Lymphoma presenting with ulceration is not typical. Wereport a case of relapsed DLBCL in a 73-year-old manpresenting with a chronic non-healing leg ulcer. He hasunderlying varicose veins with recurrent venous ulcers. This patient was diagnosed to have DLBCL six years earlier when he presented with recurrent epistaxis originating from a left nasal cavity nodule. Complete resolution was achieved after eight cycles of R-CHOP and intrathecal methotrexate. For this current problem, this patient was treated with rituximab combined with chemotherapy which resulted in healing of the ulcer.