AIM: To investigate the growth inhibition effects of CDA-II on breast cancer cells. METHODS: The effects of CDA-II on growth curve and morphology of breast carcinoma cell lines MCF-7 and MDA-MB-231 were observed in vitro cultures. RESULTS: CDA-II reduced the growth speed and proliferation ability. CONCLUSION: CDA-II has remarkable effects on anti-cell-proliferation and shows good prospects of application in the treatment of patients with breast carcinoma.

Objective:To investigate the effect of rosuvastatin on carotid arterial intima-media thickness of elderly patients and its comparison with simvastatin.Method:126 patients hospitalized during January and August 2008 were randomly divided into a treatment group and a cotrolled group.All the patients were male and older than 70 years old,and their mean age was 78.9?8.8 years.63 patients accepted the rosovastatin therapy and 63 patients accepted the simvastatin therapy.Result:After 8-weeks'therapy,CIMT was reduced from 1.58?0.24mm before the treatment to 1.44?0.22mm after it.There was no difference between the two groups in decreasing CIMT.No adverse events related to the study medication were observed.Conclusion:The treatment with rsuvastatin can prevent the increase of carotid arteriosclerosis in eldlerly patients without any difference in decreasing CIMT,compared with simvastatin.

Objective To explore the influence of nursing intervention on patients with schizophrenia receiving repetitive transcranial magnetic stimulation (rTMS) treatment.Methods A total of 80 patients with schizophrenia receiving (rTMS) treatment were randomly divided into intervention group 40 cases and control group 40 cases by random digits table method.The control group was given routine care, and the intervention group was given routine nursing and nursing intervention.Before and after treatment, the curative effect was evaluated by the Positive And Negative Symptoms Scale, and the completion of the treatment between two groups was compared.Results The Positive Scale score, Negative Scale score, General Psychopathology Scale, total score in intervention group after treatment were lower than those in control group:(13.1±2.3) points vs.(16.7±2.1) points,(11.5±2.6) points vs.(15.3±2.3) points, (28.3±2.3) points vs.(30.9±2.2) points,(56.9±1.8) points vs.(67.4±1.7) points, and there were significant differences, t=2.398,2.401,2.452,2.191 ,P＜0.05.There was no significant difference in the rTMS completion, x2=5.541, P＜0.05.Conclusions Nursing intervention can effectively improve the patients with schizophrenia completion of rTMS treatment to improve mental symptoms, so as to improve the clinical curative effect, promote patients recovery of disease.

Objective:To determine the diagnostic performance of dynamic contrast-enhanced MRI (DCE-MRI) in patients with recurrent or residual prostate cancer after radical prostatectomy. Methods:Studies were systematically searched in the PubMed, EMBASE, Cochrane library, SCI, CBM, CNKI, VIP, WanFang, and other databases. Additional studies were manually searched using the references of the retrieved articles. The retrieved deadline time was June 6th, 2013. Studies were eligible for inclusion based on the inclusion and exclusion criteria, and the qualities of the studies were reviewed based on the QUADAS criteria. The Meta Disc 1.4 software was used for meta-analysis, and a summary receiver operating characteristic (SROC) curve was constructed. The patient-based pooled weighted estimates of the sensitivity, specificity, diagnostic odds radio, and 95%confidence interval were calculated. Results:Among the 118 eligible studies, 7 articles (12 studies) were included in the meta-analysis. The pooled weighted estimates of the sensitivity, specificity, and the area under the curve were 0.88 (95%confidence interval:0.84 and 0.91), 0.87 (95%confidence interval:0.81 and 0.92), and 0.939 1, respectively. The pooled diagnostic radio (dOR) was 50.4 (95%confidence interval:26.0 and 97.6) and Q*was 0.876 4. Conclusion:DCE-MRI has high sensitivity and specificity in the evaluation of locally recurrent or residual prostate cancer after radical prostatectomy, in which the diagnostic efficiency of DCE-MRI combined with magnetic resonance spectroscopy is much better.

Aim To explore the protective role of schisandrin B (SchB)against HK-2 damage induced by Cisplatin and the probable mechanism.Methods Cultivated HK-2 was interacted by Cisplatin and SchB with different concentrations.Invert microscope showed cellular form change and Flow Cyto Meter told apopto-sis.Combined with test result on the change of L-DH, MDA and LPO,probable protective effect of SchB on HK-2 was studied and analyzed.Result Cisplatin in-hibited cells′growth and induced apoptosis.20 μmol · L-1 SchB significantly reduced apoptosis of Cispla-tin-induced HK-2,and offered the best protection. SchB could reduce MDA,LPO,LDH significantly in-creased by cisplatin.Conclusion SchB can be an ef-fective inhibition agent of Cisplatin-induced renal tubu-lar epithelial cell apoptosis (HK-2 ).The mechanism can be the inhibition of Cisplatin-induced oxidative stress by antioxidant effect.

Objective: To summarize the efficacy of nape multiple acupuncture for treating vertebral artery type of cervical spondylosis. Methods: Patients with vertebral artery type of cervical spondylosis who visited from 2001 to 2004 were randomly divided into a control group of 50 cases receiving simple medication and an acupuncture plus medication group of 50 cases receiving medication plus nape multiples acupuncture. Results: Compared with the control group, the clinical cure rate was significantly increased in the acupuncture plus medication group (P＜0.05). Conclusion: Medication plus nape multiple acupuncture can obviously improve the therapeutic effect on vertebral artery type of cervical spondylosis.

Objective To investigate the role of vascular cell adhesion molecule 1 (VCAM 1) in pathogenesis of pregnancy induced hypertension (PIH) complicated by fetal growth restriction (FGR). Methods The placenta samples were collected from 30 pregnant women with PIH complicated by FGR, 28 FGR patients without PIH and 30 normal pregnant women. Immunohistochemical analysis was used to demonstrate the positive expression of VCAM 1 in placenta vascular endothelium and syncytiotrophoblast of these samples. Results In placentas of PIH complicated by FGR (80%),expression of VCAM 1 in the decidual vascular endothelium was significantly higher than those without PIH (25%) and normal placentas (15%)( P

Objective To study the relationship between matrix metalloproteinase-9 in syncytiotrophoblast and placenta pathological change of fetal growth restriction. Methods The placental samples were collected from 30 patients with FGR and 30 normal pregnant women who delivered in our hospital from January 2001 to September 2001. The tissue sections were dealt with HE stain and PAS stain and then observed by microscope to find the morphological change. 5 another samples from each group were observed by 500H model electron microscope. Immunohistochemical analysis was employed to demonstrate the positive expression of the MMP-9 in syncytiotrophoblast of FGR placenta. Results There are significantly pathological change in 22 placentas of FGR and abnormal rate is 73.33%. The count of stroma fibrosis and fibrinoid necrosis of villi(63.3%), villous vascular decrease and gore(70.0%), villous syncytial knots(43.3%), cytotrophoblasts increase(50.0%) were more significant in the placenta of FGR group than that of normal group(6.7%,10.0%,3.3%,13.3%)(P

Objective To determine that atorvastatin might have anti-inflammatory effects in acute coronary syndromes(ACS) with C-reactive protein(CRP) reduction.Methods Ninety-two patients with ACS were assigned to three groups: high dose atorvastatin group(31 cases),taking atorvastatin 40 mg daily.Standard dose atorvastatin group(31 cases),taking atorvastatin 10 mg daily,and control group(30 cases),only receiving conventional therapy.CRP levels,lipid profiles were measured at first and fifth day and 1 month later.Results The study suggested:(1)CRP levels significantly decreased from baseline to the fifth day and 1 month later in high dose atorvastatin group(P

Objective To investigate the expression of HLA DR on the platelet membrane and the activation of CD4 +T lymphocyte with idiopathic thrombocytopenic purpura (ITP) Methods By flow cytometry, HLA DR expressed on platelet membrane and IL 2 level produced by activated CD4 +T lymphocyte in 60 patients with ITP and 60 normal volunteers were measured Results The percentage of platelet expressing HLA DR (0 808?0 218)% measured in 60 patients with ITP by flow cytometry analysis was markedly higher than that in control subjects (0 025?0 019)% ( P