Lung cancer is one of the most common malignant tumors in the world,of which non-small cell lung cancer(NSCLC)is the majority.The emergence of immune checkpoint inhibitors(ICIs)has greatly changed the treatment strategy of NSCLC and improved the prognosis of patients.However,in reality,only a small number of patients can achieve long-term benefit.Therefore,the identification of reliable predictive biomarkers is essential for the selection of treatment mo-dalities.With the development of molecular biology and genome sequencing technology in recent years,as well as the in-depth understanding of tumor and its host immune microenvironment,research on biomarkers has emerged in an endless stream.This review focuses on the predictive biomarkers of immunotherapy efficacy in NSCLC,in order to provide some guidance for precision immunotherapy.