Objective: To explore the effect of sports application (APP) based on goal oriented management physical exercise among college students. Methods: A total of 172 college students without sports APP experience were selected from Changzhou College of Information Technology during July to December in 2019. All the participants were divided into intervention group and control group by random number table method (both 86 cases). The control group was given routine management of college students sports APP, while the intervention group was given goal oriented sports APP management. After 16 weeks of intervention, health literacy, physical exercise and physical quality of the two groups were compared. Results: After intervention, the total score of health literacy among students in the intervention group was (55.52±7.21) points, and that in the control group was (50.99±7.13) points, and the difference was statistically significant( t=4.14, P <0.05). After intervention, the total score of physical exercise behavior of students in the intervention group (126.89±17.45) was significantly higher that in the control group (117.39±16.32)( t= 3.69 , P <0.05). After intervention, the 50 m running, standing long jump, pull up, 1 000 m running and sitting forward bend of male students in the intervention group were (7.52±0.71)s, (227.46±7.15)cm, (6.56±1.02)times, (262.20±13.24)s, (8.34± 1.02 )cm, and (7.93±0.75)s, (223.74±8.24)cm, (5.94±0.93)times, (268.15±11.45)s, (7.56±1.15)cm for the control group, the differences were statistically significant( t values were -2.76, 2.36, 3.13, -2.37, 3.76, all P <0.05). The 50 m running, standing long jump, sit ups, 800 m running, and sitting forward bending among female students of the intervention group were ( 9.38 ±1.12)s, (170.23±8.24)cm, (28.50±2.25)times, (252.13±15.34)s, (11.35±2.13)cm, and (10.07±1.10)s, (165.47± 8.52 )cm, (27.15±3.12)times, (264.35±14.56)s, (10.41±1.36) cm for the control group, all with statistical significance( t values were -2.68, 2.46, 2.17, -3.52, 2.24, P <0.05). Conclusion The sports APP based on goal oriented management could help promote health literacy, physical exercise, and physical quality among college students.