1.Application of Hepatic Partial Resection for Hepatic Trauma:A Clinical Report of 36 Cases
Journal of Chinese Physician 2001;0(01):-
Objective The effect of hepatic partial resection for hepatic trauma.Methods Thirty-Six patients with hepatic trauma were operated on the bases of litertures,we elucidated the indication and method of operation and prevention of operative complications .Resuts Three cases died,a death rate of 8 33%,and a cure rate of 91 8%.Conclusion Hepatic partial resection is an effective method for treatment of hepatic trauma.
2.Esophageal stents for treatment of benign and malignant esophageal stenosis
Chinese Journal of Tissue Engineering Research 2011;15(16):3037-3040
BACKGROUND: Recent studies have demonstrated that esophageal stent is made of biodegradable materials and polymers,and satisfactory outcomes regarding its application in animal experiments have been made,but disputation exists. OBJECTIVE: To review the type,clinical application and related complications of esophageal stent. METHODS: Using esophageal stent,clinical application,complications in English and Chinese,manuscripts were retrieved by reading titles and abstracts. The manuscripts that are focused on the type,clinical application,and complications of esophageal stent as well as its application in malignant esophageal stenosis and the manuscripts that were recently published or in high-impact journals were selected. Finally,28 manuscripts were included. RESULTS AND CONCLUSIONS: Esophageal stent placement has become an important mean for esophageal carcinoma in patients who had no surgical conditions to relieve esophageal stenosis. With the development in technique,from initial membrane-free metallic stent,partial membrane-covered metallic stent to whole membrane-covered metallic stent,related esophageal diseases have been effectively solved,but the subsequent complications,such as gastrorrhagia and perforation,gastroesophageal reflux,and re-stenosis,have been not completely solved. Therefore,the therapeutic effects of different stents and the advantages and disadvantages of complications should be fully considered to reduce the complications to a largest extent and finally to improve patient's quality of life.
3.Advances in Microbial Transformation of Phytosterol into Steroid Medicine Intermediates
Yu-Qing ZHANG ; Dong-Qing WANG ;
Microbiology 1992;0(02):-
Microbial selective side-chain degradation of phytosterol,which can obtain the steroid medicine intermediate compounds-androst-4-ene-3,17-dione (4-AD) and androsta-1,4-diene-3,17-dione (ADD),has an important meaning to pharmacy. There is no systematic literature concerned in existence. Its mechnism,approaches,influencing factors and so on over these years were fully reviewed in the paper. The trend of development in the area is expanded.
4.Effects of Angiotensin Ⅱ Receptor 1 Inhibitor on the Proliferation and Apoptosis of Estrogen Induced Human Endometrial Carcinoma Cells
Lili YIN ; Qing YANG ; Yu WANG ; Qing SU
Journal of China Medical University 2010;(6):447-451
Objective To explore the effects of estrogen and angiotensin Ⅱ receptor 1 inhibitor(saralasin)on cell proliferation,cell cycle and apoptosis in endometrial carcinoma cell line HEC-1A.Methods Immunocytochemical assay was applied to detect the expression of AT1-R,PI3K,p-Akt and ERK protein in HEC-1A cell.The effects of estrogen and saralasin on cell proliferation,cell cycle distribution and apoptosis of HEC-1A cell were detected by MTT assay and fluorescence activated cell sorting technique.The expression of ERK and p-Akt protein in HEC-1A cell treated with estrogen and saralasin were analyzed by Western blot.Results The expression of AT1-R,PI3K,pAkt,and ERK protein was found in HEC-1A cell.Estrogen stimulated the proliferation of HEC-1A cell,decreased G0~G1 phase proportion and increased S phase proportion significantly,minimized the number of apoptotic cells,and up-regulated the expression of ERK protein.Saralasin obviously inhibited the proliferation and induced apoptosis of estrogen induced HEC-1A cell,increased G0~G1 phase proportion and decreased S phase proportion,and down-regulated the expression of ERK protein.Conclusion Estrogen could promote the proliferation of HEC-1A cell through AT1-R.AT1-R inhibitor saralasin could inhibit the proliferation and induce the apoptosis of estrogen induced HEC-1A cell.The down-regulation of ERK protein expression by interrupting the mitogen-activated protein kinase(MAPK)signaling pathway might be involved in the possible mechanism.Thus saralasin could be a valid approach to treat ER-negative endometrial carcinoma.
8.A randomized controlled trial of the efficacy of combination of gemcitabine and carboplatin or paclitaxel and combination of paclitaxel and carboplatin in the treatment for advanced non-small cell lung cancer.
Qing GAO ; Fu-yuan WANG ; Hong YU
Chinese Journal of Oncology 2011;33(11):874-876
Adult
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Aged
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Aged, 80 and over
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Anemia
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chemically induced
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Antineoplastic Combined Chemotherapy Protocols
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adverse effects
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therapeutic use
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Carboplatin
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administration & dosage
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Carcinoma, Non-Small-Cell Lung
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drug therapy
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pathology
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Deoxycytidine
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administration & dosage
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analogs & derivatives
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Female
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Follow-Up Studies
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Humans
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Leukopenia
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chemically induced
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Lung Neoplasms
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drug therapy
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pathology
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Male
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Middle Aged
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Neoplasm Staging
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Paclitaxel
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administration & dosage
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Remission Induction
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Survival Rate
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Thrombocytopenia
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chemically induced