Students of alopecia areata (AA) face confusion in the understanding of the follicular status of the lesion. This confusion partly is related to varing histopathological descriptions given by different authors. In an attempt to clarify these varing descriptions, we made our own observations on 45 scalp biopsies from the patients with AA. The lesions were devided into four groups by the duration of the alopecia. The results were as in the following. Initial stage (within 2 weeks after the onset, 5 cases) showed mostly the catagen stage of terminal hair follicles and pigmentary incontinence in all cases. Only 2 cases (40%) showed significant cellular infiltrate. Progressive stage (between 2 weeks and several months after onset, 11 cases) showed catagen follicles of terminal hair with the development of miniature follicles among them. Pigmentary incontinence and inflammatory cell infiltrate were seen in 9 cases (82%) and 8 cases (73%) respectively. In established stage (26 cases), miniature follicles were predominant with pigmentary incontinence (73%: 19 cases) and cellular infiltrate (69%: 18 cases). In recovery stage, there were normal anagen follicles with absent or decreased inflammatory cells and pigmentary incontinence. A proposal that hair follicles better be designated not only with their stages but also with their types is presented.
Alopecia Areata* ; Alopecia* ; Biopsy ; Hair ; Hair Follicle ; Humans ; Scalp

No abstract available.
Temporomandibular Joint*

No abstract available.
Adolescent* ; Epidemiologic Studies* ; Humans ; Temporomandibular Joint*

No abstract available.
Hair* ; Iron* ; Scalp*

No abstract available.
Addison Disease*

No abstract available.
Temporomandibular Joint*

Objective To sdudy the expression of p53 and nm23-H1 proteins and their clinical significance in nasopharyngeal carcinoma.Methods The expression of p53 and nm23-H1 proteins were detected by immunohistochemistry method in 40 cases with nasopharyngeal carcinoma and 22 cases with chronic inflammation of nasopharyngeal mucosa tissues.Results Positive rates of p53 and nm23-H1 in chronic nasopharyngitis group were 1.0 ％,27.2 ％,and in the NPC group were 92.5 ％,55.0 ％.There were 9 cases with the positive expression of p53 in 22 cases of nasopharyngeal carcinoma tissues with the positive expression of nm23-H1 (40.9 ％).There were 17 cases with the positive expression of p53 in 18 cases with the negative expression of nm23-H1 (94.4 ％).The expression of p53 and nm23-H1 proteins in nasopharyngeal carcinoma were much higher than that in chronic inflammation of nasopharyngeal mucosa tissues.The expression of p53 protein in nasopharyngeal carcinoma with metastatic lymph node was higher than that in nasopharyngeal carcinoma without metastatic lymph node,but nm23-H1 protein lower.The expression of p53 protein was positively correlated with the metastasis,clinnical staging and pathological classification but not correlated with T classification of nasopharyngeal carcinoma.The expression of nm23-H1 protein was negative correlation with the metastasis and clinical staging of nasopharyngeal carcinoma.Conclusion p53 and nm23-H1 play important coordinated regulation roles in the carcinogenesis,development and metastasis of nasopharyngeal carcinoma and will probably become the key biological marks in the judging and evaluating prognosis of nasopharyngeal carcinoma.

BACKGROUND: Total intravenous anesthesia with propofol can cause respiratory depression and apnea especially during induction of anesthesia. To study the possibility of reversal of respiratory depression during anesthesia with propofol, pretreated with nabuphine or not, the respiratory effects of doxapram to spontaneously ventilating patients were investigated. METHODS: Patients were divided into 4 groups - saline-propofol-saline group (SPS), saline-propofol- doxapram group (SPD), nalbuphine-propofol-saline group (NPS), and nalbuphine-propofol-doxapram group (NPD). After saline or nalbuphine pretreatment, anesthesia was induced with propofol and then doxapram or saline was intravenously injected. Apneic time interval, blood pressure, heart rate, respiratory rate, minute ventilation, end tidal CO2 partial pressure and oxygen saturation were measured in every minutes during induction of anesthesia. Percent changes of each values were compared. RESULTS: There is no differences in apneic time intervals in each groups. The percent change of first minute ventilation in SPD group after doxapram injection unchanged significantly compared with those depressions of SPS, NPS and NPD group (p<0.05). Respiratory rates increased in SPD and SPS groups after laryngeal mask insertion. There is no differences in minute ventilation, respiratory rate and end-tidal CO2 concentration between nalbuphine pretreated groups regardless of doxapram injection. CONCLUSIONS: Doxapram has effect in increasing minute ventilation after propofol induction within first few minutes, but it cannot reverse respiratory depression during propofol induction pretreated with nalbuphine.
Anesthesia ; Anesthesia, Intravenous* ; Apnea ; Blood Pressure ; Depression ; Doxapram* ; Heart Rate ; Humans ; Laryngeal Masks ; Nalbuphine* ; Oxygen ; Partial Pressure ; Propofol* ; Respiratory Insufficiency ; Respiratory Rate ; Ventilation

No abstract available.
Humans ; Temporomandibular Joint Disorders* ; Temporomandibular Joint*