INTRODUCTIONTo describe the optic disc, visual field and ocular characteristics of a consecutive cohort of Asian patients with chronic primary angle-closure glaucoma (CPACG), and compare them with those having primary open-angle glaucoma (POAG).

METHODSIn a prospective comparative case series of new patients with POAG or CPACG in Singapore, all patients underwent visual acuity assessment, slit-lamp examination, tonometry, gonioscopy, refraction, Heidelberg Retina Tomograph (HRT) and Humphrey visual field (HVF) assessment.

RESULTS98 patients were enrolled (POAG n = 48; CPACG n = 50). CPACG patients were significantly older (66.5 ± 9.2 years vs. 64.1 ± 13.5 years; p = 0.027) and mostly female (p = 0.004). CPACG eyes had significantly higher intraocular pressure (26.9 ± 6.9 mmHg vs. 24.5 ± 3.3 mmHg; p = 0.03), shorter axial length (22.89 ± 0.97 mm vs. 24.26 ± 1.79 mm; p < 0.001) and shallower anterior chamber depth (2.60 ± 0.25 mm vs. 3.16 ± 0.48 mm; p < 0.001). HVF mean deviation or pattern standard deviation (PSD) did not differ significantly between POAG and CPACG eyes, but the latter had a lower PSD for a given mean deviation. HRT parameters between the two groups were not significantly different.

CONCLUSIONIn this study, CPACG eyes had significantly higher presenting intraocular pressure than POAG eyes, but there were no significant differences in optic disc topography. A majority of the patients in both groups had moderate field defects at the time of presentation, followed by severe and then mild defects. The field loss in CPACG eyes was more diffuse than that in POAG eyes.

Aged ; Female ; Glaucoma, Angle-Closure ; diagnosis ; pathology ; Glaucoma, Open-Angle ; diagnosis ; pathology ; Humans ; Intraocular Pressure ; Male ; Middle Aged ; Optic Disk ; pathology ; Prospective Studies ; Retina ; pathology ; Singapore ; Tomography ; Visual Field Tests ; Visual Fields

Introduction: Early environmental factors play a major role in shaping the health of an individual. Dietary preference and habits shaped by parental feeding practice during childhood are likely to persist into adulthood which further determines body weights status. This study aimed to determine the retrospective child feeding practices associated with obesity risk in young adults. Methods: This was a retrospective cross-sectional study with 176 university students in Kuala Lumpur. Data of maternal age, gestational age and feeding practices were collected retrospectively using Child Feeding Questionnaire (CFQ). Subject’s current socio-demographic data was collected and anthropometric measurements were taken using standard protocol. Results: Around 22% of the subjects were overweight/ obese. No significant association was found between child feeding practices with maternal age. A significant association (p<0.05) was found between pressure to eat with gestational age, in which parent with preterm (<37 weeks gestation) and full-term subjects were more likely to pressure their child to eat as compared to post-term subjects (>42 weeks gestation). Obesity risk in young adults was higher among parents who viewed themselves as overweight (aOR=2.783; CI=1.631-4.749) and who viewed their child as overweight from birth to primary school (aOR= 1.512; CI=1.080-2.116). Young adults that were pressured by their parents to eat during childhood were less likely to be obese (aOR=0.785; CI=0.621-0.992). Conclusion: Parental influences on child feeding practices were linked to obesity risk in young adulthood. Parent education on child feeding practices is needed to maintain healthy weight status of their child from young to later life.

Introduction: Delayed diagnosis of type 2 diabetes mellitus (T2D) increases the risk of presenting late with microvascular complications due to untreated long-standing hyperglycaemia. This study aimed to determine the prevalence of microvascular complications in newly diagnosed T2D patients in primary healthcare clinics. Methods: This was a cross-sectional study carried out in three government primary healthcare clinics in the state of Selangor, Malaysia. Malaysian aged 18 years and above with newly diagnosed T2D (≤ 6 months of diagnosis) were invited to participate in the study. Data collected included the sociodemographic characteristic and the clinical profile (weight, height, waist circumference, blood pressure, lipid, glycaemic, urine albumin, microalbuminuria and renal profile). The assessment of nephropathy, peripheral neuropathy and retinopathy were performed using standard protocol. Multivariate logistic regression analysis was used to identify the significant factors that contribute to the presence of microvascular complications. Results: A total of 162 newly diagnosed patients were recruited. The majority was women (64%). The mean age was 51 (SD 11) years. About one-third of the patients (27.7%) had developed at least one microvascular complication. Nephropathy was the commonest microvascular complication (19.2%), followed by peripheral neuropathy (8.6%) and retinopathy (6.5%). Poor glycaemic control was found to be a significant factor contributing to the presence of microvascular complications (OR 5.8, 95%CI:1.466, 23.288). Conclusion: There is a high prevalence of microvascular complications among the newly diagnosed T2D. There is a need to develop appropriate strategies to increase the awareness and early detection of T2D.