Objective To analyze the current situation of the professional spirit of nursing students in a medical college in Xinjiang,and to explore its influencing factors.Methods In March 2017,a questionnaire was self-designed to analyze the influencing factors of professional nursing students' professional spirit,including 31 items in three parts,including basic information,professional interns' occupational mental influence factors and the status quo of professional spirit and attitude of nursing interns.328 nursing students in a medical college in Xinjiang were investigated.325 valid questionnaires were withdrawn and verified,and 3 questionnaires were lost,with an effective rate of 99.09％.EpiData 3 was used to build the database and SPSS 17.0 line multiple regression analysis was applied.Results Occupation status statistics showed that the mental attitude,"I hope to excellent nursing teacher learning" "I have been through my nursing can help patients relieve pain" and "good occupation spirit is excellent nurses necessary conditions I think the nursing staff is the medical profession indispensable professional personnel",in line with the percentage was 95.08％,94.15％,94.15％,93.85％ respectively.Multiple regression analysis showed that there were three statistical significance (P＜0.05) for "whether to be a class cadre in school","the reason for choosing nursing specialty" and "post graduate employment plan".Conclusion "Whether to be a class cadre in a school" "to choose the cause of nursing specialty" "post graduate employment plan" may be the main factor affecting the professional spirit of the nursing professional students.This shows that in the future education of nursing students,we should focus on training students' devotion to work and dedication.We should take into account to training their organizational capabilities and encourage them to become student leaders.