1.Spinal Epidural Lipomatosis: Report of Four Cases.
Tae Wan KIM ; Yong Suk HUH ; Moon Pyo CHI ; Jae O KIM ; Jung Chul KIM
Journal of Korean Neurosurgical Society 2000;29(11):1527-1532
No abstract available.
Lipomatosis*
2.Prospective study of Efficacy of Colonic Cleansing and Patients Acceptance according to the Time of Colonoscopy.
Tae Young LEE ; Jae Kyeong LEE ; Wan Su KIM ; Cheon Hwan KIM ; Young Lan SEONG ; Jae Seuk PARK ; Mi Kyeong PARK ; San Gyun NA ; Kap Do HUH
Korean Journal of Gastrointestinal Endoscopy 1996;16(4):575-584
Because most of modern peoples are busy with many their task according to specialization and complexity of society, it is impportant to determine optimal and comfortable time of colonoscopy. So this study was designed to compare efficacy of colonic cleansing and patient acceptance according to the time of colonoseopy. Among 140 peoples who underwent colonoscoyy in Busan St. Benedict Hospital between March 1995 to August 1995, two groups of 70 peoples were randomly assigned to undergo colonoscopy either at A.M. or ~P.M. The results were as follows: 1) In view of efficacy rate of colonic cleansing, the group at P.M, was superior to the group at A.M.. 2) In view of patients acceptance and side effects, the group at P.M. showed better acceptance and less side effects than the group at A.M.. In conclusion, this study showed that the colonoscopy at P.M. is better than at A.M., especially when patient is poor systemic condition or low acceptance to colonoscopic cleansing preparation. However, it may be also acceptable undergoing colonoscopy at A.M. if patient condition is good and patient is busy with his task.
Busan
;
Colon*
;
Colonoscopy*
;
Humans
;
Prospective Studies*
3.Natural History of Unruptured Intracranial Aneurysms : A Retrospective Single Center Analysis.
Hyoung Soo BYOUN ; Won HUH ; Chang Wan OH ; Jae Seung BANG ; Gyojun HWANG ; O Ki KWON
Journal of Korean Neurosurgical Society 2016;59(1):11-16
OBJECTIVE: We conducted a retrospective cohort study to elucidate the natural course of unruptured intracranial aneurysms (UIAs) at a single institution. METHODS: Data from patients diagnosed with UIA from March 2000 to May 2008 at our hospital were subjected to a retrospective analysis. The cumulative and annual aneurysm rupture rates were calculated. Additionally, risk factors associated with aneurysmal rupture were identified. RESULTS: A total of 1339 aneurysms in 1006 patients met the inclusion criteria. During the follow-up period, 685 aneurysms were treated before rupture via either an open surgical or endovascular procedure. Six hundred fifty-four UIAs were identified and not repaired during the follow-up period. The mean UIA size was 4.5+/-3.2 mm, and 86.5% of the total UIAs had a largest dimension <7 mm. Among these UIAs, 18 ruptured at a median of 1.6 years (range : 27 days to 9.8 years) after day 0. The annual rupture risk during a 9-year follow-up was 1.00%. A multivariate Cox proportional hazards analysis revealed that the aneurysm size and a history of subarachnoid hemorrhage (SAH) were statistically significant risk factors for rupture. For an aneurysms smaller than 7 mm in the absence of a history of SAH, the annual rupture risk was 0.79%. CONCLUSION: In our study, the annual rupture risk for UIAs smaller than 7 mm in the absence of a history of SAH was higher than that of Western populations but similar to that of the Japanese population.
Aneurysm
;
Asian Continental Ancestry Group
;
Cohort Studies
;
Endovascular Procedures
;
Follow-Up Studies
;
Humans
;
Intracranial Aneurysm*
;
Natural History*
;
Retrospective Studies*
;
Risk Factors
;
Rupture
;
Subarachnoid Hemorrhage
4.Delayed Vasospasm after Aneurysmal Subarachnoid Hemorrhage in Behcet Syndrome.
Jun Hak KIM ; Si Un LEE ; Choonwoong HUH ; Chang Wan OH ; Jae Seung BANG ; Tackeun KIM
Journal of Cerebrovascular and Endovascular Neurosurgery 2016;18(1):27-31
A man visited the emergency room with a headache. Brain computed tomography showed aneurysmal subarachnoid hemorrhage (SAH) and multiple aneurysms. After aneurysm clipping surgery, the patient was discharged. After 5 days, he was admitted to the hospital with skin ulceration and was diagnosed with Behcet syndrome. An angiogram taken 7 weeks after aneurysmal SAH showed intracranial vasospasm. Because inflammation in Behcet syndrome may aggravate intracranial vasospasm, intracranial vasospasm after aneurysmal SAH in Behcet syndrome should be monitored for longer compared to general aneurysmal SAH.
Aneurysm*
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Behcet Syndrome*
;
Brain
;
Emergency Service, Hospital
;
Headache
;
Humans
;
Inflammation
;
Skin Ulcer
;
Subarachnoid Hemorrhage*
;
Vasospasm, Intracranial
5.Effect of two-phase fabrication method for the optimum fit of light-polymerized record bases.
Jung Bo HUH ; Min Goo KANG ; Sang Wan SHIN ; Jae Jun RYU
The Journal of Advanced Prosthodontics 2010;2(3):102-105
PURPOSE: The aims of this study were to suggest a method of fabrication of the record base using a light-polymerized resin by applying the two-phase fabrication method for the improvement of the fit of the record base and to compare the degree of fit according to the separation site. MATERIAL AND METHODS: In the edentulous cast of maxilla, four test groups were considered. In the first, second, third, and fourth test groups (n = 12 in each group) the separation was done at 0, 5, 10, and 15 mm, respectively below the alveolar crest along the palatal plane. For the control group, the record base was made without separating the two sections. The light-body silicone material was injected into the fitting surface of the record base. It was then placed onto the cast and finger pressure was applied to stabilize it in a seated position followed by immediate placement onto the universal test device. Finally, the mass of the impression material was measured after it was removed. ANOVA was performed using the SAS program. For the post-hoc test, the Wilcoxon Rank-Sum test and the Tukey-Kramer HSD test were performed (alpha = 0.05). RESULTS: The control group and Group 3, 4 showed significant differences. The Group 3 and 4 showed significantly smaller inside gaps than the control group which was not made with the two-phase fabrication method. CONCLUSION: The two-stage polymerized technique can improve the fit of the denture base particularly when the separation was made at 10 to 15 mm from the alveolar crest.
Collodion
;
Denture Bases
;
Fingers
;
Maxilla
;
Phenothiazines
;
Polymers
;
Silicones
6.Glycated Albumin Is a More Useful Glycation Index than HbA1c for Reflecting Renal Tubulopathy in Subjects with Early Diabetic Kidney Disease.
Ji Hye HUH ; Minyoung LEE ; So Young PARK ; Jae Hyeon KIM ; Byung Wan LEE
Diabetes & Metabolism Journal 2018;42(3):215-223
BACKGROUND: The aim of this study was to investigate which glycemic parameters better reflect urinary N-acetyl-β-D-glucosaminidase (uNAG) abnormality, a marker for renal tubulopathy, in subjects with type 2 diabetes mellitus (T2DM) subjects with normoalbuminuria and a normal estimated glomerular filtration rate (eGFR). METHODS: We classified 1,061 participants with T2DM into two groups according to uNAG level—normal vs. high (>5.8 U/g creatinine)—and measured their biochemical parameters. RESULTS: Subjects with high uNAG level had significantly higher levels of fasting and stimulated glucose, glycated albumin (GA), and glycosylated hemoglobin (HbA1c) and lower levels of homeostasis model assessment of β-cell compared with subjects with normal uNAG level. Multiple linear regression analyses showed that uNAG was significantly associated with GA (standardized β coefficient [β]=0.213, P=0.016), but not with HbA1c (β=−0.137, P=0.096) or stimulated glucose (β=0.095, P=0.140) after adjusting confounding factors. In receiver operating characteristic analysis, the value of the area under the curve (AUC) for renal tubular injury of GA was significantly higher (AUC=0.634; 95% confidence interval [CI], 0.646 to 0.899) than those for HbA1c (AUC=0.598; 95% CI, 0.553 to 0.640), stimulated glucose (AUC=0.594; 95% CI, 0.552 to 0.636), or fasting glucose (AUC=0.558; 95% CI, 0.515 to 0.600). The optimal GA cutoff point for renal tubular damage was 17.55% (sensitivity 59%, specificity 62%). CONCLUSION: GA is a more useful glycation index than HbA1c for reflecting renal tubulopathy in subjects with T2DM with normoalbuminuria and normal eGFR.
Diabetes Mellitus, Type 2
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Diabetic Nephropathies*
;
Fasting
;
Glomerular Filtration Rate
;
Glucose
;
Hemoglobin A, Glycosylated
;
Homeostasis
;
Kidney Tubules
;
Linear Models
;
ROC Curve
;
Sensitivity and Specificity
7.A Case of Undifferenciated Large Cell Carcinoma of Lung Associated with Neurofibromatosis.
Jeong Rye HYUN ; Jae Sam KIM ; Nak Hyun SEOK ; Seok Kie PAEK ; Wan Jae HUH ; Chai Ho IM ; Hai Ju YANG ; Kye Young KIM
Korean Journal of Medicine 1997;52(2):257-262
Neurofibromatosis also referred to as von Recklinghausen`s disease, is an autosomal dominant disease, which is characterized by cutaneous neurofibromas, cafe-au-lait spot, and axillary freckles. Although neruofibromatosis is a congenital disorder, the pulmonary manifestation become evident in adulthood. Approximately 15percent of patients with cutaneous lesions have intrathoracic neurofibromas. In some patients with neurofibromatosis, the lungs are the seat of interstitial fibrosis, leiomyoma, and bullous lesion, meningocele or less commonly lung cancer. The association of neurofibromatosis and lung cancer is rare, A 47-year-old man, who was a heavy smoker, was admitted to our hospital because of hemoptysis. Since cafe-au-lait sopts, diffuse pigmentation and multiple neurofibromatosis were observed on the skin, he was considered to have von Recklinghausen`s disease. Chest X-ray film showd extensive hazy density affecting all of his lung field, and minimal peribronchial infiltratin in his left lower lung field. Chest CT showed that near total consolidative lesions were present of right middle lobe. Also, some patchy infiltration were present in his right lower lobe and some of left lower lobe. Histoathological examination of the percutaneous lung biopsy specimen demonstrated that he had undifferentiated large cell carcinoma. The Authors have experienced a case of neurofibromatosis combined with undifferntiated large cell carcinoma. A brief review of related literature was conducted.
Biopsy
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Blister
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Cafe-au-Lait Spots
;
Carcinoma, Large Cell*
;
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
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Fibrosis
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Hemoptysis
;
Humans
;
Leiomyoma
;
Lung Neoplasms
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Lung*
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Melanosis
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Meningocele
;
Middle Aged
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Neurofibroma
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Neurofibromatoses*
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Pigmentation
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Skin
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Thorax
;
Tomography, X-Ray Computed
;
X-Ray Film
8.Effect of rhPMP-2 coated implants on alveolar ridge augmentation in dogs.
Chan Kyung PARK ; Jong Eun KIM ; Ju Hee SHIN ; Jae Jun RYU ; Jung Bo HUH ; Sang Wan SHIN
The Journal of Korean Academy of Prosthodontics 2010;48(3):202-208
PURPOSE: This study was aimed to evaluate the effect of rhPMP-2 coated implants on alveolar ridge augmentation in dogs. Material and METHODS: Six Beagle dogs were used in this study. Six 8.0 mm long anodized surface titanium implants were placed 5 mm into the mandibular alveolar ridge following 6 month of healing period after extraction. Each animal received three implants coated with rhBMP-2 and three uncoated control implants using the randomized split-mouth design. Radiographic examinations were undertaken i mmediately at implant placement (baseline), at weeks 4 and 8 after implant placement. The amount of bone augmentation was evaluated by measuring the distance from the uppermost point of the coverscrew to the marginal bone. Implant Stability Quotient (ISQ) values were measured i mmediately at implant placement and 8 weeks after implant placement. For the statistical analysis, Man-Whitney ranksum test and Wilcoxon signed rank test of SPSS 12.0 software were used (P = .05). RESULTS: The BMP group exhibited radiographic vertical bone augmentation about 0.6 +/- 0.7 mm at 8 weeks later while controls showed bone loss about 0.4 +/- 0.6 mm. There was significant difference among the rhBMP-2 group and controls in bone level change (P < .05). The ISQ values were significantly higher in the BMP-2 group than the control group at 8 weeks later (P < .05), while there was no significant difference at surgery. CONCLUSION: Within the limitation of this study, the rhBMP-2 coated on anodized implant could stimulate vertical alveolar bone augmentation, which may increase implant stability significantly on completely healed alveolar ridge.
Alveolar Process
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Alveolar Ridge Augmentation
;
Animals
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Dogs
;
Osseointegration
;
Titanium
9.Regulation of glutamate level in rat brain through activation of glutamate dehydrogenase by Corydalis ternata.
Kwan Ho LEE ; Jae Wan HUH ; Myung Min CHOI ; Seung Yong YOON ; Seung Ju YANG ; Hea Nam HONG ; Sung Woo CHO
Experimental & Molecular Medicine 2005;37(4):371-377
When treated with protopine and alkalized extracts of the tuber of Corydalis ternata for one year, significant decrease in glutamate level and increase in glutamate dehydrogenase (GDH) activity was observed in rat brains. The expression of GDH between the two groups remained unchanged as determined by Western and Northern blot analysis, suggesting a post-translational regulation of GDH activity in alkalized extracts treated rat brains. The stimulatory effects of alkalized extracts and protopine on the GDH activity was further examined in vitro with two types of human GDH isozymes, hGDH1 (house-keeping GDH) and hGDH2 (nerve-specific GDH). Alkalized extracts and protopine activated the human GDH isozymes up to 4.8-fold. hGDH2 (nervespecific GDH) was more sensitively affected by 1 mM ADP than hGDH1 (house-keeping GDH) on the activation by alkalized extracts. Studies with cassette mutagenesis at ADP-binding site showed that hGDH2 was more sensitively regulated by ADP than hGDH1 on the activation by Corydalis ternata. Our results suggest that prolonged exposure to Corydalis ternata may be one of the ways to regulate glutamate concentration in brain through the activation of GDH.
Animals
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Berberine Alkaloids/pharmacology
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Brain/*drug effects/enzymology
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Corydalis/*chemistry
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Enzyme Activation/drug effects
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Glutamate Dehydrogenase/genetics/*metabolism
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Glutamic Acid/*metabolism
;
Isoenzymes/genetics/metabolism
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Plant Extracts/pharmacology
;
RNA, Messenger/analysis/metabolism
;
Rats
;
Research Support, Non-U.S. Gov't
10.Risk assessment for clinical attachment loss of periodontal tissue in Korean adults.
Gun Bak RHEU ; Suk JI ; Jae Jun RYU ; Jung Bok LEE ; Chol SHIN ; Jeong Yol LEE ; Jung Bo HUH ; Sang Wan SHIN
The Journal of Advanced Prosthodontics 2011;3(1):25-32
PURPOSE: The purpose of this study was to assess the prevalence and extent of clinical attachment loss of periodontal tissue and to find out variables related to clinical attachment loss (CAL) in Korean adults older than 40 years of age. MATERIALS AND METHODS: Data were collected from 2,519 subjects who were part of a cohort study conducted in Ansan city by Korea University Medical School for Korean Genome project. Age, sex, smoking, drinking, fast glucose, blood pressure, obesity and total cholesterol levels were examined. The oral examination included probing pocket depth, gingival recession and CAL of Ramford's teeth. The severity of periodontitis was classified based on the mean value of CAL. The relationship between each risk factor and the severity of CAL was independently estimated using the chi-square test, the test or one-way ANOVA. Multiple regression analysis was used to determine the significance of each factor in the periodontal disease. RESULTS: The prevalences of clinical attachment between 1 and 3 mm, between 3 and < 5 mm, and > or = 5 mm were 80.27%, 16.75% and < 1%, respectively. Although the univariate analysis showed age, gender, smoking, fasting glucose, blood pressure and total cholesterol levels were significantly related to the severity of CAL, multiple regression analysis indicated that age (P < .0001), gender (P < .0001) and smoking (P < .05) were only significantly related. CONCLUSION: Older age, male gender and smoking were significant risk factor for the increase of CAL, and these may be useful indicators of periodontitis high-risk groups.
Adult
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Blood Glucose
;
Cholesterol
;
Cohort Studies
;
Diagnosis, Oral
;
Drinking
;
Fasting
;
Genome
;
Gingival Recession
;
Humans
;
Korea
;
Male
;
Obesity
;
Periodontal Attachment Loss
;
Periodontitis
;
Prevalence
;
Risk Assessment
;
Risk Factors
;
Schools, Medical
;
Smoke
;
Smoking
;
Tooth