1.Myeloid sarcoma occurring in the gingiva: a case report.
Yuhong WU ; Wei Lü ; Ruimei WANG
West China Journal of Stomatology 2015;33(1):107-108
Myeloid sarcoma (MS) is a localized extramedullary mass of immature granulocytic cells. MS may be found in any location, but intraoral occurrence is rare. This report presents a case of MS in the gingiva.
Gingiva
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Gingival Neoplasms
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Humans
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Sarcoma, Myeloid
2.Clinical and pathological analysis of Wegener granulomatosis in children
Yuhong TAO ; Songhui ZHAI ; Zheng WANG
Chinese Pediatric Emergency Medicine 2007;14(z1):28-30
Objective To analyze the clinical and pathological features of Wegener granulomatosis (WG) in children in order to improve the understanding of this disease. Methods Nine cases of WG,including two cases from our hospital and seven cases throughout the country,were analyzed in aspects of their clinical characteristics,laboratory examinations,X-ray and treatments. Results Of the nine cases,six cases were male and three cases were female with average age of twelve years old. The average time from the initiation of clinical symptom to diagnosis was 8.3 months. Patients had multiple systems and organs involvements. Lung and kidney involvement were the most common. Six out of seven were positive in c-ANCA and anti-PR3 antibody. Biopsy was conducted in eight patients,and pathological manifestations involved parenchymal necrosis,granulomatosis,vasculitis and so on. Most patients improved significantly after being treated with glucocorticoids and cyclophosphamide. Conclusion WG is a syndrome which involves many organs without distinctive clinical manifestation. An ANCA test should be performed to make an early diagnosis.
3.Experimental study on therapeutic effects of Ginsenoside on Alzheimer's disease
Longan WANG ; Yuhong MA ; Wei LI
Clinical Medicine of China 2008;24(7):680-682
Objective To study the effects of ginsenoside on expression of inducible nitric oxide synthase and concentration of NO in THP-1 induced by amyloid beta(Aβ) in Alzheimer's disease. Methods The concentra- tion of nitric oxide was determined by Griess Reagent in supernatant of THP-1. The content of iNOS was measured by western blotting. Results The expression of iNOS of model group was significantly higher than those of control group. Compared with model group, the ginseng could reduce expression of iNOS and concentration of NO significant- ly in THP-1. Conclusion Ginsenoside can significantly inhibit the expression of iNOS, and reduce secretions of NO, so it may provide a novel therapy for AD.
4.Activation of adenosine A_1 receptor inhibits glucose-induced cardiomyocyte hypertrophy
Yali HAN ; Yuhong YANG ; Hongxin WANG
Chinese Pharmacological Bulletin 2010;26(4):531-535
Aim To demonstrate the effects and mechanism of adenosine A1 receptor agonist R(-)-N6-(2-phenylisopropyl) adenosine(R-PIA) on high glucose(HG)-induced myocardial hypertrophy by in vitro cultured myocardial cells from neonatal rats.Methods The protein content was assayed by the method of Lowry. The expression of p-ERK1/2 and ERK1/2 was determined by Western blot.The [Ca~(2+)]I transient changes of cell loaded Fura-2/AM were measured by Till image system.Results 1 μmol·L~(-1) R-PIA and U0126 inhibited similarly HG-induced increase of the protein content and [Ca~(2+)]I transient along with the relative expression of p-ERK1/2.These responses were completely abolished by adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine(CPDPX).Conclusion Adenosine A1 receptor stimulation significantly inhibits HG-induced myocardial hypertrophy by mediating ERK1/2 pathway and Ca~(2+).
5.N-acetylcysteine attenuates myocardial hypertrophy in streptozotocin-induced diabetic rats
Yuhong HE ; Zhongyuan XIA ; Fang WANG
Chinese Journal of Diabetes 2010;18(3):211-213
Objective To investigate the protective effect of N-acetylcysteine(NAC) on the development of myocardial hypertrophy in diabetic rats induced by streptozotocin. Methods Male SD rats were randomly divided into normal control (NC), control treatment (NCT), diabetic (DM) and diabetes treatment (DMT) groups. NAC was administered at dose of 1.4~1.5g·kg~(-1)·d~(-1) to NCT and DMT groups in the drinking water for 8 weeks. At termination the rats were surgically prepared for hemodynamic measurement, such as systolic blood pressure, heart rate, the rate of left ventricle relaxation (-dp/dt) and the time to maximum relaxation (T). Subsequently, the hearts were removed to assay relative ratio of left ventricle weight versus body weight (LVW/BW) and cardiomyocyte cross sectional areas.Plasma glucose, insulin, 15-F_(2t)-isoprostane(15-F_(2t)-Isop) concentration and superoxide dismutase (SOD) activity were analyzed. Results The LVW/BW ratio and cardiomyocyte areas were significantly attenuated by NAC treatment as compared to DM group (P< 0.05). Increases in -dp/dt and SOD activity and the decreases in glucose, 15-F_(2t)-Isop T (P< 0.05) were found at the same time. Conclusions NAC can effectively prevent the development of myocardial hypertrophy and improve diastolic function in diabetic rats, which may be related to its antioxidant capacity.
6.Experimental Study of Effect of Aluminum on Learning and Memory and the Changes of Synaptic Interface Constructure in Hippocampus CA3 Area in Rats
Yuhong JING ; Shenyuan FENG ; Fei WANG
Progress of Anatomical Sciences 2001;7(1):4-6
Objective To study the effect of aluminum on learning and memory and the synaptic interface constructure in hippocampus CA3 area in rats. Methods The electrical maze were used to test the behavioral reaction of rats. Some parameters of synaptic interface structure were measured by the method of ultrastructural quantitative analysis in hippocampus CA3 area in the rats. Results The time coming through the E-maze prolonged siginificantly in the experimental group compared with the normal control (P<0.01), meanwhile the cyto-apparatus demonstrated the pathogenetic changes. Amounts of synapse obviously reduced and the post-synaptic density turned thinner in experimental group than in the control group (P<0.01). Conclusion Aluminum can cause the malfunction on learning and memory, which related to the plastic of synapse.
7.A P-wave detection method based on multi-feature.
Lixin SONG ; Lili GUAN ; Qian WANG ; Yuhong WANG
Journal of Biomedical Engineering 2014;31(2):283-287
Generally, P-wave is the wave of low-frequency and low-amplitude, and it could be affected by baseline drift, electromyography (EMG) interference and other noises easily. Not every heart beat contains the P-wave, and it is also a major problem to determine the P-wave exist or not in a heart beat. In order to solve the limitation of suiting the diverse morphological P-wave using wavelet-amplitude-transform algorithm and the limitation of selecting the pseudo-P-wave sample using the wavelet transform and neural network, we presented new P-wave detecting method based on wave-amplitude threshold and using the multi-feature as the input of neural networks. Firstly, we removed the noise of ECG through the wavelet transform, then determined the position of the candidate P-wave by calculating modulus maxima of the wavelet transform, and then determine the P-wave exist or not by wave-amplitude threshold method initially. Finally we determined whether the P-wave existed or not by the neural networks. The method is validated based on the QT database which is supplied with manual labels made by physicians. We compared the detection effect of ECG P-waves, which was obtained with the method developed in the study, with the algorithm of wavelet threshold value and the method based on "wavelet-amplitude-slope", and verified the feasibility of the proposed algorithm. The detected ECG signal, which is recorded in the hospital ECG division, was consistent with the doctor's labels. Furthermore, after detecting the 13 sets of ECG which were 15 min long, the detection rate for the correct P-wave is 99.911%.
Algorithms
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Databases, Factual
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Electromyography
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Heart Rate
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Humans
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Neural Networks (Computer)
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Wavelet Analysis
8.Clinical research in humanistic care and psychological care in patients after breast cancer surgery
Xuemin ZHANG ; Cui WANG ; Shuhua WANG ; Yuhong PAN
Chinese Journal of Practical Nursing 2011;27(14):16-18
Objective To discuss the promoting effect of humanistic care plus psychological cage on basis of conventional nursing on rehabilitation of patients after breast cancer surgery.Methods 460 cases of breast cancer patients from January 2008 to January 2010 were randomly divided into the control group and the observation group with 230 cases in each group.The control group received routine nursing care after surgery,while for the observation group,in addition to conventional care,they received humanistie care and psychological care.The alleviation degree of psychological barrier and degree of satisfaction of the two groups were compared.Results The alleviation degree of psychological barrier was 62.2% .and was 40.4% in the control group.The patients'satisfaction rate was 95.2% in the observation group,and 71.7% in the control group.the difference Was significant.Conclusions Humanistic care and psychological care can effectively relieve mental disorders of patients,promote their early recovery,also can improve their satisfaction degree with nursing work.
9.The common targets of preconditioning and postconditioning in the treatment of cerebral ischemia
Yu WANG ; Yumin LUO ; Yuhong ZHU ; Xunming JI
International Journal of Cerebrovascular Diseases 2009;17(10):787-791
As an endogenous organism protective measure in vivo, preconditioning/ postconditioning in the process of ischemia/reperfusion may play common protective mechanisms, such as reducing the generation of oxygen free radicals, activating adenosine receptor, increasing endogenous nitric oxide and heat shock protein, inhibiting immune inflammatory response and neuronal apoptosis, activating intracellular signal transduction pathways, opening mitochondrial ATP-sensitive potassium channels, as veil as closing mitochondrial permeability transition pores. Investigating the common target of these mechanisms may provide a new theoretical basis for developing new drugs and reducing ischemia/reperfusion injury.
10.Protective effects of remote organ ischemic preconditioning on cerebral ischamia
Ying WANG ; Yumin LUO ; Yuhong ZHU ; Xunming JI
International Journal of Cerebrovascular Diseases 2009;17(3):215-219
Remote organ ischemic preconditioning is to conduct a transient and sublethal ischemic adaptation in non-vital organs before occurring cerebral ischemia/reperfusion injury in remote vital organs. Remote organ iscbemic preconditioning has been studied for as long as 15 years in the field of myocardial iscbemia. However, only recently it has become a therapeutic strategy for the treatment of cerebrovascular diseases, This article briefly reviews the methods and mechanisms involved in the protective effects of cerebral ischemia of remote organ ischemic preconditioning.