phase Ⅱ.In phase Ⅲ,1 case showed normal signal and 1 case showed high signal,2 cases showed mixed signal,1 case were reduced,and the rest were all low signal.Compared with the contralateral corresponding region,the average ADC values were reduced in phase Ⅰ.The infarction average ADC values were 0.434 × 10 3mm2/s,0.653 × 10-3mm2/s,1.600 × 10-3mm2/s in phase Ⅰ,Ⅱ,Ⅲ respectively,and the average ADC values of contralateral corresponding region were 0.938 × 10-3 mm2/s,0.814 × 10-3 mm2/s,0.757 × 10-3 mm2/s respectively; the mean relative ADC values were (51.5 ±16.8)％,(79.2 ±30.0)％,(210.9 ±45.1)％ in phase Ⅰ,Ⅱ,Ⅲ respectively (P ＜ 0.05).Conclusion ADC value of cerebral lesions area and relative ADC value of the variation in time provides an objective basis for the diagnosis of DWI,contributes to timely and accurately determine the age of cerebral lesions and pathophysiology of the changes.

Objective To explore the relationship between life events,efficacy of self learning and learning burnout of Left-behind middle school Students.Methods 526 left-behind middle school students and 860 non -left-behind students were tested by means of scales of life events,academic self-efficacy and learning burnout.Results The degree of interpersonal relationship,learning pressure,health adaptation,life events,self-efficacy of learning ability,learning behaviors,and learning,sense of alienation between teacher and students,physiological depletion,and learning burnout of left-behind middle school students were lower than non left-behind students,and were statistically significant.The interpersonal relationship(r=0.270,P＜0.001),learning pressure(r=0.289,P＜ 0.001),being punished(r=0.242,P＜0.001),health adaptation(r=0.301,P＜0.001) and others (r=0.322,P＜ 0.001) were positively related to learning burnout.Self-efficacy of learning ability(r=-0.334,P＜0.01) and learning behaviors(r=-0.157,P＜0.001) were significantly and negatively related.Interpersonal relationship (r=-0.092,P＜0.05),learning pressure (r=-0.123,P＜0.01),being punished (r=-0.178,P＜0.001) and others (r=-0.254,P＜ 0.001) were negatively related to self-efficacy of learning ability.Being punished (r=-0.109,P＜ 0.05)and others(r=-0.209,P＜0.001) were significantly and negatively related to self-efficacy of learning behaviors.Self-efficacy,health adaptation,learning pressure,self-efficacy of learning behavior and others all entered the regression equation.Path analysis showed that there were five paths that have significant influences on learning burnout.Conclusion The levels of response to emergency of life events and enhance the academic self-efficacy of leftbehind students can be improved to reduce and prevent learning burnout.

Objective To understand the incidence and related risk factors of healthcare-associated infection(HAI)in neu-rological patients with cerebrovascular diseases.Methods The occurrence and risk factors of HAI in patients with cerebro-vascular diseases in a hospital between Jan and December 2013 were investigated and analyzed.Results Of 3 573 investiga-ted patients,214 had HAI,the incidence of HAI was 5.99%;the main infection site was respiratory tract (54.67%),fol-lowed by urinary tract (25.23%).Univariate analysis revealed that age,length of hospitalization,disturbance of conscious-ness,chronic obstructive pulmonary disease,diabetes mellitus,invasive procedures,application of antacids,and antimicro-bial prophylaxis were all related to the occurrence of HAI (P<0.05).Multivariate logistic regression analysis revealed that disturbance of consciousness,old age,invasive procedures,chronic obstructive pulmonary disease,and diabetes mellitus were independent risk factors for the occurrence of HAI (all P <0.05).Conclusion The incidence of HAI is high in hospitalized patients of the neurology department,there are multiple risk factors associated with HAI,it is necessary to take corresponding interventions for reducing the incidence of HAI.