1.Anterior Stabilisation of Sacroilliac Joint for Complex Pelvic Injuries
Wan Ismail Wan Faisham ; Amir Hussain Nawaz ; Johari Joehaimey ; Ahmad Yaacob Sallehuddin ; Zulmi Wan
Malaysian Journal of Medical Sciences 2009;16(3):49-53
Sacroilliac joint diasthesis from high energy trauma is always complicated with chronic pain and long term morbidity. Open anterior stabilisation with plate allow direct reduction and stabilisation with biomechanically advantages. Here we report on four cases of pelvic injury with sacroiliac joint disruption treated with anterior plate stabilisation through a surgical approach similar to that used for anterior ring fractures.
2.Antibacterial and biofilm inhibition activities of Melastoma malabathricum stem bark extract against Streptococcus mutants
Rohazila Mohamad Hanafiah ; Wan Syaidatul Aqma ; Wan Ahmad Yaacob ; Zulfahmi Said ; Nazlina Ibrahim
Malaysian Journal of Microbiology 2015;11(2):199-206
Aim: This study was to determine the antibacterial activity of Melastoma malabathricum stem bark acetone extract
(MMSBAE) against Streptococcus mutans.
Methodology and results: Antibacterial activity of the extract was determined by minimal inhibitory concentration
(MIC), minimal bactericidal concentration (MBC), biofilm formation, adherence inhibition, time kill studies and effect on S.
mutans membrane integrity. MIC and MBC values of MMSBAE were 1.25 and 5 mg/mL, respectively. Time kill studies
showed that reduction of colony forming unit in treated cells is 3 log10 after 10 h of treatment (p ˂ 0.05). The extracts
reduced 50% biofilm and adherence activity of S. mutans at 1.88 mg/mL. The effect on S. mutans membrane integrity
after exposure to MMSBAE for 90 and 120 min was determined by measuring leakage of cell content at 2 different
wavelengths of 260 nm and 280 nm. In leakage assay, the percentage of absorbance (260 nm) in treated cell material
showed 57% at 90 min and 60% at 120 min which is higher than negative control (<20%) but less than positive control
(100%). The percentage absorbance of treated cell material (280 nm) was 61% at 90 min and 63% at 120 min.
Identification of compound in MMSBAE was done by gas chromatography mass spectrometry (GCMS). Ten compounds
were identified in the MMSBAE with some of them important in antimicrobial activity such as ethyl ester, undecene, and
gamma sitosterol.
Conclusion, significance and impact of study: MMSBAE showed excellent bactericidal and antibacterial activities
against S. mutans. The antibacterial mode of action of MMSBAE is suggested to be the disruption of the S. mutans
membrane structure. The MMSBAE significantly inhibited biofilm and adherence activities of S. mutans in dose
dependent manner (p ˂ 0.05). MMSBAE has potential in the development of antibacterial agent with anti-biofilm and
anti-adherence activities.
3.Reporting Statistical Results in Medical Journals
Wan Nor Arifin ; Abdullah Sarimah ; Bachok Norsa’adah ; Yaacob Najib Majdi ; Ab Hamid Siti-Azrin ; Musa Kamarul Imran ; Abd Aziz Aniza ; Lin Naing
Malaysian Journal of Medical Sciences 2016;23(5):1-7
Statistical editors of the Malaysian Journal of Medical Sciences (MJMS) must go through
many submitted manuscripts, focusing on the statistical aspect of the manuscripts. However, the
editors notice myriad styles of reporting the statistical results, which are not standardised among
the authors. This could be due to the lack of clear written instructions on reporting statistics in the
guidelines for authors. The aim of this editorial is to briefly outline reporting methods for several
important and common statistical results. It will also address a number of common mistakes
made by the authors. The editorial will serve as a guideline for authors aiming to publish in the
MJMS as well as in other medical journals.
4.Individual and contextual factors associated with measles infection in Malaysia: a multilevel analysis
Mohd Rujhan Hadfi Mat DAUD ; Nor Azwany YAACOB ; Wan Nor ARIFIN ; Jamiatul Aida Md SANI ; Wan Abdul Hannan Wan IBADULLAH
Osong Public Health and Research Perspectives 2024;15(5):429-439
Despite effective vaccination strategies, measles remains a global public health challenge. The study explored individual and contextual factors associated with measles infection in Malaysia from 2018 to 2022, informing the development of targeted public health interventions. Methods: This cross-sectional study utilised data from the Ministry of Health, the Department of Statistics, and the Department of Environment Malaysia. Multilevel logistic regression analysis was employed to examine individual-level factors, including age, sex, ethnicity, nationality, contact history, travel history, and vaccination status. Concurrently, contextual factors were assessed, encompassing district-level determinants such as population density, median household income, urbanisation, the number of health and rural clinics, vaccination rates, fine particulate matter less than 2.5 μm (PM2.5) levels, relative humidity, and temperature, to determine their impact on measles infection risk. Results: Measles infection was significantly associated with various individual factors. These included age (adjusted odds ratio [aOR], 1.02; 95% confidence interval [CI], 1.02–1.03), ethnicity, non-Malaysian nationality (aOR, 34.53; 95% CI, 8.42– 141.51), prior contact with a measles case (aOR, 2.36; 95% CI, 2.07–2.69), travel history (aOR, 2.30; 95% CI, 1.13–4.70), and vaccination status (aOR, 0.76; 95% CI, 0.72–0.79). Among contextual factors, urbanisation (aOR, 1.56; 95% CI, 1.16– 2.10) and the number of clinics (aOR, 0.98; 95% CI, 0.97–0.99) were significant determinants. Conclusion: This multilevel logistic regression analysis illuminates the complexities of measles transmission, advocating public health interventions tailored to individual and contextual vulnerabilities. The findings highlight the need for a synergistic approach that combines vaccination campaigns, healthcare accessibility improvements, and socioeconomic interventions to effectively combat measles.
5.Individual and contextual factors associated with measles infection in Malaysia: a multilevel analysis
Mohd Rujhan Hadfi Mat DAUD ; Nor Azwany YAACOB ; Wan Nor ARIFIN ; Jamiatul Aida Md SANI ; Wan Abdul Hannan Wan IBADULLAH
Osong Public Health and Research Perspectives 2024;15(5):429-439
Despite effective vaccination strategies, measles remains a global public health challenge. The study explored individual and contextual factors associated with measles infection in Malaysia from 2018 to 2022, informing the development of targeted public health interventions. Methods: This cross-sectional study utilised data from the Ministry of Health, the Department of Statistics, and the Department of Environment Malaysia. Multilevel logistic regression analysis was employed to examine individual-level factors, including age, sex, ethnicity, nationality, contact history, travel history, and vaccination status. Concurrently, contextual factors were assessed, encompassing district-level determinants such as population density, median household income, urbanisation, the number of health and rural clinics, vaccination rates, fine particulate matter less than 2.5 μm (PM2.5) levels, relative humidity, and temperature, to determine their impact on measles infection risk. Results: Measles infection was significantly associated with various individual factors. These included age (adjusted odds ratio [aOR], 1.02; 95% confidence interval [CI], 1.02–1.03), ethnicity, non-Malaysian nationality (aOR, 34.53; 95% CI, 8.42– 141.51), prior contact with a measles case (aOR, 2.36; 95% CI, 2.07–2.69), travel history (aOR, 2.30; 95% CI, 1.13–4.70), and vaccination status (aOR, 0.76; 95% CI, 0.72–0.79). Among contextual factors, urbanisation (aOR, 1.56; 95% CI, 1.16– 2.10) and the number of clinics (aOR, 0.98; 95% CI, 0.97–0.99) were significant determinants. Conclusion: This multilevel logistic regression analysis illuminates the complexities of measles transmission, advocating public health interventions tailored to individual and contextual vulnerabilities. The findings highlight the need for a synergistic approach that combines vaccination campaigns, healthcare accessibility improvements, and socioeconomic interventions to effectively combat measles.
6.Individual and contextual factors associated with measles infection in Malaysia: a multilevel analysis
Mohd Rujhan Hadfi Mat DAUD ; Nor Azwany YAACOB ; Wan Nor ARIFIN ; Jamiatul Aida Md SANI ; Wan Abdul Hannan Wan IBADULLAH
Osong Public Health and Research Perspectives 2024;15(5):429-439
Despite effective vaccination strategies, measles remains a global public health challenge. The study explored individual and contextual factors associated with measles infection in Malaysia from 2018 to 2022, informing the development of targeted public health interventions. Methods: This cross-sectional study utilised data from the Ministry of Health, the Department of Statistics, and the Department of Environment Malaysia. Multilevel logistic regression analysis was employed to examine individual-level factors, including age, sex, ethnicity, nationality, contact history, travel history, and vaccination status. Concurrently, contextual factors were assessed, encompassing district-level determinants such as population density, median household income, urbanisation, the number of health and rural clinics, vaccination rates, fine particulate matter less than 2.5 μm (PM2.5) levels, relative humidity, and temperature, to determine their impact on measles infection risk. Results: Measles infection was significantly associated with various individual factors. These included age (adjusted odds ratio [aOR], 1.02; 95% confidence interval [CI], 1.02–1.03), ethnicity, non-Malaysian nationality (aOR, 34.53; 95% CI, 8.42– 141.51), prior contact with a measles case (aOR, 2.36; 95% CI, 2.07–2.69), travel history (aOR, 2.30; 95% CI, 1.13–4.70), and vaccination status (aOR, 0.76; 95% CI, 0.72–0.79). Among contextual factors, urbanisation (aOR, 1.56; 95% CI, 1.16– 2.10) and the number of clinics (aOR, 0.98; 95% CI, 0.97–0.99) were significant determinants. Conclusion: This multilevel logistic regression analysis illuminates the complexities of measles transmission, advocating public health interventions tailored to individual and contextual vulnerabilities. The findings highlight the need for a synergistic approach that combines vaccination campaigns, healthcare accessibility improvements, and socioeconomic interventions to effectively combat measles.
7.Individual and contextual factors associated with measles infection in Malaysia: a multilevel analysis
Mohd Rujhan Hadfi Mat DAUD ; Nor Azwany YAACOB ; Wan Nor ARIFIN ; Jamiatul Aida Md SANI ; Wan Abdul Hannan Wan IBADULLAH
Osong Public Health and Research Perspectives 2024;15(5):429-439
Despite effective vaccination strategies, measles remains a global public health challenge. The study explored individual and contextual factors associated with measles infection in Malaysia from 2018 to 2022, informing the development of targeted public health interventions. Methods: This cross-sectional study utilised data from the Ministry of Health, the Department of Statistics, and the Department of Environment Malaysia. Multilevel logistic regression analysis was employed to examine individual-level factors, including age, sex, ethnicity, nationality, contact history, travel history, and vaccination status. Concurrently, contextual factors were assessed, encompassing district-level determinants such as population density, median household income, urbanisation, the number of health and rural clinics, vaccination rates, fine particulate matter less than 2.5 μm (PM2.5) levels, relative humidity, and temperature, to determine their impact on measles infection risk. Results: Measles infection was significantly associated with various individual factors. These included age (adjusted odds ratio [aOR], 1.02; 95% confidence interval [CI], 1.02–1.03), ethnicity, non-Malaysian nationality (aOR, 34.53; 95% CI, 8.42– 141.51), prior contact with a measles case (aOR, 2.36; 95% CI, 2.07–2.69), travel history (aOR, 2.30; 95% CI, 1.13–4.70), and vaccination status (aOR, 0.76; 95% CI, 0.72–0.79). Among contextual factors, urbanisation (aOR, 1.56; 95% CI, 1.16– 2.10) and the number of clinics (aOR, 0.98; 95% CI, 0.97–0.99) were significant determinants. Conclusion: This multilevel logistic regression analysis illuminates the complexities of measles transmission, advocating public health interventions tailored to individual and contextual vulnerabilities. The findings highlight the need for a synergistic approach that combines vaccination campaigns, healthcare accessibility improvements, and socioeconomic interventions to effectively combat measles.
8.Individual and contextual factors associated with measles infection in Malaysia: a multilevel analysis
Mohd Rujhan Hadfi Mat DAUD ; Nor Azwany YAACOB ; Wan Nor ARIFIN ; Jamiatul Aida Md SANI ; Wan Abdul Hannan Wan IBADULLAH
Osong Public Health and Research Perspectives 2024;15(5):429-439
Despite effective vaccination strategies, measles remains a global public health challenge. The study explored individual and contextual factors associated with measles infection in Malaysia from 2018 to 2022, informing the development of targeted public health interventions. Methods: This cross-sectional study utilised data from the Ministry of Health, the Department of Statistics, and the Department of Environment Malaysia. Multilevel logistic regression analysis was employed to examine individual-level factors, including age, sex, ethnicity, nationality, contact history, travel history, and vaccination status. Concurrently, contextual factors were assessed, encompassing district-level determinants such as population density, median household income, urbanisation, the number of health and rural clinics, vaccination rates, fine particulate matter less than 2.5 μm (PM2.5) levels, relative humidity, and temperature, to determine their impact on measles infection risk. Results: Measles infection was significantly associated with various individual factors. These included age (adjusted odds ratio [aOR], 1.02; 95% confidence interval [CI], 1.02–1.03), ethnicity, non-Malaysian nationality (aOR, 34.53; 95% CI, 8.42– 141.51), prior contact with a measles case (aOR, 2.36; 95% CI, 2.07–2.69), travel history (aOR, 2.30; 95% CI, 1.13–4.70), and vaccination status (aOR, 0.76; 95% CI, 0.72–0.79). Among contextual factors, urbanisation (aOR, 1.56; 95% CI, 1.16– 2.10) and the number of clinics (aOR, 0.98; 95% CI, 0.97–0.99) were significant determinants. Conclusion: This multilevel logistic regression analysis illuminates the complexities of measles transmission, advocating public health interventions tailored to individual and contextual vulnerabilities. The findings highlight the need for a synergistic approach that combines vaccination campaigns, healthcare accessibility improvements, and socioeconomic interventions to effectively combat measles.
9.Accelerometer-Measured Physical Activity and its Relationship with Body Mass Index (BMI) and Waist Circumference (WC) Measurements: A Cross-Sectional Study on Malaysian Adults
Lee Yi YI ; Narimah SAMAT ; Wan Manan Wan Muda
Malaysian Journal of Nutrition 2017;23(3):397-408
Introduction: Physical activity has been shown to be beneficial for the prevention of obesity and non-communicable diseases. Our contemporary way of life that is technology dependent has significantly reduced physical activity. This study aimed to determine accelerometer-measured physical activity (moderate-to-vigorous physical activity (MVPA)) among adults in high and low walkability neighbourhoods in Penang and Kota Bharu, Malaysia. Methods: Participants (n=490) were sampled using multistage sampling method from neighbourhoods with varied levels of walkability using Geographical Information System (GIS). Physical activity was measured objectively using Actigraph GT3X+ accelerometers, worn by the participants on their waists for a period of 5 to 7 days. Results: The participants had a mean of 13.5 min/day of MVPA. Total MVPA was significantly higher among participants in high walkability neighbourhoods (19.7 min/day vs. 9.1 min/ day). Results from t-test showed that the time spent on MVPA per day was significantly lower among participants residing in low walkability neighbourhoods. The final model of the MIXED model statistical tests showed that total MVPA was significantly associated with BMI, but not with WC measurements, after adjusting for covariates. Conclusion: Most of the participants had very low MVPA and did not achieve the current physical activity recommendations, implying that Malaysian adults residing in these two cities were not physically active to achieve health benefits. Results are suggestive of the importance of the walkability concept in neighbourhoods in encouraging physical activity and healthy body weight among Malaysians.
10.Parotid gland oncocytic carcinoma: A rare entity in head and neck region
The Malaysian Journal of Pathology 2020;42(2):283-286
Oncocytic carcinoma of the salivary gland is an uncommon tumour in the head and neck region.
Owing to its rarity, identifying the histopathological features of a malignant tumour can be difficult
and challenging. We report a case of a 70-year-old man who presented with a left facial weakness
for six months in a background history of left parotid swelling over the past 10 years. Clinical
examination revealed a 3x3cm left parotid mass and grade 4 facial nerve palsy. Fine needle aspiration
of the mass showed scattered cohesive, monolayered sheets of uniform oncocytic cells. Subsequently,
a left total parotidectomy and selective neck dissection were performed. Histological examination
showed sheets of small oncocytes with minimal nuclear atypia. Evidence of nerve entrapment,
capsular invasion and perivascular permeation were identified in focal areas. Thus, a final diagnosis
of oncocytic carcinoma was rendered.