1.Security issues and corresponding measures in using Clinic Electronic Llinac
Chinese Medical Equipment Journal 2003;0(11):-
This paper briefly introduces some security issues in using Clinic Electronic Llinac and provides corresponding measures and suggestions,which give a reference for persons of the same occupation in security management and operation of Clinic Electronic Llinac.
2.Clinical Status of Antidepressant Treatment
Chinese Journal of Prevention and Control of Chronic Diseases 2006;0(02):-
Treatment of depression is divided into drug treatment and non-drug treatment. Drug therapy including tricyclic、 tetracyclic antidepressant category、Serotonin reuptake inhibitors (SSRI)、Serotonin receptor antagonist and re-absorption inhibitors (SARI)、norepinephrine and dopamine reuptake inhibitors (NDRI)、 serotonin and norepinephrine reuptake inhibitors (SNRI)、 norepinephrine and specific serotonergic antidepressants (NaSSA) and synergist to support treatment; Non-drugs treatments include psychotherapy, electric shock therapy、transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS)treatment.In clinical practice for a number of studies provide hope that patients with depression.
3.Factors Related with Final Test for Continued Learning of Rehabilitation
Chinese Journal of Rehabilitation Theory and Practice 2013;19(9):899-900
Objective To investigate the factors related with final test for continued learning of rehabilitation. Methods The records of 511 continued learning students for physical therapy were analysed with linear regression, with the results of theoretical and operating test as independent variable, while sex, age, titles, profession, education, works, levels of hospital and evaluations as independent variable. Results The results of both theoretical and operating test related with profession, education, works levels and evaluation. Conclusion The models estimate the results of continued learning for rehabilitation has been established.
4.The effective assessment of diabetes mellitus and nonalcoholic fatty liver disease treated by Exenatide
Chongqing Medicine 2015;(16):2228-2230
Objective To assess the effectiveness of Exenatide on non‐alcoholic fatty liver disease(NAFLD) with diabetes mellitus by evaluating fatty liver index(FLI) variation .Methods One hundred and two NAFLD patients with type 2 diabetes melli‐tus were enrolled and divided into two groups .One group were treated with Exenatide and another with Oral antidiabetic agents . The data of BMI ,blood fat ,HbA1c ,ALT ,AST ,GGT ,FLI and so on were collected at enrollment and the end point of 24 weeks treatment .The effectiveness of Exenatide were analysed by Kolmogorov‐Smirnov and Pearson correlation coefficient (r) analysis . Results The indicators of metabolic disorder ,the parameters of liver biochemistry and fatty liver disease (FLI) were significantly improved (P<0 .05) after 24 weeks treatment by Exenatide .While only BMI showed significant decrease after 24 weeks treatment with Oral antidiabetic agents(P<0 .05) .The rest of the parameters in oral antidiabetic agants group showed no significant differ‐ence (P>0 .05) .Conclusion Exenatide has a positive effect on non‐alcoholic fatty liver disease treatment who with type 2 diabetes mellitus ,especially for liver fat accumulation .
5.Advances in the association of metabolic syndrome with incidence and development of osteoarthritis
Chinese Journal of Orthopaedics 2016;36(4):248-256
Osteoarthritis (OA) is the most common form of arthritis, and is the major cause of pain and chronic disability worldwide, causing enormous social and economic burden.Once OA was considered as a 'wear-and-tear' condition and obesity is considered to be one of the most powerful predisposing factors of OA in the weight-bearing joints.However, studies have also linked obesity to OA in non-weightbearing areas, suggesting systemic effects exerted by metabolic factors other than simple local biomechanics perhaps play a role in the high prevalence of osteoarthritis in obese population.Recent studies have shown that systemic metabolic abnormalities, including obesity, diabetes, hypertension, lipid metabolism disorders, atherosclerosis and cardiovascular disease, play an important role in OA pathological process.Metabolic diseases promote the incidence and development of OA through a variety of ways, inducing causing low-grade systemic inflammation, increasing release of adipokines, anabolic cytokines and inflammatory mediators, leading to glucose and lipid metabolism disorders of chondrocytes, upregulating of cartilage extracellular matrix degrading enzymes, raising oxidative stress injury, increasing apoptosis of articular chondrocytes and reducing the cartilage and subchondral bone nutrition supply.These metabolic changes ultimately accelerate the damage of cartilage and promote the incidence and development of OA.Further research on OA and metabolic diseases, has the potential to provide new ideas and methods for the prevention and treatment of OA.
6.Cloning and high level expression of gene encoding human sCR1 binding domain in E.coli
Journal of Third Military Medical University 2003;0(15):-
Objective To clone and express the gene encoding the binding domain of human soluble complement receptor type 1 (sCR1). Methods sCR1-SCR15-18 cDNA was amplified using RT-PCR from human monocytes of peripheral blood and sequenced using vector pMD-18T. Recombinant pET32-sCR1-SCR15-18 was constructed using prokaryotic expression vector pET32 and transformed into bacterium BL21. IPTG was used to induce gene expression and the obtained expression product was identified by immunoblotting. Results The gene segment that specifically encodes sCR1 was synthesized, the sequence of which was consistent with that of sCR1-SCR15-18 cDNA as registered at GenBank. A prokaryotic expression recombinant pET32-sCR1-SCR15-18 was constructed. The amount of target protein accounted for 40% of the total bacterial proteins and inclusion bodies were present in the bacteria. Immunoblotting showed a single positive band at the site of 43?10~(3). Conclusion The gene encoding sCR1-SCR15-18 was cloned from human monocytes and efficiently expressed in E.coli.
7.Ca~(2+) signaling and pancreatitis
Chinese Pharmacological Bulletin 1987;0(03):-
To date, pancreatitis lacks of specific pharmacological therapy. Recently, it has been found that cytosolic Ca2+ overload causes pancreatitis. This article summarized the earliest events of Ca2+ transport in pancreatic acinar cell during pancreatitis and the influence of bile, alcohol, and hyperlipidaemia.Abnormal Ca2+ signal can be inhibited by caffeine. Based on these results, potential therapeutic targets are suggested.
8.Effects of bradykinin on the expression of interleukin-1? in C6 glioma cells
Chinese Pharmacological Bulletin 2003;0(09):-
Aim To investigate the effects of bradykinin on the expression of IL-1? in C6 glioma cells and provide an experimental basis for the mechanism of bradykinin opening the blood tumor barrier.Methods Semi-quantitive RT-PCR and radioimmunoassay were used to detect the expression of IL-1?mRNA in C6 glioma cells and the content of IL-1? in the culture media treated with bradykinin respectively.Results RT-PCR revealed that the expression of IL-1?mRNA was significantly elevated with bradykinin treated for 15min(P
9.Calcium/also a double-edged sword?
Chinese Pharmacological Bulletin 2003;0(11):-
Calcium supplement is needed for Chinese people.Calcium antagonists are also used in China.Authors suggest that calcium owns dual direction effects like a double-edged sword.Based on the knowledge of calcium metabolism,the adverse drugs reactions of excessive calcium supplement and the harmful effects of cellular calcium overload are introduced.Scientific and efficient application of calcium agents and calcium antagonists is expected.
10.Prevention and treatment of headache based on yun-qi theory
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(01):-
Headache is a common disease in clinical,abnormity of climate doubles risk of headache.We systematize the yun-qi theory about the disease in Suwen,at the same time,give some medical record,analyze the role of outside factors in the cause of headache.