1.Clinical features and imaging findings in pulmonary capillary hemangiomatosis: report of two cases and a pooled analysis.
Wan-Mu XIE ; Hua-Ping DAI ; Mu-Lan JIN ; Zhen WANG ; Yuan-Hua YANG ; Zhen-Guo ZHAI ; Chen WANG
Chinese Medical Journal 2012;125(17):3069-3073
BACKGROUNDPulmonary capillary hemangiomatosis (PCH) is a rare disease and no Chinese case has been reported yet. The disease is often misdiagnosed and its clinical characteristics are incompletely described. The aim of this study was to describe two Chinese cases and to clarify the clinical and radiographic parameters of patients with PCH.
METHODSTwo PCH cases were presented and other cases were searched from the English literature. All available clinical and radiographic data were collected from 62 literature reported PCH cases. A pooled analysis of total 64 cases was made.
RESULTSDyspnea and hemoptysis were the most common clinical symptoms of PCH. Pulmonary hypertension (PH) was found in 78% of the reported cases. PCH typically showed characteristic diffuse or patchy ground-glass opacities (GGOs) and/or multiple ill-defined centrilobular nodules in the computed tomography.
CONCLUSIONSThe diagnosis of PCH requires a high clinical suspicion. However, both clinical presentations and radiographic studies often provide clues to the diagnosis, which may prompt early lung biopsy for a definite diagnosis.
Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Female ; Hemangioma, Capillary ; complications ; diagnosis ; Humans ; Lung Neoplasms ; complications ; diagnosis ; Male ; Middle Aged ; Tomography, X-Ray Computed
2.Serum Bilirubin and 6-min Walk Distance as Prognostic Predictors for Inoperable Chronic Thromboembolic Pulmonary Hypertension: A Prospective Cohort Study.
Juan-Ni GONG ; Zhen-Guo ZHAI ; Yuan-Hua YANG ; Yan LIU ; Song GU ; Tu-Guang KUANG ; Wan-Mu XIE ; Ran MIAO ; Chen WANG ;
Chinese Medical Journal 2015;128(23):3125-3131
BACKGROUNDInoperable chronic thromboembolic pulmonary hypertension (CTEPH) is a severe clinical syndrome characterized by right cardiac failure and possibly subsequent liver dysfunction. However, whether serum markers of liver dysfunction can predict prognosis in inoperable CTEPH patients has not been determined. Our study aimed to evaluate the potential role of liver function markers (such as serum levels of transaminase, bilirubin, and gamma-glutamyl transpeptidase [GGT]) combined with 6-min walk test in the prediction of prognosis in patients with inoperable CTEPH.
METHODSFrom June 2005 to May 2013, 77 consecutive patients with inoperable CTEPH without confounding co-morbidities were recruited for this prospective cohort study. Baseline clinical characteristics and 6-min walk distance (6MWD) results were collected. Serum biomarkers of liver function, including levels of aspartate aminotransferase, alanine aminotransferase, GGT, uric acid, and serum bilirubin, were also determined at enrollment. All-cause mortality was recorded during the follow-up period.
RESULTSDuring the follow-up, 22 patients (29%) died. Cox regression analyses demonstrated that increased serum concentration of total bilirubin (hazard ratio [HR] = 7.755, P < 0.001), elevated N-terminal of the prohormone brain natriuretic peptide (HR = 1.001, P = 0.001), decreased 6MWD (HR = 0.990, P < 0.001), increased central venous pressure (HR = 1.074, P = 0.040), and higher pulmonary vascular resistance (HR = 1.001, P = 0.018) were associated with an increased risk of mortality. Serum concentrations of total bilirubin (HR = 4.755, P = 0.007) and 6MWD (HR = 0.994, P = 0.017) were independent prognostic predictors for CTEPH patients. Patients with hyperbilirubinemia (≥23.7 μmol/L) had markedly worse survival than those with normobilirubinemia.
CONCLUSIONElevated serum bilirubin and decreased 6MWD are potential predictors for poor prognosis in inoperable CTEPH.
Aged ; Antihypertensive Agents ; therapeutic use ; Bilirubin ; blood ; Exercise Test ; Female ; Humans ; Hypertension, Pulmonary ; blood ; drug therapy ; pathology ; Male ; Middle Aged ; Prognosis ; Prospective Studies
3.Prevalence of deep venous thrombosis in patients with acute exacerbation of chronic obstructive pulmonary disease.
Sheng-chen DUAN ; Yuan-hua YANG ; Xu-yan LI ; Xiao-ning LIANG ; Rui-jun GUO ; Wan-mu XIE ; Tu-guang KUANG ; Hua-ping DAI ; Chen WANG
Chinese Medical Journal 2010;123(12):1510-1514
BACKGROUNDAcute exacerbation of chronic obstructive pulmonary disease (COPD) is always associated with a high incidence and mortality. Because of the presence of some concomitant risk factors such as immobilization, bronchial superinfection, patients who are admitted for acute exacerbations of COPD are generally considered to be at moderate risk for the development of venous thromboembolism. In this study, we investigated the prevalence and the clinical manifestations of deep venous thrombosis (DVT) in patients with acute exacerbation of COPD.
METHODSFrom March 2007 to March 2009, 520 consecutive patients were included in this study. On admission, color Doppler ultrasound of lower extremities in all cases was performed for diagnosing DVT. Patients with DVT were compared with those without DVT from such aspects as demographics, symptoms, physical signs and risk factors.
RESULTSAmong the 520 patients, DVT was found in 46 cases (9.7%). In patients with DVT, the duration of hospitalization was longer (P = 0.01), and the mechanical ventilation requirement increased (P < 0.001). Other indicators for patients with more possibility of DVT were immobility exceeding 3 days (P < 0.001); pneumonia as concomitance (P = 0.01); respiratory failure type II (P = 0.013); current smoking (P = 0.001). Lower extremity pain was more common in DVT cases in comparison to those without DVT (34.8% vs. 15.2%, P = 0.01).
CONCLUSIONSThe acute exacerbation of COPD patients, who were immobilized for over 3 days, complicated by pneumonia and had respiratory failure type II, had a higher risk of DVT. In addition, DVT detection awareness should be increased in cases that had a lower extremity pain.
Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive ; complications ; Risk Factors ; Venous Thrombosis ; epidemiology ; etiology
4.Intervention with Schistosoma japonicum cysteine protease inhibitor for treatment of lipopolysaccharide-induced sepsis in mice.
Yong-Kun WAN ; Hui-Hui LI ; Lin ZUO ; Xiao-Li WANG ; Li-Yuan WANG ; Wen-Xin HE ; Hui JIANG ; Shou-Xiang WANG ; Jie SHENG ; Min ZHANG ; Hai-Chun QIAN ; Fang-Fang YANG ; Hong XIE ; Shi-Fang GAO ; Qiang FANG ; Xiao-di YANG ; Mu-Ling LIU
Journal of Southern Medical University 2018;38(5):625-629
OBJECTIVETo observe the effect of Schistosoma japonicum cysteine protease inhibitor (rSjCystatin) for treatment of lipopolysaccharide (LPS)-induced sepsis in mice.
METHODSAfter a week of adaptive feeding, 54 BALB/c mice were randomly divided into normal control group (group A), sepsis group (group B), and rSjCystatin intervention group (group C). The mice in group A received an intraperitoneal injection of PBS (100 µL), and those in groups B and C were injected with PBS (100 µL) containing LPS (10 mg/kg); the mice in group C were also intraperitoneally injected with 25 µg sjCystatin in 100 µL PBS 30 min after LPS injection. From each group, 10 mice were randomly selected 24 h after PBS or LPS injection for detecting serum levels of TNF-α, IL-6, and IL-10 using ELISA and the levels of ALT, AST, BUN, and Cr using automatic biochemical analyzer; the pathological changes in the liver, lung and kidney were observed with HE staining. The remaining 8 mice in each group were used for observing the changes in the general condition and the 72-h survival.
RESULTSThe 72-h survival rates of the mice was 100% in group A, 0 in group B, and 36% in group C, showing a significant difference among the 3 groups (P<0.05). Compared with those in group A, the mice in group B exhibited obvious liver, lung, and renal pathologies with increased levels of ALT, AST, BUN, Cr, IL-6, and TNF-α (P<0.05). Treatment with sjCystatin significantly lessened LPS-induced organ pathologies, lowered the levels of liver and renal functional indexes and the pro-inflammatory cytokines, and increased the serum level of IL-10 in the mice (P<0.05).
CONCLUSIONSjCystatin can produce a significant therapeutic effect on sepsis induced by LPS in mice.
5. Interpretation of expert ideas in the Sixth World Symposium of Pulmonary Hypertension(Ⅳ)——update on the diagnosis and treatment strategies of chronic thromboembolic pulmonary hypertension
Chinese Journal of Practical Internal Medicine 2019;39(11):967-971
Chronic thromboembolic pulmonary hypertension(CTEPH)is a complication of pulmonary embolism. It is emphasized that the need for a multidisciplinary team involving diagnosis and treatment. The understanding and management of CTEPH have been updated on the 6 th World Symposium on Pulmonary Hypertension(WSPH)in 2018. Key diagnostic steps in early identification and accurate diagnosis are emphasised. An updated treatment algorithm is proposed. Combined with clinical practice, the article will give an interpretation of diagnosis and treatment of CTEPH based on this consensus opinions.
6.Effect of Music Therapy on Cognition and Emotion for Stroke Patients
Jun XIE ; Zao-mu HAN ; Wan-ling YIN
Chinese Journal of Rehabilitation Theory and Practice 2019;25(9):1075-1078
Objective:To explore the effect of early cognitive rehabilitation combined with music therapy on cognitive function, activities of daily living (ADL) and psychology in stroke patients. Methods:From March, 2016 to September, 2017, 56 stroke patients were were randomly divided into control group (
7.Endovascular Catheter-guided Forceps Biopsy for the Diagnosis of Suspected Pulmonary Artery Sarcoma: A Preliminary Study of Eight Cases.
Wan-Mu XIE ; Zhen-Guo ZHAI ; Le-Feng WANG ; Jun WAN ; Yuan-Hua YANG ; Chen WANG ;
Chinese Medical Journal 2016;129(18):2246-2249
Adult
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Aged
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Biopsy
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methods
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Female
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Humans
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Male
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Middle Aged
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Pulmonary Artery
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pathology
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Sarcoma
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diagnosis
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Vascular Neoplasms
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diagnosis
8.Jiawei Erzhiwan improves menopausal metabolic syndrome by enhancing insulin secretion in pancreatic β cells.
Xiao-Meng WAN ; Mu ZHANG ; Pei ZHANG ; Zhi-Shen XIE ; Feng-Guo XU ; Ping ZHOU ; Shi-Ping MA ; Xiao-Jun XU
Chinese Journal of Natural Medicines (English Ed.) 2016;14(11):823-834
Menopausal metabolic syndrome (MMS) is a series of syndrome caused by ovarian function decline and hormone insufficiency, and is a high risk factor for cardiovascular diseases (CVD) and type II diabetes mellitus (T2DM). Erzhiwan (EZW), composed of Herba Ecliptae and Fructus Ligustri Lucidi, is a traditional Chinese herbal formula that has been used to treat menopausal syndrome for many years. We added Herba Epimedii, Radix Rehmanniae, and Fructus Corni into EZW, to prepare a new formula, termed Jiawei Erzhiwan (JE). The present study was designed to determine the anti-MMS effects of JE using ovariectomized (OVX) adult female rats that were treated with JE for 4 weeks, and β-tc-6 cells and INS cells were used to detected the protect effectiveness of JE. Our results showed JE could increase insulin sensitivity and ameliorated hyperlipidemia. Metabolomics analysis showed that the serum levels of branched and aromatic amino acids were down-regulated in serum by JE administration. Moreover, JE enhanced the function of islet β cells INS-1 and β-tc-6, through increasing the glucose stimulated insulin secretion (GSIS), which was abolished by estrogen receptor (ER) antagonist, indicating that JE functions were mediated by ER signaling. Additionally, JE did not induce tumorigenesis in rat mammary tissue or promoted proliferation of MCF-7 and Hela cells. In conclusion, our work demonstrated that JE ameliorated OVX-induced glucose and lipid metabolism disorder through activating estrogen receptor pathway and promoting GSIS in islet β cells, thus indicating that JE could be a safe and effective medication for MMS therapy.
Animals
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Drugs, Chinese Herbal
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administration & dosage
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Female
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Glucose
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metabolism
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Humans
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Insulin
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metabolism
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Insulin Secretion
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Insulin-Secreting Cells
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drug effects
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metabolism
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Menopause
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drug effects
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metabolism
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Metabolic Syndrome
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drug therapy
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metabolism
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Mice
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Rats
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Rats, Sprague-Dawley
9.Pulmonary Hypertension in Glycogen Storage Disease Type II.
Hui-Ping LI ; Wan-Mu XIE ; Xu HUANG ; Xin LU ; Zhen-Guo ZHAI ; Qing-Yuan ZHAN ; Chen WANG
Chinese Medical Journal 2018;131(11):1375-1376