The acute respiratory distress syndrome,a common severe case,can cause life-threaten multiple organ failure.Statins has been clinically applied in prevention of cardiovascular diseases and cerebrovascular disease.Previous studies indicate that statins can modulate inflammatory responses.In this paper,we discussed the mechanisms of statins,mechanisms and application of statins in acute lung injury and acute respiratory distress syndrome,and the effectiveness and safety of statins.

Objective To study the clinical application of 3-dimensional arterial spin labeling technology (3D-ASL) in brain tumors.Methods Twenty patients with the pathological diagnosis of brain tumors were selected in this study,with low grade glioma in 4 cases,the high grade glioma in 2 cases,lymphoma in 1 case,metastatic tumor in 7 cases,meningioma in 6 cases.All patients were appLIed preoperative 3D-ASL and dynamic contrast-enhanced perfusion magnetic sensitive (DSC) MR imaging line two methods,to analyze the value of 3D-ASL in brain tumors.Results 3D-ASL examination lesions in patients with brain tumors might be displayed in high or low perfusion; 3D-ASL and DSC were obtained from tumor tissue blood supply,the local relative cerebral blood flow (rCBF),there was no significant difference (P ＞ 0.05).The high grade glioma in 3D-ASL image showed a high perfusion,rCBF was 3.0 ± 1.3; Low grade gliomas showed low perfusion,rCBF was 0.6 ± 0.2,the rCBF between the high-and low-grade gliomas was significantly different (P ＜ 0.01).Metastatic tumor 3D-ASL showed ring high perfusion,central necrosis and edema area of low perfusion.Lymphoma 3D-ASL showed slightly higher perfusion.Meningioma showed high perfusion,and highest rCBF,3.5 ± 1.9.Conclusions 3D-ASL in the diagnosis of brain tumors,has high repeatability,non-invasive,without contrast agent.3D-ASL can be further developed into the brain blood flow dynamics of conventional evaluation methods,and can be used for brain tumors level assessment,has broad application prospects.

This paper started from the relevant concepts of nursing students'professional values , discussed the core value of nursing profession and nursing students occupational choice , which are included in the nursing students'professional values .Based on the current status , the author proposed some suggestions: emphasizing on curriculum and teaching content reform , strengthening the guiding role of the teachers;cultivating professional val-ues in practice; improving evaluation system; implementing sectional training plan , etc.In addition, the values education in nursing students should make efforts at national , hospital and school levels .

Objective To explore the impact of health education on negative mood,social support and life quality of patients with breast cancer.Methods 90 patients with breast cancer receiving chemotherapy were divided into the observation group and the control group randomly,and each group with 45.The regular health education was given to the control group,and personalized health education was provided to the observation group and their related family member,the measures included mental communication,psychological counseling and life guidance.SAS,SDS,SSRS and QOL were carried out at two time points:the time when admission to hospital and 4 weeks after admission.Results Before health education,there were no statistical significance between the observation group and the control group on anxiety,depression,social support and life quality.After health education,the observation group was better than the control group in scores of anxiety,depression,social support and life quality.Conclusions The health education given simultaneously to the patients and their family members can improve their negative mood,increase their social support,and improve their life quality.

Objective:To establish the parallel bi-vein graft with valves animal model and to seek a new surgical method for patients with deep valvular incompetence.Methods:The parallel bi-vein with valves autogenic graft animal model was established in 12 rabbits by microsurgery and the hemorheology and hemodynamics were examined by real time color-duplex scanning and phlebography.Results:Among all of the 12 rabbits, autogenic graft of the parallel bi-vein with valves animal model was successfully established and was under observation for 4 weeks postoperatively.Only in 1 rabbit it was obstructed after 4 weeks.The rest remained unobstructed and were kept in favorable configuration and steady blood stream with laminar flow.Conclusion:The autogenic graft parallel bi-vein containing valves by microsurgery technique in rabbits is feasible.The opretion may be a feasible and promising method for clinical patients with chronic venous insufficiency in lower limb.

OBJECTIVE To discuss rational layout of Sterilizing and Supply Room in the Department of Stomatology and its scientific utilization of sterilizing equipment which ensure safe medical treatment of patients. METHODS Funds should be invested to the Stomatology Department according to plan and environment and equipment should be transformed. RESULTS Transformed conditions of Sterilizing and Supply Room had conformed to Operation Rules of Sterilization of Dental Medical Instruments in Medical Institutions promulgated by the Ministry of Health.One patient could certainly use his own medical goods with absolute sterilization.This not only reduced opportunities of cross infection,but also protected and made things convenient for medical personnel. CONCLUSIONS The fundamental guarantee of safe medical treatment of patients is rational layout of Sterilizing and Supply Room in the Stomatology Department and rational allocation and scientific utilization of sterilizing equipment.

Objective To discuss the difference of preoperative examination and matters needing attention between osteoarthritis(OA)and rheumatoid arthritis(RA)patients who received total knee replacement(TKR).Methods Preoperative examination results were analyzed retrospectively between OA patients(362 cases)and RA patients(91 cases)who received TKR.Results The age of OA patients was significantly higher than RA patients[(66.55±7.78)years vs.(58.93±13.46)years,P＜0.05].There was significant difference in rate of diabetes between OA and RA patients[26.52％(96/362)vs.37.36％(34/91),P＜0.05].There was no significant difference in the rate of lumbar vertebrae disease between OA and RA patients[33.43％(121/362)vs.23.08％(21/91),P＞0.05].The body mass index,haematocrit and hemoglobin in OA patients were significantly higher than those in RA patients[(27.71±3.98)kg/m2 vs.(24.37±4.30)kg/m2,0.38±0.05 vs.0.33±0.06,(130.17±17.59)g/L vs.(111.45±18.56)g/L,P＜0.01].The erythrocyte sedimentation rate,C-reactive protein and D-dimer in OA patients were significantly lower than those in RA patients[(27.77±27.66)mm/1 h vs.(59.76±32.00)mm/1 h,(17.23±27.66)mg/L vs.(30.00±32.27)mg/L,(268.54±299.83)μ g/L vs.(990.09±550.91)μg/L,P＜0.01 or＜0.05].The rate of using glucocorticoid in RA patients was significantly higher than OA patients[8.8％(8/91)vs.0,P＜0.01].There was no significant difference in the rate of urinary system infection(P＞0.05).Conclusions The preoperative examination is found significantly different between OA and RA patients who received TKR.According to different focuses on,dealing with various kinds of complications and correct guidance on preoperative treatment,can ensure the safety of operation.

Objective To investigate the curative efficacy of safflower yellow sodium chloride in the treat-ment of acute myocardial infarction (AMI)and its effects on cardiac function and oxidative stress.Methods 110 cases of AMI meeting the inclusion criteria were randomly divided into two groups equally.The control group was given conventional drug treatment and percutaneous coronary intervention (PCI),while the observation group was given con-ventional drug treatment and PCI in combination with safflower yellow sodium chloride.Then,the curative efficacy, indices of cardiac function and oxidative stress were observed and compared.Results The observation group had a total effective rate of 94.5%,which was significantly higher than 81.8% in the control group (χ2 =4.94,P =0.026).After the treatment,SV (t =3.23,P =0.002),CO(t =3.82,P =0.000)and LVEF (t =3.14,P =0.002) in the observation group were significantly higher than those in the control group (all P <0.05 ).As to oxidative stress,in comparison with the control group,SOD (t =8.42,P =0.000)was significantly higher and MDA (t =3.99, P =0.000)was significantly lower in the observation group (all P <0.05 ).Conclusion Adjuvant treatment of safflower yellow sodium chloride for AMI was effective,which could significantly increase curative efficacy,improve cardiac function and alleviate oxidative stress.

Aim: To develop marine microporous osmotic pump tablets and to investigate drug release in vitro of the optimized formulation and the release mechanism.Methods: Wet granulation and film-coating were used to develop marine micro-osmotic pump tablets.In vitro release studies were applied to evaluate the impacts of various factors on the release of the formulation.Central-composite design was exploited to aid the optimization of the formulation,and the mechanism of in vitro release was characterized.Results: There existed fairly good reproducibility in the preparation of marine micro-osmotic pump tablets.It was found that no change in the release rate of the tablets were elicited by the pH of the release media,the rotating speed selected,the hardness of the tablet core,and the amount of the plasticizer incorporated into the coating formulation.It was proved that the release of marine micro-osmotic pump tablets was closely related to the magnitudes of NaCl amount in the tablet core and the pore former in the coating formulation as well as the coating level.In addition,there existed 12-hr zero-order kinetics in the in vitro release study of the tablets.Moreover,it was shown that the osmotic pressure-controlled delivery is greatly responsi-ble for the release of the developed tablets.Conclusion: The prepared marine microporons osmotic pump tablets are expected to be a new sustained-release medication.

Objective To investigate the relationship between occurrence of healthcare-associated infection (HAI)and seasonal change,so as to provide the basis for seasonal HAI prevention and control.Methods The occurrence of HAI among inpatients in a hospital between 2010 and 2013 was analyzed retrospectively.Results Of 303 371 patients,10 376 developed 12 919 cases of HAI,the incidence of HAI was 3.42%,infection case incidence was 4.26%.The highest inci-dence of HAI occurred in the fourth quarter(3.76%)and lowest in the second quarter (3.20%)(P <0.01);the main HAI site was lower respiratory tract (39.79%),followed by upper respiratory tract (13.17%),blood stream (10.39%), surgical site (8.60%),and urinary tract (7.91%).Patients in the following departments were with HAI rates of >5%:intensive care unit(ICU,24.61%),hematology(17.47%),rehabilitation(13.16%),neurosurgery(9.27%),infectious diseases (9.17%),cardiothoracic surgery(7.67%),and hepatobiliary surgery(5.13%),the main HAI sites in patients in ICU,department of neurosurgery were lower respiratory tract,blood stream,and urinary tract.Conclusion The occu-rrence of HAI is closely related with seasonal change,appropriate control measures should be taken according to seasonal change and sites of high HAI rates,so as to reduce the occurrence of HAI.