Acupuncture Points ; Child, Preschool ; Dyspepsia ; therapy ; Female ; Fever ; therapy ; Humans ; Male ; Massage

Current bioprosthetic heart valves implanted with viable human cells can be categorized into two basic designs, tissue engineering heart valve and porcine aortic valve implanted with viable human cells. Tissue engineering heart valve is constructed by seeding a synthetic polyglycolic acid fiber based biodegradable scaffold with viable human autologous cells. The fibroblasts are first seeded on valve scaffold. When the fibroblasts reached confluence, endothelial cells are seeded onto the surface of leaflets and grown into a single monolayer. Porcine aortic valve implanted with viable human cells is generated by removing native cells from tissue and then repopulating the tissue with viable human autologous cells. The method of removing native cells from fresh porcine aortic valve comprises subjecting the valve tissue to a hypotonic/hypertonic treatment, then treating the valve tissue with an enzyme-based solution. Isolated cell lines are cultured and thereafter such a valve matrix is implanted with fibroblasts, followed by endothelial cells. Bioprosthetic heart valves implanted with viable human cells do not produce and adverse immune response by the recipient upon implant, and possesses the regenerative capabilities.

Objective:Cardiac index(CI) and mixed venous oxygen saturation SvO2 were studied in 85 patients undergoing coronary artery bypass grafting(CABG). Methods: Measurement of CI and SvO2 was carried out with a fiberoptic ballon-tip thermodilation pulmonary artery catheter. Fentanyl-based anesthesia was applied in all patients. Hemodynamic parame-ters were obtained prior to anesthesia induction as the baseline, after endotracheal intubation, after stemotomy, after weaning of cardiopulmonary bypass, at 6 and 24h after operation. Results: CI and SvO2 increased or was not changed at all time intervals, compared with the baselines. The changes of SvO2 correlated well with those of CI. Conclusion: The results suggest that continuous monitoring of SvO2 may be useful to predicting alteration in CI in patients undergoing CABG.

To explore the role of cytochrome C oxidase (CCO) in the pathogenesis of preeclampsiais, CCO activity was determined in 32 patients with preeclampsia and 26 normotension pregnancy women by the rate of cyanide-sensitive oxidation of reduced cytochrome c using ultraviolet spectrophotometry. The results showed that CCO activity was significantly lower in the preeclampsia group (0. 30±0. 39/min, n=32) than in the control group (0. 73±0. 54/min, n=26), P＜0. 01. The occurrence of IUGR in the preeclampsia group was significantly higher than in the control group (P＜0. 05). It was suggested that the decrease of activity of CCO might interfere with the function of electronic chains, result in the reduction of ATP production, leading to the mitochondria dysfunction and placental dysfunction in preeclampsia patients. Mitochondria dysfunction may be involved in the pathogenesis of preeclampsia.

With a view to patterns of local recurrence after breast conserving surgery, whole breast irradiation(WBI) after surgery is controversial and partial-breast irradiation(PBI) came up. Many clinical trials related with accelerated partial-breast irradiation using a variety of radiotherapeutic techniques such as interstitial brachytherapy (IBT), MammoSite Radiation Therapy System, intraoperative radiotherapy(IORT), threedimensional conformal radiotherapy(3-DCRT)and intensity modulated radiation therapy(IMRT) in selected patients have been carried out. Accelerated partial-breast irradiation that provides faster, more convenient treat-ment demonstrates local control rate and safety comparable to that of whole breast irradiation. Partial breast irradiation may be an alternative way to whole breast radiotherapy and will be one of the standard treatments in women with early breast cancer seeking breast conservation.

Pluripotent stem cells are type of cells that can differentiate into cells of ectoderm,mesoderm and endoderm layers.Cells isolated from developing embryos such as embryonic stem cells,embryonic germ cells,as well as cells derived from adult tissues and bone marrow and testis,have been proved to be pluripotent.Recent studies demonstrated that differentiated cells from adult could be reprogrammed to become pluripotent by genetic manipulation.The characteristics of pluripotent cells from different origins are summarized in this review,and the possible relationship between those populations is discussed.

The conventional treatment options for advanced gastric carcinoma patients remain unsatisfactory in terms of response rate and overall survival benefit. Targeted therapy plus systemic chemotherapy now becomes a new promising therapeutic option. In this review we profiled important trials of international multicenter phase Ⅲ clinical studies in patients with advanced gastric carcinoma, including ToCA trial, EXPAND trial, LOGIC trial, AVAGAST trial, REAL3 trial, and granite-1 trial. These trials warrant the role of molecular targeted therapy in patients with advanced gastric carcinoma.

Objective To investigate the value of methylprednisolone pulse therapy on the acute treatment of multiple sclerosis.Methods 46 cases of the acute phase of patients with multiple sclerosis treatment in the hospital's department of neurology were chosen,who were divided in accordance with the principle of randomized controlled study group and the control group,each group of 23 patients.The study group was given methylprednisolone in the treatment and control group were given dexamethasone treatment.The clinical efficacy and complications of the treatment of patients were compared.Results The study group markedly in 14 cases,effective 54 cases,the total effective rate was 82.6％ ;the control group,10 casesmarkedly effective in 4 cases,9 cases ineffective,the total effective rate was 60.9％ ; compared the two sets of data decline before treatment,there was a statistically significant difference (x2 =5.236,P ＜ 0.05).After the treatment,the two groups of patients with EDSS scores compared with EDSS scores of the study group was significantly lower than that of the control group,the difference was statistically significant(t =3.135,P ＜ 0.05).Conclusion In acute phase of patients with multiple sclerosis,methytprednisolone pulse therapy can reduce the incidence of complications,and reduce the patient's nervous system damage,which can improve the quality of life in patients.

Objective To investigate the clinical efficacy and mechanism of electrical pudendal nerve stimulation (EPNS) in treating female stress urinary incontinence.Methods Thirty-five female patients with stress urinary incontinence were enrolled from May 2006 to April 2008.The average age was (54.9±9.7) years,the duration of incontinence was (74.1 ±45.6) months,the maximum urethral closure pressure was (63.7± 15.9) cm H2O,functional urethral length was (2.34±0.72) cm and bladder neck mobility was (1.23±0.76) cm.Long acupuncture needles were deeply inserted into four sacral points,which were located by the two edges of the sacrum on a level with the fourth sacral foramina and bilaterally to the tip of the coccyx.The needles were electrified (continuous waves,a frequency of 2.5 Hz,an intensity of 45-55 mA and 60 min once) to stimulate the pudendal nerves.When EPNS was performed,perineal ultrasonographic B-mode movements of the pelvic floor muscles (PFM),M-mode curves indicating the PFM contractions,vaginal pressure (VP) and PFM electromyogram were recorded simultaneously.Results When EPNS was performed correctly,the patient felt strong PFM contractions.Simultaneous records showed:1)B-mode cranio-caudal PFM movements; 2) M-mode PFM movement curves (amplitude:about 1 mm,n=31 ; in the other four patients,the M-mode curves were not obvious) ; 3) a sawtooth curve of VP changes (2.61±1.29 cm H2O,n=34); 4) PFM myoelectric waves (amplitude:23.9±25.3 μV).If during the EPNS process the electric current was stopped or its intensity was reduced or the two lower needles were drawn back 1-2 cm,then the above ultrasonographic PFM movements and VP changes disappeared.In the 35 patients,the ICI-Q-SF score was 12.9±2.9 before treatment and decreased to 3.5±3.3 after 27.5± 11.9 sessions of treatment (P＜0.01).Twenty-five patients with ≥50％ symptom improvement at the end of treatment were followed up for 24-72 months (mean 50),and 19 cases had ≥ 50％ symptom improvement during the period of follow-up,including complete symptoms resolution in 10 cases.Conclusion EPNS can contract the PFMs and simulate PFM training to treat female stress incontinence.

Acute kidney injury is one of a number of conditions that affect kidney structure and function,which is a broad clinical syndrome encompassing various etiologies.There are general management principles that are common to all patients and these will be discussed here.Management of patients with acute kidney injury according to the stage and cause include hemodynamic monitoring,ensuring volume status,discontinuing all nephrotoxic agents,and nutritional support.