No abstract available.
Paranasal Sinuses*

No abstract available.
Decompression* ; Facial Nerve* ; Melkersson-Rosenthal Syndrome*

No abstract available.
Typhoid Fever*

Cardiovascular changes induced by a variety of physiological, surgical or emotional stresses are associated with increased sympathetic nervous system activtity. Sympathetic stimulation lowers the ventricular resistance in patients with ischemic heart disease. Thus sympathoadrenal aetivation may play role in sudden cardiac death. We measured the catecholamine levels just before and after fiberoptic gastroscopy, The results were as follows: 1) Though there was no statistical significance, plama catecholamine levels tends to increase during and after fiberoptic gastroscopy. 2) Significant changes in mean blood pressure did not occur during and after fiberoptic gastroscopy. 3) Before fiberoptic gastroscopy, norepinephrine level of three hypertensive patients were lower than the levels of studied patients, But during and after fiberoptic gastroacopy, norepinephrine level increased by 3 times. 4) The highest norepinephrine level was 847 pg/ml and epinephrine level was 110 pg/ml. Though sympathetic response was enhanced by fiberoptic gastroscopy, norepinephrine level did not increase up to the level shown in myocardial infarction or severe exercise.
Blood Pressure ; Death, Sudden, Cardiac ; Epinephrine ; Gastroscopy* ; Humans ; Myocardial Infarction ; Myocardial Ischemia ; Norepinephrine ; Stress, Psychological ; Sympathetic Nervous System

BACKGROUND: Bupivacaine is a potent, and commonly used, long acting local anesthetic. If accidentally injected into the systemic circulation, bupivacaine can cause lethal dysrhythmias and circulatory collapse. Attempts to treat bupivacaine induced cardiac toxicity have been varied and controversial, and they have not been very successful. The aim of this study was to investigate the electrophysiologic effects of bupivacaine in Purkinje fibers. METHODS: Effects of bupivacaine on the membrane potential were studied in 12 isolated canine Purkinje fibers. Purkinje fibers from ventricle were dissected and mounted in a tissue chamber perfused with Tyrode's solution. Transmembrane potentials recorded through glass microelectrodes filled with 3M KCI in the beating or quiescent Purkinje fibers during infusions of bupivacaine at concentratons of 3*10/-7M,10/-6M, 3*10/-6M,10/-5M, and 3*10/-5M. RESULTS: Bupivacaine reduced action potential druation in a dose-dependent manner. Bupivacaine produced a decrease in intracelullar sodium ion activity in driven(1Hz) and quiescent canine Purkinje fibers. Bupivacaine-induced hyperpolarizaton of diastolic membrane potential in quiescent Purkinje fibers was dose dependent, and the hyperpolarization by bupivacaine was attenuated by depolarization induced by high potassium extracellular concentration in part. CONCLUSIONS: These results suggest that bupivacaine decreases the fast inward sodium current, and inhibits pacemaker current in canine Purkinje fibers.
Action Potentials ; Bupivacaine* ; Glass ; Membrane Potentials* ; Membranes* ; Microelectrodes ; Potassium ; Purkinje Fibers ; Shock ; Sodium ; Sodium Channels

BACKGROUND: The effects of a newly synthesized potassium channel opener, KR-30816((-)(nitro-2-hydroxymethyl-2-methy-2H-1-benzopyran-4-y1)pyridine oxide) on the action potential of papillary muscles of guinea pigs and the ATP-sensitive potassium channel current(IKATP) of single ventricular muscle cells of rats were examined to make clear its action mechanism of the KATPchannel. METHODS: We used the conventional microelectrode and the excised inside-out patch configuration. RESULTS: KR-30816 caused a shortening of the action potential duration in dose-dependent manner, which was inhibited by glibenclamide(3microM). Before run-down of the K+channel, KR-30816 activated the cardiac ATP-sensitive K+ channel only in the presence of ATP and shifted the dose-response relation curve between [ATP]i and the channel activity to the right in parallel. After run-down of the KATP channel, KR-30816 did not after the channel opening either in the absence or in the presence of UDP. CONCLUSION: These results suggest that KR-30816 antagonizes the inhibitory effect of ATP on the KATPchannel in a competitive manner, thereby enhancing the channel openings.
Action Potentials ; Adenosine Triphosphate ; Animals ; Guinea Pigs ; Heart ; Microelectrodes ; Muscle Cells ; Papillary Muscles ; Potassium Channels* ; Potassium* ; Rats ; Uridine Diphosphate

Glycogen-rich clear cell carcinoma of the breast is very rare(l -3% of breast cancer). It is defined as a tumor composed of more than 50% of optically clear, neoplastic cells, characterized by centrally located nuclei and abundant cytoplasm, being positive for periodic acid Schiff(PAS) and negative for periodic acid Schiff after diastase(D-PAS) treatment. In the absence of intraductal or in situ lobular carcinoma component, metastatic clear cell carcinomas of other organs should be considered as diagnostic possibilities. We report a case of glycogen-rich clear cell carcinoma arisen in a 62-year-old woman. The tumor revealed both solid and papillary pattern with intraductal component. The neoplastic cells had clear cytoplasm, which were PAS positive, D-PAS negative, mucicarmine negative and oil red 0 negative. More than 90% of tumor cells exhibited moderate staining for anti-estrogen receptor monoclonal antibody. Flow cytometric DNA analysis revealed diploid DNA content.
Female ; Humans ; Neoplasm Metastasis ; Breast Neoplasms

OBJECTIVE: The aim of this study is to evaluate the role of tumor suppressor genes, p53 and Rb gene, as well as apoptosis in the carcinogenesis of ovarian epithelial tumors. And the value of these factors as prognostic markers to tell the transformation of borderline tumors to overt carcinomas is also studied. METHOD: Thirty cases of ovarian epithelial benign and borderline tumors and invasive carcinoma were used and the expression of the p53 protein and Rb gene protein were evaluated by immunohistochemical method. The apoptosis was evaluated by TUNNEL method. RESULTS: Positive rate of p53 expression in benign, borderline and invasive tumors were 0, 28, and 94 %, respectively. And also, p53 was highly expressed in chemoresistant cases (2/3), in residual tumor (4/5) and in recurred cancer (2/2). Rb protein was partly lost in the borderline tumors, but the rate of Rb protein loss in both borderline tumors and invasive carcinomas were similar. Apoptosis were more active in overt carcinomas than in borderline and benign tumors. In borderline tumors, p53 protein was expressed as 28.6% positivity, and apoptosis was expressed as 28.6% negativity, which showed indirectly that there was apoptosis induction effect of p53. In ten cases of invasive carcinomas showing highly expressed p53, apoptosis revealed all positive reaction except 2 cases, and Rb protein revealed variously. This result supported the apoptosis imduction effect of p53, but it was difficult to find the association of expression degree between the two tumor supressor genes CONCLUSION: In conclusion, the values of p53 is a discriminating factor of malignancy from benign and the expression of p53 is related with clinical aggressivity such as recurrence and residual cancers. Apoptosis are more active in overt carcinoma than in benign & borderline tumor, and in borderline tumor the expression of p53 is related to apoptosis induction which results to carcinomatous change.
Apoptosis* ; Carcinogenesis ; Genes, Retinoblastoma* ; Genes, Tumor Suppressor ; Neoplasm, Residual ; Recurrence ; Retinoblastoma Protein

Recently the scrotal diseases have been tended toward increment and take a important share in urologic disease entities. The reasons of them are thought for early reconstruction of the scrotal disease, increase of the diseases that need catheter indwelling and inclination of the scrotal injury by accident. Also up-to-date mass vasectomy have been performed for family planning, the scrotal complications have been increased. So authors report a clinical observation was made on 171 cases with scrotal disease who had been admitted to Department of Urology. E.W.U.H., Seoul, Korea, during the period from Apr. 1, 1976 through Mar. 1, 1981. The results were as follows; 1. Among 1025 cases of in-patients for past 5 years, 171 cases belong to scrotal disease giving a rate of 16.7%. 2. The most common population was 1-10 years of age giving a rate of 31.5%. 3. The most common disease was hydrocele giving a rate of 29.2%. The cryptorchism was 21%, epididymitis 15.8%, vasectomy complication 9.9%, scrotal injury 5%, sterility 4.7% and others 14.3%. 4. Of 171 cases, operation was performed in 152 cases (88.9%). 5. Most common operation was hydrocelectomy (27%), orchiopexy (19.1%), epididymectomy (9.9%) and incision and drainage (7.3%) in order.
Catheters ; Cryptorchidism ; Drainage ; Epididymitis ; Family Planning Services ; Infertility ; Korea ; Male ; Orchiopexy ; Scrotum ; Seoul ; Urologic Diseases ; Urology ; Vasectomy

Advances in gray scale ultrasonography have increased the usefulness of their modality in the clinical diagnostic method. Major improvements in the image resolution have greatly increased the diagnostic value of renal ultrasonography. The non-invasive and safe nature of ultrasound makes this technique ideal for accurate and quick evaluation. It has been well known facts that it is very difficult to obtain precise size, shape parenchymal thickness of the kidneys by conventional radiological techniques such as retrograde pyelography, antegrade percutaneous pyelography or arteriography and also the techniques are invasive to patients comparatively. Because of its simplicity, innocuousness and accurateness, diagnostic ultrasound is quite useful in the evaluation of functionally inactive kidney and should precede or be substitute for other aggressive technique. In those kidneys which remain unseen even after massive dose of dye, the ultrasound scan should be used before retrograde ureteral catheterization is undertaken. The author measured the size of kidney longitudinally, transversely and in thickness by ultrasonogram and compared with that of excretory urogram in 60 normal healthy persons and 32 cases of hydronephrosis. The results were obtained as follows: 1. The length of right kidney on ultrasonogram (11.4+/-0.55 cm) was smaller than on excretory urogram (12.2+/-0.45 cm) and the difference was 0.8 cm (t value: 2.21, p<0.02), and the length of left kidney on ultrasonogram (11.9+/-0.42 cm) was smaller than on excretory urogram (12.6+/-0.78 cm) and the difference was 0.7 cm (t value: 2.43. p<0.02). The width of right kidney on ultrasonogram (5.4+/-0.57 cm) was smaller than on excretory urogram (6.3+/-0.61 cm) and the difference was 0.9 cm (t value: 1.75, p<0.1) and the width of left kidney on ultrasonogram (5.6+/-0.58 cm) was smaller than on excretory urogram (6.3+/-0.49 cm) and the difference was 0.7 cm (t value: 1.82, p<0.1). The parenchymal depth of right kidney on ultrasonogram (2.2+/-0.48 cm) was larger than on excretory urogram (2.1+/-0.56 cm) and the difference was 0.1 cm (t value: 2.89, p<0.001), and the parenchymal depth of left kidney on ultrasonogram (2.1+/-0.54 cm) was alike on excretory urogram (2.1+/-0.57 cm) and there was no difference (t value: 2.31, p<0.05). 2. Among the 32 cases of hydronephrosis. 17 cases of hydronephrosis could be diagnosed by excretory urogram. In mild hydronephrosis, the length of kidney on ultrasonogram (12.2+/-0.56 cm) was smaller than on excretory urogram (12.8+/-0.46 cm) and the difference was 0.6 cm, the width of kidney on ultrasonogram (6.1+/-0.27 cm) was smaller than on excretory urogram (6.4+/-0.38 cm) and the difference was 0.3 cm, and the parenchymal depth of kidney on ultrasonogram (2.1+/-0.34 cm) was alike on excretory urogram (2.1+/-0.49 cm) and there no difference. In moderate hydronephrosis, the length of kidney on ultrasonogram(13.5+/-0.47 cm) was smaller than on excretory urogram(14.2+/-0.67 cm)and the difference was 0.7cm, the width of kidneys no ultrasonogram(7.2+/-0.58 cm) was smaller than on excretory urogram(7.8+/-0.73 cm) and the difference was 0.6cm, and the parenchymal depth of kidney on ultrasonogram(1.2+/-0.57 cm) was smaller than on excretory urogram(1.47+/-0.27 cm)and the difference was 0.2 cm. In severe hydronephrosis, the length of kidney on ultrasonogram(15.7+/-0.39 cm)was smaller than on excretory urogram(16.6+/-0.53 cm) and the difference was 0.9cm, the width of kidney on ultrasonogram(8.8+/-0.46 cm) was smaller than on excretory urogram(9.5+/-0.48 cm)and the difference was 0.7 cm, and the parenchymal depth of kidney on ultrasonogram was 0.7+/-0.27 cm but could not be measured on excretory urogram. 3. Among 32 cases of hydronephrosis,15 cases of hydronephrosis were non-visualized kidney on excretory urogram. On them, the renal sized and parenchymal depth were measured accurately by ultrasonography. By reviewing the above results, the ultrasonography of kidney is useful in measurement of kidney size and can be substitute for invasive uroradiological methods in evaluation of patients with hydronephrosis.
Adult* ; Angiography ; Humans ; Hydronephrosis* ; Kidney* ; Ultrasonography* ; Urinary Catheterization ; Urinary Catheters ; Urography