Acupuncture Points ; Child, Preschool ; Dyspepsia ; therapy ; Female ; Fever ; therapy ; Humans ; Male ; Massage

Targeted agents for small cell lung cancer (SCLC)include inhibitors of angiogenesis,tyro-sine kinase inhibitors and signal transduction pathway inhibitors.Bevacizumab,a class of antiangiogenic agent, tends to have no effects on patients.The tyrosine kinase inhibitor,for example sunitinib,may be used as a monotherapy.Signaling inhibitors including Amuvatinib and LDE225 are undergoing phaseⅠand Ⅱ trials.Pri-mary data show that SCLC is not sensitive to targeted therapy,needing more selection,so further studies are requested.

[Objective] To observe clinical therapeutic effect of combined acupuncture and acupoint thread implantation on insomnia. [Methods] The seventy two cases were randomly divided into a treatment group(37cases) and a control group(35cases).The treatment group were treated with acupuncture and acupoint thread implantation; The control group were treated with acupuncture alone. Acupuncture treatment was provided every other day,they were totally treated for 10 times;Acupoint thread implantation was provided one time every week,observe the clinicial therapeutic effect after 3 times of treatment. [Result] The effective rate on chloasma was 89.19%in the treatment group and 71.42%in the control group.The clinical effect in the treatment group was significant better than that in the control group(P<0.05). [Conclusion] Acupuncture combined with acupoint thread implantation shows a better therapeutic effect on insomnia.

Objective To investigate the relationship between neonatal health and TCM constitution types of early to mid-pregnancy expectant parents;To provide basis for the targeted interventions for couples of childbearing age before pregnancy-periconceptional TCM constitution. Methods Compiling scales for pregnant couple’ TCM constitution type assessment and postpartum visits to newborns, the research team got access to the information of neonatal physical problems, constitutions and changes of 675 babies’ father and mother who had established maternal manual from April, 2012 to March, 2013 at the Sanlin Community Health Center of Pudong District of Shanghai. Results Early to mid-pregnancy expectant parents mainly had peace constitution type. In detail, 55% of pregnant women had gentle constitution type, while others mainly had qi deficiency, yang deficiency and damp-heat constitution types;76% expectant fathers got peace constitution, while others mainly got damp-heat, yin deficiency and qi deficiency constitution types. Marital pregnancy physique did not change significantly. Compared with the peace constitution type, newborns, whose fathers got damp-heat constitution type, had higher risk of jaundice, and whose mothers got yin deficiency, the babies had higher risk of spits (P<0.05). The constitution types of expectant parents did not have obvious combined action on neonatal health. Conclusion There is a certain relationship between neonatal health and TCM constitution types of early to mid-pregnancy expectant parents. It is necessary to distinguish constitution types of prospective parents, and thus to take targeted health interventions.

Radiotherapy has become one of the most important treatments for cervical carcinoma. In recent years,because of the organ motion,anatomical changes and setup errors et cetera,the accurate external beam radiotherapy( EBRT)may regard to the difference between the actual dose delivery and the pre-treatment plan,which not only causes target less,but also brings additional doses to the organs at risk( OAR). By using of image guidance and individual modelling,adaptive radiotherapy( ART)can analyze the parameters of target position,volume and dose and adjust optimized plans for the follow-up treatment based on aforesaid feedbacks and enable the enhancement of the local control rate while reducing the incidence of the side reaction.

Objective To observe the therapeutic effects and toxicities of bone marrow-sparing intensity-modulated radiation therapy (BMS-IMRT) for postoperative cervical cancer.Methods From January 2011 to June 2012,totally 70 postoperative patients with cervical cancer were divided into BMS-IMRT group with 34 cases and IMRT group with 36 cases randomly.External whole pelvic intensitymodulated irradiation combined with chemotherapy was carried out for all patients.The planning target volume received a dose of 45 Gy/25 fractions in all patients.Delineation of the pelvis and limitation dose were carried out in BMS-IMRT group:the pelvis V30 ≤ 50％.All cases received chemotherapy with cisplatin (40 mg/m2) once a week concurrently with radiotherapy.Results Treatment was completed in 67 patients,as the other 3 patients stopped chemotherapy because of myelosuppression.There was no statistically significant differences between two groups for the 2-year local control survival(LCS)and overall survival(OS),alimentary tract toxicity and urinary toxicity.IMRT group had more serious hematologic toxicity than BMS-IMRT group,with statistically significant difference (x2 =14.355,P ＜ 0.05).Conclusions The postoperative cervical cancer patients with poor prognostic factors who undergo concurrent chemoradiotherapy,IMRT group has more serious hematologic toxicity than BMS-IMRT group.The short-term effect and other toxicities reaction are similar between two groups.

Cerebral small vessel disease refers to the diseases that affects intracranial small arteries,arterioles,precapillaries,and venules.The image-based types mainly include white matter lesion,lacunar infarction,and cerebral microbleeds.It is believed to be the independent risk factors of cognitive impairment or vascular dementia.The location,number and volume of the small vessel diseases may all influence the degree of cognitive impairment and manifestation.

BACKGROUND:The human telomerase reverse transcriptase (hTERT) is one of preferred growth factors for regulating proliferation and directional differentiation, has multiple biological effects, and laids the foundation for geneticaly engineered immortalized stem cel lines. OBJECTIVE: To investigate the effect ofhTERT gene-modified umbilical cord mesenchymal stem cel transplantation on acute kidney injury induced by ischemia and reperfusion in rats. METHODS:The human umbilical cord mesenchymal stem cels were cultured in vitro. Rat models of acute kidney injury induced by ischemia and reperfusion were established. Rat models were randomly divided into three groups. Rats in the control group were injected with 1 mL L-DMEM medium through caudal vein. Rats in the negative transfection group were injected with 1 mL umbilical cord mesenchymal stem cel suspension after empty virus transfection through caudal vein. Rats in the hTERT transfection group were injected with 1 mL umbilical cord mesenchymal stem cel suspension after PLXSN-hTERT transfection through caudal vein. RESULTS AND CONCLUSION:At 3 and 28 days after transplantation, hematoxylin-eosin staining showed renal tubular damage score in the hTERT transfection group < negative transfection group < control group (P < 0.05). At 28 days after transplantation, the number of CM-Dil-positive cels in the hTERT transfection group > negative transfection group > control group (P < 0.05). At 1, 3, 14, and 28 days, serum creatinine and urea nitrogen levels in the hTERT transfection group < negative transfection group < control group (P < 0.05). The results confirm that hTERT gene-modified umbilical cord mesenchymal stem cel transplantation has a significant repair effect on acute kidney injury in rats.

Ever since 1980’s, outcome-based learning (OBL) has been applied to the reform in education as a systematic method in the whole world. It’s based on the expected learning outcomes and emphasized on study from the aspect of students, and its target is to let the students transform what they have learnt into practice. Therefore, it’s widely rewarded in the undergraduate medical education. As a basic theoretical course in acupuncture-moxibustion and an essential component in traditional Chinese medicine, Meridians and Acupoints is a compulsory course for overseas students in studying traditional Chinese medicine. The authors induced OBL into the study of this course and correspondingly conducted exploratory reform in the education of evaluation, by taking practice as the expected outcome and reversely designing teaching and evaluation.

Objective:To explore the relation of mobile phone addiction to perceived social support and sub-jective well-being in college students. Methods:Totally 4000 college students were selected from 2 colleges,and they were assessed with the Mobile Phone Addiction Inventory (MPAI),Perceived Social Support Scale (PSSS) and subjective well-being scale (SWB). Results:The college students of mobile phone addiction were 1420 cases, accounting for 37. 9%. Except the dimension of negative emotion,the PSSS total scores and its factor scores,the SWB total scores and its factor scores were lower in the Mobile Phone Addiction (MPA)group than in the non-MPA group (Ps<0. 00 1 ). Regression analysis indicated significant negatively predictability of MPAI to subjective well-being and PSSS had significant positively predictability to SWB. The test of mediating effect found that PSSS and its 3 dimensions played a partly mediating role between MPAI and SWB,and the mediation effect account for the total effect 24. 89%,16. 1 1%,17. 33%,17. 78% respectively. Conclusion:There may be a close relation of mobile phone addiction to perceived social support and subjective well-being. Mobile phone addiction could directly affect subjective well-being and indirectly affect subjective well-being through perceived social support.