Sepsis is a major cause of mortality among children and newborns.The largest part of the global pediatric sepsis burden occurs in middle-and low-income countries,where the mortality of sepsis reaches 24％-50％.It is necessary to provide clinicians with a framework to improve the management of pediatric septic patients.The key of treatment is to ensure adequate tissue perfusion,to maintain cardiovascular and hemodynamic stability,the administration of adequate antibiotics,the proper use of glucocorticoid,and so on.

Objective:To investigate the effect of IRH on pulmonary fibrosis and its intervention mechanism.Methods:45 sprague-dawley rats were randomly divided into three groups.The model group and the intervention group were received endotracheal injection of bleomycln to induce pulmonary fibrosis,while the control group were received endotracheal injection of saline.From the second day the intervention group IRH were injected to the stomach,while the other two groups were injected saline instead.On the 7th day,14th day and 28th day the lungs were isolated.The expression of MMP-2 and TIMP-1 was detected by immunohistochemical method respectively.Results:There was only a very weak expression of MMP-2 and TIMP-1 in the control group,there was significantly higher level in model group compared with control group on the 7th day,14th day and 28th day.The IRH group was significantly lower than the model group with the same time points,though it was also obviously higher than the control group all over the period(P

Objective To observe the curative effect of acupuncture point bloodletting,flash tank combined with ultrashort wave auxiliary in the treatment of infantile cough.Methods 102 children with cough were selected and randomly divided into control group (50 cases)and observation group (52 cases).The control group adopted general anti -infection,reduce phlegm,the method of atomizing inhalation.The observation group received control method based on the acupuncture point thorn bloodletting,cans,combined with ultrashort wave.The clinical curative effect was compared in the two groups.Results In the treatment group,34 cases got cure,improvement in 17 cases, 1 case had no effect,the cure rate was 65.3%,total effective rate was 98.0%,without efficiency 1.9%.In the control group,18 cases got cure,improvement in 23 cases,9 cases of invalid,and the cure rate was 36.0%,the total effective rate was 82.0%,without efficiency was 18.0%.The total effective rate between the two groups had statistically significant difference (χ2 =4.105,P <0.05).Conclusion Acupuncture point bloodletting,flash tank combined with ultrashort wave auxiliary in the treatment of infantile cough can obviously improve the clinical effect.

Fractal is a new conception.In this paper some knowledge of fractal is first described.Our research work of fractal application in Doppler ultrasound technique is reported.

CD4 +T cells from patients with human immunodeficiency virus (HIV) infection undergo apoptosis at an enhanced rate, which leads to immune system damage and invalidation to withstand the virus intrusion. The current antiviral drugs aim at the virus can not clear the chronically infected cells which are the virus reservoirs. But treatment of HIV/AIDS patients with the HIV protease inhibitors (PIs) can reduce the cell apoptosis induced by HIV infection, which can improve immune function, and that is separate from the antiviral effects of PIs. Such suggests that immune reconstruction is a new strategy to cure AIDS. This text reviews HIV PIs research and development, their function characteristics and the effects on cell apoptosis. To define the relationship between HIV PIs and cell apoptosis may inspire new ways of curing the AIDS.-

Objective To increase the speed of thermoacoustic imaging, a deconvolution reconstruction (DR) algorithm is proposed for small-scale need detecting living beings, on the basis of deconvolution of thermoacustic imaging algorithm. Methods A new function was firstly constructed from the detected acoustic pressure function. Then, the distribution of electromagnetic wave absorption coefficient of the need detecting living beings could be reconstructed from this new function based on the deconvolution method. Computer simulation studies were carried out to compare the DR algorithm with the two popular algorithms: the time-domain reconstruction (TDR) and the filtered back projection (FBP). Results For small-scale need detecting living beings, the accuracy of DR was nearly equivalent to TDR and slightly better than FBP. However, DR was about 4 to 6 times faster than TDR and about 25 to 100 times faster than FBP under the simulation experiment condition. Conclusion DR is a fast and effective algorithm of thermoacoustic imaging for small-scale living beings.

Objective To study the method based on gradient vector flow (GVF) and particle swarm optimization (PSO) for realizing multimodal medical image registration and improving its accuracy. Methods In view of three major components of image registration, i.e. the feature space, the similarity metric and the search strategy, a novel method was proposed with three improvements. Firstly, the GVF field was employed as the feature space. Then three similarity metrics were proposed based on GVF field. Finally, an improved PSO combined with crossover mechanism of genetic algorithm was utilized to search for the optimal transformation of two images. Results With 54 times of experiments on both simulated and real medical images, it was demonstrated that this method accurately registered the multimodal medical images to be superior to the method based on PSO of pixels, and the Walsh transform method. Conclusion The method based on GVF and PSO is effective for multimodal medical image registration.

ObjectivesTo study the clinical characteristics, the risk factors and outcomes of arterial ischemic stroke (AIS) and hemorrhagic stroke (HS) in children.MethodsThe clinical data from 142 children with AIS or HS were retrospectively re-viewed and compared from Nov. 2010 to May 2014.ResultsIn these children, 92 cases (64.8%) was diagnosed of AIS, amont whom there were 60 males and 32 females and the onset age of stroke was 4.6±3.6 years (1 months to 16 years old), and 50 cases (35.2%) was diagnosed of HS, among whom there were 34 males and 16 females and the onset age of stroke was 2.6±3.7 years (1 months to 13 years old). The difference in age between two groups was statistically signiifcant (P=0.007). The most common presentation of AIS were focal neurological dysfunction including paralysis (73 cases, 79.3%), central facial palsy (30 cases, 32.6%) and speech impairment (19 cases, 20.7%). The most common presentation of HS were diffuse neurological dysfunction including dizziness (29 cases, 58.0%), nausea/vomiting (22 cases, 44.0%) and headache (14 cases, 28.0%). The major risk factors of AIS were arteriopathy (49 cases, 53.3%), infection (47 cases, 51.1%) and minor head injury (16 cases, 17.4%). The major risk factors of HS were vitamin K deifciency (22 cases, 44.0%), intracranial vascular anomalies (8 cases, 16.0%) and haematological disorders (6 cases, 12.0%). Five cases (6.4%) were died, 48 cases (61.5%) became disabled and 9 cases (11.5%) were relapsed in children with AIS while 15 cases (34.1%) were died, 19 cases (43.2%) became disabled in children with HS. The mortality was signiifcantly higher in children with HS than that in children with AIS (P<0.01).ConclusionsIn childhood stroke, HS occurs more frequently than is commonly appreciated and it has a poorer prognosis than AIS.

Objective To explore the application of partial least square regression model in the study of personality characteristics of the scientific personne1,to supply more reliable and scientific rationale to the training and intelligent use of scientific personne1 in colleges.Methods We took our survey by 114 scientific personnel from eight universities with NEO-PI-R(Revised NEO Personality Inventory).After the process of simplifying the NEO-PI-R,we need partial least square regression model to analyze.Results The results of the PLS analysis indicates the goodness-of-fit of the model was good,which opened out clearly and intuitively the connection between the items and five personality characteristics,the model could be used as theory reference for personnel department,research department and education department to consummate the training of scientific personne1 in colleges.Conclusion Partial least square regression model could be used to study personality characteristics of the scientific personne1 in colleges as statistic method appearing recently.

Objective To create a sterilized condition in field operation and the daily grind avoiding the intercross contamination between the experimentation and outside. Methods The air in the experimentation was filtrated by primary and advanced filter. High intense ultraviolet was used to sterilize the air, and negative compression was kept in the experiment condition. Results Hyperpurificatory biosafety cabinet guaranteed the sterilization condition in field operation and the daily grind, avoiding the intercross contamination. Conclusion Hyperpurificatory biosafety cabinet can be used in medical treatment, pharmacy, food industry, electrical industry, instrumentation, bioengineering, scientific tests, especially biology species identification in biological warfare.