Based on experience on medical service drilling for many years,this paper analyses the hardship and complexity of medical service support in high & cold mountainous region.It also puts forward some suggestions in such aspects as integral design,focal points insurance,necessaries reinforcement,preach for popularization and mutual cure training.

The study was proceeded on the mRNA expression of the GULT1 and GLUT4 gene in the alloxan diabetic rats by the technique of dot-blot hybridization analysis. The results showed that the levels of the GLUT4 mRNA expression were reduced in diabetic rats while increased in insulin treated diabetic rats. This suggests that the reduced GLUT4 mRNA expression which could affect the quantity of its posttranslational products may be one of the causes of the insulin resistance.

OBJECTIVE: To summarize the data about endemic fluorosis, and investigate its prevalence and the effects of prevention and cure, so as to suggest more effective measures for the prevention and cure in the future. DATA SOURCES: A computer-based online search of China National Knowledge Infrastructure (CNKI) and VIP Chinese database was undertaken to identify articles about the distribution, monitoring and effects of prevention and cure of endemic fluorosis published in Chinese from January 1995 to March 2006 by using the keywords of "endemic fluorosis, monitor". STUDY SELECTION: Literatures about endemic fluorosis, including mainly brief introduction, practice in prevention and cure, summary of meeting, etc., the repetitive studies were excluded, and only one of them published the latest was involved. DATA EXTRACTION: Totally 25 relevant literatures were collected, and 18 of them were involved, the others were excluded. DATA SYNTHESIS: The monitoring results showed that until the end of the 2004, 44.51％ of the villages, in the drinking water type disease areas with endemic fluorosis, had executed the low-fluorine treatment of water, and 194 villages had been controlled basically; In the coal pollution type disease areas, 24 villages had been controlled basically,25.42％ of the families had reformed the stoves to prevent the coal pollution. The fluorine in water and air had been obviously declined after the improvement, some place had reached the standard of government.The morbidity rate of dental fluorosis in children of 8 to 12 years old was lower than before; The improving condition was good in most disease areas, and part of them had reached the control line; Meanwhile,the problems also existed that the measures of prevention could not befulfilled completely for the short of money, and the role of decreasing fluorine could not be acted completely because of the ill-management after the changed project.CONCLUSION: After the continuous efforts for tens of years, great progress has been obtained in the prevention and cure of endemic fluorosis,and the prevalence rates of dental fluorosis and skeletal fluorosis have reduced obviously, but many problems also exist at the same time. Therefore,the prevention and cure should be reinforced to restrain its prevalence more effectively.

The feasibility to breed gecko, scorpion, centipede,leech and ground beetle together in abreeding shed of our own design with constant temperature was tried for a period of 2 years. Resultsshowed that the animals lead their normal dietetic and living habit satisfactorily, without hibernation andreproduce their offsprings the whole year round. It could be concluded that such breeding scheme is worth-while to advocate for the benefit of those who are engaged in the business of medicinal animal breeding.

Intracranial hypotension syndrome is easily underestimated by doctors and patients,but its occurrence is not infrequent.Primary intracranial hypotension is usually associated with cerebral blood vessel disturbance and infections.Secondary intracranial hypotension is usually secondary to iatrogenic and other diseases or trauma.The main manifestation of intracranial hypotension syndrome is postural headache which may be diagnosed by cerebrospinal fluid pressure measurement during lumber puncture.The headache can disappear by posture adjustment in most children,or by water intake or intravenous administration of hypotonic (0.5％)or saline in serious case.Prognosis is good and precaution is most important for all.

Objective To observe the effect of Danshen injection combined with ulinastatin on the brain protection and inflammatory reaction in patients with Severe traumatic brain injury.Methods 83 cases of patient with Severe traumatic brain injury were randomly divided into the observation group(43 cases)and the control group(40 cases).The control group was given ulinastatin based on conventional treatment,and the observation group was given Danshen injection and ulinastatin based on the control group.For 10 days,the differences of hemodynamic parameters(Qmean、Zc、DR)and serum nerve function indexes(β-EP、DynAl-13、NSE),inflammatory factors(IL-1,IL-6,TNF-α,CRP)between the two groups were be compared.Results ①Comparison of hemodynamic parameters There was significantly difference of Qmean、Zc、DR in these two groups(Fgroup=6.126,5.024,5.621,P<0.05),Qmean was showed a rising trend over time and Zc、DR were showed a declining trend over time(Ftime=10.146,9.247,9.381,P<0.05),the changed amplitude in observation group was higher than the control group(Finteraction=5.357,4.257,4.813,P<0.05); Comparison of nerve function indexes There was significantly difference of β-EP、DynAl-13、NSE in these two groups(Fgroup=5.827,6.294,6.731,P<0.05),they was all showed a reducing trend over time(Ftime=12.613,11.746,9.842,P<0.05),the declined amplitude in observation group was higher than the control group(Finteraction=6.353,7.251,4.284,P<0.05);Comparison of inflammatory factors There was significantly difference of IL-1,IL-6,TNF-α,CRP in these two groups(Fgroup=4.284,5.162,6.174,4.291,P<0.05),they was all showed a rising then reducing trend over time(Ftime=9.163,10.357,13.457,12.434,P<0.05),the changed amplitude in observation group was higher than the control group(Finteraction=4.255,5.242,8.530,7.847,P<0.05).Conclusion Danshen injection combined with ulinastatin has more obviously function of protecting the cerebralfunction and suppressing inflammation in the treatment of Severe traumatic brain injury compared with ulinastatin alone.

Mobile internet terminals were connected to the pharmacy of the hospital to improve the outpatient pharmacy process, building an internet-based pharmacy service model for general tertiary hospitals. This model covered the entire outpatient service, ranging from registration, payment and dispensary at the hospital. It significantly enhanced the efficiency, namely 80. 8% less time for payment, not to mention the free delivery and no waiting time for dispensary.

OBJECTIVE:To deepen clinical pharmacy work and train special clinical pharmacists in the cardiovascular department.METHODS:Clinical pharmacy working mode approved by clinical staff and patients was established for pharmacists by participating in clinical staff's routine work.RESULTS & CONCLUSION:The system of special clinical pharmacists can help improve clinical pharmacists' approval degree and bring their role into full play in drug treatment and pharmaceutical information service.

Objective To investigate the roll of p38MAPK on the expression of osteopontin(OPN) mRNA in cultured renal tubular epithelial cells stimulated by albumin.Methods The normal renal tubular epithelial cells(NRK-52E) were incubated in the presence of albumin(30mg/ml) with or without SB203580,an inhibitor of p38MAPK.Reverse transcriptase polymerase chain reaction(RT-PCR) was performed to determine the expression of OPN mRNA and the p38MAPK phosphorylation was evaluated by Western blot analysis.Results Albumin stimulated the phosphorylation of p38MAPK in a timedependent manner,and up-regulated the expression of OPN mRNA.SB203580 could inhibit the expression of OPN mRNA.Conclusion The p38MAPK signal pathway plays an important roll in OPN mRNA expression stimulated by Albumin.

OBJECTIVE:To observe the efficacy and safety of mesalazine combined with bifidobacterium tetravaccine(live)in the treatment of ulcerative colitis(UC). METHODS:83 UC patients were tandomly divided into control group(42 cases)and test group (41 cases). Control group was orally given 1.0 g Mesalazine enteric-coated tablet,4 times a day;test group was additionally given 1.5 g Bifidobacterium tetravaccine tablet(live),3 times a day. The treatment course fr both group was 6 weeks. The clinical efficacy,and serum high sensitivity C-reactive protein(hs-CRP),interleukin(IL)-4,IL-8 levels before and after treatment and the incidence of ad-verse reactions in 2 groups were observed. RESULTS:After treatment,serum hs-CRP and IL-8 in 2 groups were significantly lower than before,and test group was lower than control group;serum IL-4 level was significantly higher than before,and test group was higher than control group,the differences were statistically significant(P<0.05 or P<0.01). Total effective rate in test group was sig-nificantly higher than control group,the difference was statistically significant(P<0.05). And there was no significant difference in the incidence of adverse reactions (P>0.05). CONCLUSIONS:Mesalazine combined with bifidobacterium tetravaccine (live) is more effective than mesalazine alone UC,with similar safety.