During the last three years, from 1967 to 1970, three hundred and three cases of psoriasis were treated by Goeckrman's regimen and oral methotrexate, 270 cases and 33 cases respectively. Authors evaluated the clinical effectivness and side effect of methotrexate and it compared with the result of Goeckermans method and review about the articles. Of the 303 psoriatics, 140 were male(44%) and 163 were female(55.6%). The majority of the primary manifestation appeared in 16 to 30 year .age group with maximal occurence in the 16 year to 20 year age group (53 cases), but 33 cases were noted below the 10 years old age(Fig.2). The duration of the disease in most cases was 1 to 10 years,but the highest number, in 72 cases, was 1 to 5 years group(Fig 3 A, 3 B). 40 cases was in below 6 months. The methotrexate were administered orally, 2. 5 mg. tab., twice daily(5 mg) for 5 to 7 days, followed by 3 to 5 days resting in accordance with the, patient's condittion. The Goeckerman regirnen of 2% coal tar and 2% salicylic acid in vaselin applied to whole skin lesions in the night and the excess tar was removed frorn skin by gentle wiping with a gauze pat, saturated with Arachis oil, in the next morning, follawed by ultra-violet ray irradiation for 30 second at first day, then the dose increased 30 second daily to reach 5 min. After the ultra-violet irradiation bath was done, and one hour later 2% coal tar and 2% salicylic acid vaselin were applied again. These schedules were repeated 2 to 3 courses (20 to 30 days) in mast cases. In occasion of Goeckerman treatment, among the completely cleared 93 cases during the preveous treatment, the most cases were recurred within 3 to 12 months but 16 cases within 1 month. In occasion of methotrexate, the lesions recurred within 6 months to 2 years in 17 cases of the 33 cases, but 3 cases were within one month after completely cured preveously. The starting of remission, in Goeckerman methods, was noted within 7 to 14 days in most cases(13 cases), and in 3 cases it started within 3 to 4 days. And the completely clearing of the lesions noted within 20 to 25 days in most cases(16 to 21 cases). The starting of remission, in methotrexate treatment of 33 cases, was occurred within 1 to 2 weeks in most cases(27 cases), and completely clearing of lesions noticed within 14 ta 20 days in 28 cases. But in 2 cases it needed only 7 days to make completely clearing the skin lesions. The side effects of the Goeckerman's method were as follow : 1) Contact dermatitis due to tar hypersensitivity in 3 cases. 2) Mild local burn due to over dose irradiation of ultra-violet ray in 5 eases, otherwise no appreciable side effects were noted. The side effecst of methotrexate were noted in 17 cases among the 33 cases. 1) Aphtous ulcer in 4 cases, 2) Peptic ulcer in one case, 3) Tinitus in one case, 4) Other side effects such as dizziness, loss of appetite, headache, fatiguability were notable in 10 cases. 5) In addition to above mentioned sidle effects the blood chemistry include L.P.T., wbc count, platelet count, ESR, Hgb, and creatinine showed as follow before and after administration of methotrexate. a) The white blood cells, platelet count were tend to decrease after the administration of methotrexate than before one. b) Among 33 cases the SGPT levels were checked in 16 cases, and in most cases it raised more and less than before the administration of methotrexate, but only 8 cases were ahove the normal ranges(35 units). The SGOT level also raised after one course, but only 8 cases were above normal ranges(40 units). c) Hgb, ESR, creatinine showed no remarkable changes. In many references the effects and side effects of methotrexate were discussed, but their view were not uniform and variable. In the clinical improvement, recurrency, and side effects, the large single weekly dose of methotrexate had no fundamental differences compare with the author's small daily doses. We agree with the Ryan's report(11), in which the large single dose were not always safer and more effective than the small dose. Still there are many important problems to study about the dosage, interval of administration, and resting period in the treatment of psoriasis with methotrexate.
Alanine Transaminase ; Appetite ; Appointments and Schedules ; Arachis ; Aspartate Aminotransferases ; Baths ; Burns ; Chemistry ; Child ; Coal Tar ; Creatinine ; Dermatitis, Contact ; Dizziness ; Headache ; Humans ; Hypersensitivity ; Leukocytes ; Methotrexate* ; Peptic Ulcer ; Platelet Count ; Psoriasis* ; Salicylic Acid ; Skin ; Ulcer ; Ultraviolet Rays

Osteoid Osteoma occurs anywhere in skeleton. They are most common in lower extremity, particularly femur about 40%. Two-thirds of femoral lesions is in the intertrochanter or intracapsular regions of the hip. The lesion is usually cortical and may extend into the periosteal or endosteal surface of the bone. It is rare in the cancellous bone. We experienced a case of osteoid osteoma in intertrochanteric cancellous portion of the femur in 50 year old man. Many complained right hip pain worsend three weeks before his visit. Radiograph shows sclerosis around a lucent nidus in cancellous portion. The lesion did not extend to the endosteal surface. We have removed nidus and surrounding reactive portion completely with curettage. Follow up radiographic results after 20 weeks, showed no evidence of recurrence.
Adult* ; Curettage ; Femur* ; Follow-Up Studies ; Hip ; Humans ; Lower Extremity ; Middle Aged ; Osteoma, Osteoid* ; Recurrence ; Sclerosis ; Skeleton

Spinal stenosis is defined as any type of narrowing of the main spinal canal, nerve canal or foramina caused by bony or sourrounding soft tissues. Its pressure symptoms are characterized by ill localized back pain, and usually bilateral chronic sciatica. During the past 80 years, the knowledge subjected to the spinal stenosis has been inproved but still many problems are remaining to be solved. Recently, the diagnosis and treatment of spinal stenosis have been facilitated due to introduction of computerized tomographic scanning apparatus. During the period of 3 years, from May 1979 to March 1982, we experienced 40 cases of spinal stenosis at Han Gang Sacred Heart Hospital and Gang Nam Sacred Heart Hospital. In study of this 40 cases clinical and radiological evaluation were made and obtained following result (25 cases of which were operated on). 1. The most common type was degenerative one (50%) 2. There were 16 males and 24 females (4:5) 3. The age distribution showed a peak incidence is the third decade (25%) 4. The most common chief complaint on admission was ill localized chronic sciatica (50%) 5. Decompressive surgery was carried on 25 cases such as; Laminectomy only (8%), Posterolateral fusion (20%), Both Laniinectomy and posterolateral fusion (72%) 6. The longest follow-up was 3 years and the shortest one was 4 months and the average was one year and four months. The outcome of follow-up were; excellent (52%), good (40%), fair (8%), poor (0%).
Age Distribution ; Back Pain ; Diagnosis ; Female ; Follow-Up Studies ; Heart ; Humans ; Incidence ; Laminectomy ; Male ; Sciatica ; Spinal Canal ; Spinal Stenosis

No abstract available.
Humans ; Teicoplanin*

In 1965, Melzack and Well proposed the gate-control theory which is based on modern neurophysiological principles. Its clinical application in western medicine remains in the area of pain control to relieve pain in certain diseases such as in the neck, scapula, elbow, wrist, knee, ankle joint pain, low back pain, facial palsy, headache, etc. Recent study, gradually developed in the western countries, has reported that the mechanism of action is by the method of the opiate receptor binding -sites and the release of intrinsic morphine like substances two related pentapeptides, 5HT (5-Hvdr oxyltriptamine), Na-glutamate, and by bradykinine, serotonine, histamine and prostaglandine E, etc. by peripheral nerve stimulation. It seems that the mechanism of stimulation involves neuropliysiological and neurohumoral inhibitory effects at the level of the spinal cord, brain stem (thalamus) and cortex. As yet it is not clear, but further study will improve the understanding of pain mechanisms in developed countries in the near future. Since 1976, the pain clinic in Hanyang University Hospital has used peripheral electrical acupuncture stimulation and found it to relieve pain which had not responded to various drugs and other methods. Here, the techinic and procedure of the treatment are described. The results for the forty-seven cases showed: marked improvement in 27 cases(57. 4%), improvement in 17 cases (36. 2%) and transient improvement in 3 cases (6. 4%).
Acupuncture ; Ankle Joint ; Bradykinin ; Brain Stem ; Developed Countries ; Elbow ; Facial Pain ; Headache ; Histamine ; Knee ; Low Back Pain ; Morphine ; Neck ; Pain Clinics ; Paralysis ; Peripheral Nerves* ; Receptors, Opioid ; Scapula ; Serotonin ; Spinal Cord ; Wrist

No abstract available.
Drug Therapy, Combination* ; Head and Neck Neoplasms* ; Head* ; Humans

No abstract available.
Umbilical Arteries*

Four cases of malignant hyperpyrexia were reported in Korea since 197I and three of these cases expired. We discuss here the four cases of malignant hyperpyrexia with clinical features and management, and the importance of early recorgnition and aggressive treatment of malignant hyperpyrexia are stressed.
Korea* ; Malignant Hyperthermia*

OBJECT: Social stigma and prejudice against schizophrenia hinder the prevention of the disease, early treatment and social rehabilitation. This stigma and the negative viewpoint against schizophrenia are enhanced by the mass media. This study investigated newspaper articles on psychosis, which strongly influence the public recognition of the illness. METHOD: The newspaper articles of Dong-A Ilbo and Chosun Ilbo from March 1998 to February 2000 were reviewed through a news-searching program in Chollian. The search words, which were regarded as psychotic illness, were Schizophrenia, Psychosis, Mental illness, and Mental derangement. A total of 326 articles were classified by category and analyzed quantitatively and qualitatively. The viewpoint of articles on psychosis consisted of these: (1) negative (direct or indirect) (2) neutral or positive (3) no specific viewpoint. RESULT: Of the 326 articles, the number with a negative description was 228 (69.9%), the number with a neutral or positive description was 43 (13.2%), and the number with no specific viewpoint was 55 (16.9%). The most frequent negative theme was psychotic patients are dangerous or violent or may commit a crime (n=118). Other negative themes were these: psychotic patients are bizarre or grotesque (n=27), psychotic patients can't function in society well(n=18), psychosis is incurable and families should bear great burden(n=16), psychosis is shameful (n=13) and psychotic patients should be institutionalized(n=6). There were also prejudices against the cause of the illness(n=18), the description of psychosis in degrading terms(n=22) and the negative description of psychiatric hospitalization(n=18) with the words such as institutionalization, imprisonment and put into etc. In the articles using the terms mental derangement or psychosis compared with mental illness, schizophrenia and in the articles describing psychotic patient compared with illness itself, the frequency of negative articles was high. Within each type of article, news, politics and culture articles more frequently had a negative description, while health articles less frequently had a negative description and most frequently had a neutral or positive description. CONCLUSION: There should be a program for monitoring newspapers for appropriate in-formation on psychosis. It might reduce social stigma and consequently help rehabilitation of psychotic patients. Also there should be endeavors to monitor other mass media and to develop a public education campaign through the mass media.
Crime ; Education ; Humans ; Institutionalization ; Mass Media ; Periodicals ; Politics ; Prejudice ; Psychotic Disorders* ; Rehabilitation ; Schizophrenia ; Shame ; Social Stigma

PURPOSE: To compare the accuracy of implantation by radiologic results between 3D Linker and navigation guided total knee arthroplasty. MATERIALS AND METHODS: Between February 2004 and April 2005, total knee arthroplasties were done in 25 knees with balanced gap-resection technique (group A) and 25 using kinematic navigation system(group B) by a single surgeon. All patients had standing long anteroposterior (AP) radiographs of the lower extremities and supine lateral radiographs of the knees at 6 weeks postoperatively. Mechanical axis deviation, alpha and beta, angles were measured on standing long leg AP views and alpha and beta angles on supine knee lateral views. Results were classified according to the deviation from the reference line and graded as excellent, good, and poor. The result was regarded as satisfactory when all five angles were excellent or good. RESULTS: The mean mechanical axis deviation was 1.11degrees in group A and 1.36degrees in group B and all were excellent in both groups. Regarding alpha.angles, 19 cases were excellent and, 6 good in group A and, 21 excellent and 4 good in group B. Regarding., angles, 22 cases were excellent and, 3 good in group A and, 23 excellent and 2 good in group B. Regarding.,, angles, 15 cases were excellent, 8 good and 2 poor in group A and, 15 excellent, 9 good, and 1 poor in group B. Regarding beta angles, 19 cases were excellent, 3 good and 3 poor in group A and, 23 excellent, and 2 poor in group B. There were no statistical differences between two groups in all five angles (p>0.05). An excellent implantation in all five angles was obtained in 28% in group A and 60% in group B (p<0.05). There were 80% of satisfactory cases in group A and 84% in group B with no statistical difference (p>0.05). CONCLUSION: Radiological results (mechanical axis and component angles) of total knee arthroplasty were satisfactory in 80% with balanced gap-resection technique and 84% with kinematic navigation system and showed no statistical difference.
Arthroplasty* ; Axis, Cervical Vertebra ; Humans ; Knee* ; Leg ; Lower Extremity