The incidence of malnutrition among patients with chronic kidney disease (CKD) constantly increases despite the development of health care and dialysis techniques.New nutritional targets for CKD patients upon maintenance treatment have been developed.Before dialysis,evidences have shown that a long-term nutritional care plan,with a control of protein intake,can effectively correct metabolic disorders including proteinuria and acidosis.During the maintenance dialysis,the optimal protein and energy intakes have been recently challenged.The new classification of nutritional disorders in CKD patients may help the easily identification of protein-energy wasting.

Objective If IL-2 and IFN-? are united,perhaps we may see a more significant antitumor effect.A fusion gene of IL-2 and IFN-? was designed and constructed by DNA engineering.Methods CEA promotor、IL-2cDNA and IFN-?cDNA were obtained by PCR and RT-PCR.SDS-PAGE was used to examine the results;pcDNA-IL-2、pcDNA-IFN-?、pCEA-IL-2/ IFN-?、pEGFP-IL-2/ IFN-? were transfected to CEA high expression cell line(Lovo)by use of liposome.The fusion protein expression was examined by fluorescence microscope and Western blotting.Results IL-2/ IFN-? fusion gene can be expressed in tumor cells.Its expression is more obvious in CEA high expressed cells(Lovo),and can be located in cell plasma.Conclusion The fusion gene can be expressed in plasma of CEA high expressed cell lines.It may have a new anti-tumor effects.

The initiation and development of diabetic chronic complications is associated not only with the level of blood glucose,but also with the glucose fluctuation.The damage in large artery and microvessel may be caused by glucose fluctuation.There are two causes which induce glucose fluctuation in clinical:one is postprandial hyperglyceamia with not well controlled,the other is hypoglycemia causes by unsuitable therapy.A lot of effective new types of substances were applicated in clinical,such as ?-glucosidase inhibitor,glinide-insulin secretagogus,fast-acting and long-acting insulin analogues.With these new powerful tools,there is possibility to treat diabetes more correctly and safely,and control the blood glucose in a stable and good level.

Humans ; Osteotomy ; adverse effects ; methods ; Scoliosis ; surgery

Humans ; Minimally Invasive Surgical Procedures ; Spine ; surgery

Arthroplasty, Replacement, Hip ; trends ; China ; Hip Prosthesis ; Humans ; Prosthesis Failure

Humans ; Intraoperative Complications ; Osteotomy ; adverse effects ; methods ; Postoperative Complications ; Spine ; surgery

OBJECTIVE:To study the anticoagulative and antithrombotic activity of Tongsai ruanmai tablets.METHODS:The effects of Tongsai ruanmai tablets on coagulation time, prothrombin time(PT),the fibrinogen(Fbg) content and the dissolution rate of blood clot were observed. The antithrombotic effect of Tongsai ruanmai tablets was also studied by thrombogenesis dissolution test in vivo and in vitro in rats. RESULTS: At the dose of 0.5, 1.0 and 2.0 g?kg-1,Tongsai ruanmai tablets could significantly prolong the coagulation time and PT in rats, decrease the Fbg content, increase the dissolution rate of blood clots, prolong carotid artery thrombosis formation time, shorten the length of thrombosis of rats in vitro, lessen the wet weight and dry weight of thrombosis of rats.CONCLUSION:Tongsai ruanmai tablets possess anticoagulative and antithrombotic activity.

Objective To investigate the clinical effect and safety of microwave thermosetting joint pingyangmycin injected within the occlusion in treatment of maxillofacial hemangioma.Methods The clinical data of 102 patients with maxillofacial hemangioma were retrospectively analyzed.According to the different period of the different choice of treatment,the patients were divided into microwave thermosetting group and surgery group.The clinical effect,treatment time and hairdressing effect of the two groups were analyzed.Results Total effective rate of microwave thermosetting group was 96.30％,surgery group was 95.83％,the difference between the two groups had no statistical significance (x2 =0.153,P ＞ 0.05).The average surgical time of surgery group was obviously shorter than microwave thermosetting group(t =7.625,P ＜ 0.01),but satisfaction of hairdressing effect in microwave thermosetting group was obviously higher than that of the surgery group(90.74％ vs 75.00％,x2 =4.533,P ＜0.05),the incidence rate of adverse reaction was significantly lower than the surgery group(5.56％ vs 18.75％,x2 =4.262,P ＜ 0.05).The facial nerve injury occurred in 3 patients (6.2 5 ％) after operation in the surgery group,microwave thermosetting group had no facial nerve injury after treatment.There was no recurrence after follow-up for 6 months.Conclusion The clinical effect and hairdressing effect of microwave thermosetting joint pingyangmycin injected within the occlusion in treatment of maxillofacial hemangioma are satisfied,the incidence rate of adverse reaction and complication is relatively low.It is safe and effective,which is worth expanding in clinical practice.

Many transcription factors, kinases and phosphorylase regulate the expression and activity of stuthmin. The abnormality of stathmin expression or its activity is closely involved in lots of pathological or phys-iological events such as cell proliferation, development of tumor. Many kinds of malignant tumors have high ex-pression of stathmin, and inhibiting the expression of stathmin protein is a new biotherapy target in tumor geneth-erapy. Moreover, stathmin protein can influence curative effect of some chemotherapeutics ,which target microtu-bular. This has some significance with regard to the guidance of clinical medication.