Acupuncture Points ; Acupuncture Therapy ; Female ; Hirschsprung Disease ; therapy ; Humans ; Infant

This article summarizes the literature about studies onToll-like receptor 2and acupuncture points and explores thecorrelationand action of Toll-like receptor 2inacupuncture information start-up and conduction mechanism from the biological characteristics of Toll-like receptor 2and the relationship of Toll-like receptor 2-mediated signal pathways tomast cells, acupuncture effects and the immuno-neuro-endocrine network.

Objective To observe the treatment efficacy of piperacillin/tazobactam regime for P.aeruginosa infection formulated by the method of the ratio of T above MIC (T>MIC%).Methods 59 hospitalized patients with P.aeruginosa infection were diagnosed by etiological diagnosis which was sensitive to piperacillin/tazobactam from Jan.to April.2015.Before treatment, all patients were randomly divided into the control group and the test group.Patients in the control group were treated with 4.5 g piperacillin/tazobactam once and repeated every six hours.Patients in test group were treated with 4.5 g piperacillin/tazobactam once and repeated every twelve hours.The two groups were injected by 15 mg/kg amikacin once a day based on the above program.The other treatments were kept to be same.Results Between the two groups, the clinical efficiency rate and total hospital stay were equivalent, bacterial clearance rate and incidence of adverse reactions were similar, there were no difference between CRP and APACHE Ⅱ score before and after treatment.Conclusion The regime of piperacillin/tazobactam for P.aeruginosa infection formulated by the method of the ratio of T above MIC (T>MIC%)was safe, effective and feasible.

Patients with breast hypertrophy often have breast and nipple-areolar complex (NAC) skin paresthesia, shoulder or back pain, eczema, reduced mobility, and other problems, which seriously decline the quality of life. With the improvement of patients’ requirements for life quality, researchers have gradually paid attention to the importance of breast and NAC sensation. This paper introduced Semmes-Weinstein monofilaments examination (SWME), pressure-specified sensory device (PSSD), and the hypotheses of breast and NAC sensory change in patients with mammary hypertrophy. The main factors causing sensory change after breast reduction surgery were also summarized. In these patients, the sensory change of the nipple and areola are not necessarily consistent. Pedicle selection could probably affect postoperative breast and NAC sensation. Notably, the superior pedicle and superolateral pedicle could bring some risks to the innervation of NAC, which might cause a significant decrease in postoperative skin sensitivity within a certain period. In addition, patients with larger breasts probably could benefit more from surgery, and the resection volume was not significantly associated with sensory change.

Patients with breast hypertrophy often have breast and nipple-areolar complex (NAC) skin paresthesia, shoulder or back pain, eczema, reduced mobility, and other problems, which seriously decline the quality of life. With the improvement of patients’ requirements for life quality, researchers have gradually paid attention to the importance of breast and NAC sensation. This paper introduced Semmes-Weinstein monofilaments examination (SWME), pressure-specified sensory device (PSSD), and the hypotheses of breast and NAC sensory change in patients with mammary hypertrophy. The main factors causing sensory change after breast reduction surgery were also summarized. In these patients, the sensory change of the nipple and areola are not necessarily consistent. Pedicle selection could probably affect postoperative breast and NAC sensation. Notably, the superior pedicle and superolateral pedicle could bring some risks to the innervation of NAC, which might cause a significant decrease in postoperative skin sensitivity within a certain period. In addition, patients with larger breasts probably could benefit more from surgery, and the resection volume was not significantly associated with sensory change.

Clinically,pancreatic cancer is a highly aggressive tumor,and neurotropic growth is an important biological feature of pancreatic cancer.Nerve invasion brings great pain burden to patients,and it seriously affects the quality of life and the will to survive of patients.The"three-step analgesia principle"for the management of cancer pain proposed by World Health Organization(WHO)is a traditional therapeutic regimen for cancer pain.However,because of its obvious toxic side effects,poor efficacy,easy addiction,easy drug resistance,non-standard medication of clinical physicians,etc.,the"three-step analgesia principle"is unable to meet the needs of the patient's condition..In recent years,with the development of interventional technology and the development of extensive clinical trials,the interventional means,which is regarded as the"fourth step"of cancer pain management,has achieved great clinical effect,it includes various therapeutic methods and imaging-guided techniques such as neural destruction(denervation),125I particle implantation,patient-controlled analgesic pump technology,implantation of intrathecal drug infusion system,etc.,and clinical practice has proved that these techniques have significant clinical efficacy and they can provide a convenient,safe and effective treatment method for HCC patients.

Objective To explore the effectiveness of FOCUS-PDCA(find,organise,clarify,understand,select,plan,do,check and act)mode in prevention and treatment of incontinence-associated dermatitis(IAD)in emergency intensive care unit(EICU),and to reduce the incidence of IAD.Methods A pre-post control study design was employed in this study.Inpatients admitted to the EICU of the hospital between 1st January and 31st December 2022 were enrolled as study subjects.A total of 169 patients in EICU between January and June 2022 were assigned as a control group,while 197 patients in EICU between July and December 2022 as an trial group.Patients in the control group received conventional quality management,while those in the trial group were treated with the FOCUS-PDCA mode.The two groups were compared in terms of incidence of IAD,the knowledge,trust and behaviour scores of the nurses,and satisfaction from the communications with nurses before and after implementation of the FOCUS-PDCA mode.Results All patients in the two groups had completed the study.Following the implementation of FOCUS-PDCA mode,patients in the trial group exhibited a significantly decrease in incidence of IAD from 10.06%(trial group)to 1.52%(control group),significant increase of scores on the IAD knowledge,behaviour and satisfaction from communications with the nurses,from(36.07±3.98),(16.56±2.15)and(25.15±5.21),to(38.59±3.72),(18.07±1.66),and(30.67±5.84),respectively(all P<0.05).Conclusion FOCUS-PDCA mode can effectively decrease the incidence of IAD,enhance the IAD knowledge and behaviour of nurses and gain satisfactions from communication with nursing staff and clinical quality,thereby improving therapeutic outcomes.

The stimulator of interferon genes(STING),an integral adaptor protein in the DNA-sensing pathway,plays a pivotal role in the innate immune response against infections.Additionally,it presents a valuable therapeutic target for infectious diseases and cancer.We observed that fangchinoline(Fan),a bis-benzylisoquinoline alkaloid(BBA),effectively impedes the replication of vesicular stomatitis virus(VSV),encephalomyocarditis virus(EMCV),influenza A virus(H1 N1),and herpes simplex virus-1(HSV-1)in vitro.Fan treatment significantly reduced the viral load,attenuated tissue inflammation,and improved survival in a viral sepsis mouse model.Mechanistically,Fan activates the antiviral response in a STING-dependent manner,leading to increased expression of interferon(1FN)and interferon-stimulated genes(ISGs)for potent antiviral effects in vivo and in vitro.Notably,Fan interacts with STING,preventing its degradation and thereby extending the activation of IFN-based antiviral responses.Collectively,our findings highlight the potential of Fan,which elicits antiviral immunity by suppressing STING degra-dation,as a promising candidate for antiviral therapy.

Objective:To establish the connection between the superficial inferior epigastric artery (SIEA) system and patients’ body mass index (BMI) statistics. It could provide a reference for the tendentious choice of preoperative reconstruction scheme.Methods:Female patients with unilateral breast cancer after radical mastectomy were included in this study from August 2008 to June 2018 in the Department of Aesthetic and Reconstructive Breast Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College. The computed tomography angiography data before reconstruction were analyzed by Onis 2.5 software, and the SIEA diameter was measured. Pearson correlation analysis was performed for the correlation between the SIEA diameter and BMI.Results:A total of 19 patients, aged (43.0±8.1) years, ranging from 30 to 60 years old, with height of (1.61±0.05) m, body mass of (62.9±8.6) kg and BMI of (24.4±3.3) kg/m 2 were included. There were 20 sides of abdominal wall in 19 patients identified with SIEA, of which 18 cases were unilateral and one case was bilateral. The diameter of SIEA was (1.75±0.54) mm, which was high linear correlation with BMI ( r=0.85, P<0.001); when BMI ≥24 kg/m 2, SIEA≥1.5 mm could be satisfied. Conclusions:Preoperative CTA data of the patients with no previous potential factors affecting the diameter of SIEA indicated that there was SIEA on the donor side. When BMI was no less than 24 kg/m 2, the application of the SIEA flap in breast reconstruction could be a theoretical option worthy of trying.

Objective:To establish the connection between the superficial inferior epigastric artery (SIEA) system and patients’ body mass index (BMI) statistics. It could provide a reference for the tendentious choice of preoperative reconstruction scheme.Methods:Female patients with unilateral breast cancer after radical mastectomy were included in this study from August 2008 to June 2018 in the Department of Aesthetic and Reconstructive Breast Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College. The computed tomography angiography data before reconstruction were analyzed by Onis 2.5 software, and the SIEA diameter was measured. Pearson correlation analysis was performed for the correlation between the SIEA diameter and BMI.Results:A total of 19 patients, aged (43.0±8.1) years, ranging from 30 to 60 years old, with height of (1.61±0.05) m, body mass of (62.9±8.6) kg and BMI of (24.4±3.3) kg/m 2 were included. There were 20 sides of abdominal wall in 19 patients identified with SIEA, of which 18 cases were unilateral and one case was bilateral. The diameter of SIEA was (1.75±0.54) mm, which was high linear correlation with BMI ( r=0.85, P<0.001); when BMI ≥24 kg/m 2, SIEA≥1.5 mm could be satisfied. Conclusions:Preoperative CTA data of the patients with no previous potential factors affecting the diameter of SIEA indicated that there was SIEA on the donor side. When BMI was no less than 24 kg/m 2, the application of the SIEA flap in breast reconstruction could be a theoretical option worthy of trying.