At present, coronary stent has been extensively used in clinic. It can significantly improve acute obstruction complication and vascular restenosis following percutaneous transluminal coronary angioplasty. However, restenosis also takes place after stent implantation, in particular for complex pathological changes. It has been demonstrated that thrombus, inflammation, and smooth muscle hyperplasia are three important stages for in-stent restenosis, and vascular intima hyperplasia is the major mechanism. After retrieving related articles, this paper discussed biocompatibility and restenosis of metal stent and drug-eluting stent, analyzed influence of stent implantation on collateral circulation function and inflammatory reactions, and explored the application of biodegradable stent.

Objective To investigate the correlation of serum adiponectin (APN),C-reactive protein (CRP) levels and carotid atherosclerosis plaque in patients with acute cerebral infarction (ACI).Methods Sixty patients with ACI (ACI group) were diagnosed by head CT and MRI examination.And sixty cases of healthy check-up were as control group.The serum APN and CRP were examined by double antibody sandwich enzyme linked immunosorbent assay method,and carotid atherosclerosis was examined by ultrasound.Results The serum APN and CRP levels in ACI group were (4.36 ± 2.54),(8.93 ± 2.89)mg/L,and in control group were (8.43 ± 3.51),(1.12 ± 0.52) mg/L.The serum APN level in ACI group was significantly lower than that in control group,and the serum CRP level in ACI group was significantly higher than that in control group (P ＜ 0.05).In ACI group,the serum APN level after treatment was significantly increased compared with that before treatment,the serum CRP level after treatment was significantly decreased compared with that before treatment.The differences were (6.44 ± 2.31) and (4.10 ± 0.72) mg/L respectively.The rate of carotid atherosclerosis in ACI group was 78.33％ (47/60),and the rate of carotid atherosclerosis plaque was 71.67％(43/60).The stable plaque was in 13 cases and instability plaque was in 30 cases.The rate of carotid atherosclerosis in control group was 26.67％(16/60),and the rate of carotid atherosclerosis plaque was 13.33％(8/60).The stable plaque was in 6 cases and instability plaque was in 2 cases.The differences between the two groups had statistical significance (P ＜ 0.05).In ACI group,the serum APN and CRP levels in ACI without carotid atherosclerosis plaque were (6.89 ± 2.37) and (5.41 ± 1.38)mg/L,in ACI with carotid atherosclerosis plaquewere (3.28 ± 1.99) and (9.42 ±3.70) mg/L.Carotid atherosclerosis plaque and serum APN level showed negative correlation (r =-0.76,P ＜ 0.05),and serum CRP level was positively correlated (r =0.81,P ＜ 0.05).The serum APN and CRP levels in ACI with stable plaque were (4.32 ± 2.14) and (6.65 ± 2.69) mg/L,in ACI with instability plaque were (2.11 ± 1.35) and (10.11 ± 3.82) mg/L.Carotid artery plaque stability and serum APN level showed negative correlation (r =-0.69,P ＜ 0.05),and serum CRP level was positively correlated (r =0.77,P＜ 0.05).Conclusions The occurrence of ACI is closely related to carotid atherosclerotic plaque.The serum APN level in ACI patients is significantly lower than that in normal crowd,but serum CRP level in ACI patients is significantly higher than that in normal crowd.The rate of carotid atherosclerosis is significantly increased,most of which is instability plaque.Carotid atherosclerosis plaque and serum APN level has negative correlation,and serum CRP level is positively correlated.Carotid artery plaque stability and serum APN level has negative correlation,and serum CRP level is positively correlated.

OBJECTIVE:To investigate the compatible stability of cefepime dihydrochloride mixed with total parenteral nutrient(TPN). METHODS:Cefepime dihydrochloride mixed with TPN at room temperature for 24 h. The appearances of the mixture were observed at 0,2,4,6,8,10,24 h and the change of pH value was evaluated. The contents of cefepime dihydrochloride were determined by HPLC. RESULTS:No change was observed in the contents of cefepime dihydrochloride in total parenteral nutrient within 24 h. There was no significant change in the appearance,color and pH value of nutrient. CONCLUSION:At room temperature cefepime dihydrochloride in TPN is stable within 24 h.

Objective To characterize the clinical features of patients with high level of carbohydrate antigen (CA)724 in order to facilitate the recognition of this clinical manifestations.Methods Eight-two cases of hospitalized patients diagnosed with gout were selected and divided into 2 groups according to the level of CA724,and the clinical features and laboratory indexes were compared between the 2 groups.T test was used in the numerical variable data between groups,x2 test was used in the categorical variable data.Correlation analysis was tested using Spearman analysis.Results The incidence of gout stones in the group with high level of CA724 was 61％,which was significantly higher than that in the group of normal CA724 of 28％.There were statistically significant differences between the two groups (x2=8.894,P＜0.05).The incidence of kidney stones in the group with high level of CA724 was 65％,which was significantly higher than that in the group of normal CA724 of 22％.There were statistically significant differences between the two groups (x2=15.013,P＜0.05).But there were no statistically significant differences in age of onset,blood uric acid,erythrocyte sedimentation rate,and serum creatinine between the two groups (P＞0.05).Conclusion The significantly elevated level of CA724 canappeare in gout patients,But it isnotcorrelated with tumor,which should be paid attention by clinician.It helps to avoid unnecessary checks and reduce the psychological and financial burden of patients.

Since human imprinted genes in 11P15.5 was found,it had been proved that various human physiological abnormality associated with it.As one of the first identified imprinted non-coding RNA genes,more attention is paid to lncRNA H19 by many scholars not only because it's linked with Beckwith-Wiedemann syndrome (BWS) and Russell syndrome (SRS),but also H19 gene is the only imprinted gene belonging to long non-coding RNA related with a variety of tumors which can also produce microRNA675 and lncRNA 91H coming from H19 gene antisense-coding.This paper will review possible mechanisms of H19 gene in tumorigenesis process and its research status in Cancer therapy from four aspects:imprinting feature,single nucleotide polymorphisms,lncRNA character and its possible action signal axis in cancer.

Isolated hepatic perfusion(IHP)is the best re gional chemotherapy modal ity for treatment of unresectable liver primary cancer and liver metastases.The main principle of isolated hepatic chemotherapy is to achieve higher regional d rug concentrations and thus higher exposure of tumor tissue to the agents,resul ting in increased response rates,while shielding the organism from the systemic toxicity because of the much lower concentrations in the systemic circulation.At present the methods of IHP include surgical methods and methods with balloon c atheter technique,which promise to provide a micro-invasive procedure,bu t are not fully mature.The key point of successful IHP is low leakage or leakage-free.The more beneficial aspect of IHP is that it can simultaneously apply hyperthe r my and biologic agent TNF to improve sensitivity of chemotherapy,which is not p ossible in other regional chemotherapy.From previous literatures this overview is to describe the principle,procedure techniques,leakage monitor methods,hyp erthermy application,administration agents,therapeutic reaction,complications and perspective of IHP.

Objective To compare the effect of Gegensu Injection and Chinese Traditional Medicine on Chronic Renal Failure.Methods 70 cases of Chronic Renal Failure were selected as group A, treated by Gegensu Injection; During the same term,60 cases of Chronic Renal Failure were selected as group B, treated by Chinese Traditional Medicine and Chinese Traditional Medicine Clyster. The effect of two methods were valued by analyzing the numeral value of Scr and BUN in two groups . Results 1.Significant effective rate is 8.57, effective rate 41.42, ineffective rate 50, total effective rate 50 in group A; 23.33, 41.67, 35, 65 in group B. 2. After treatment, the numeral value of Scr and BUN in group A had significant difference (P

Objective To study the epidemical status of notifiable infectious diseases in navy from 1992 to 2006,in order to set a scientific basis for working out the measures of preventing from infectious diseases.Methods The reported data were classified by the current national approach and descriptively analyzed concerning infectious diseases during a period of 1992 to 2006 based on the Infectious Disease Surveillance and Reporting System of Chinese PLA.Results 6626 cases of 34 different notifiable infectious diseases were reported in PLA Navy during 1992-2006.Class A,B and C notifiable infectious disease were all reported.There was one death case.Viral hepatitis,dysentery and pulmonary tuberculosis ranked the top situation composing 78.84% of the total cases.The types of infectious diseases during 1992-1999 were less than that during 2000-2006,while the incidence was opposite.Gastrointestinal diseases were the major infectious diseases,accounting for 50.89%.The reported incidence of gastrointestinal diseases declined,and that of respiratory diseases ascended.Blood-borne and sexually transmitted infectious diseases accounted for 18.04%.Natural focal and arthropod-borne disease accounted for 4.95%.Conclusion Certain achievements in prevention and control of infectious diseases have been made since the present century.However,gastrointestinal and respiratory diseases should remain to be regarded,especially for viral hepatitis,pulmonary tuberculosis,dysentery,chicken pox and mumps.In the meantime the propaganda and education on the knowledge of disease prevention should be strengthened among the focus groups.

The effects of sophoramine (SA) on myocardial infarction size and ischemia－induced and reperfusion－induced arrhythmia were studied in conscious rats. It was found that pretreatment with SA 13.3 and 15 mg/kg iv reduced significantly infarct size and cardiac LDH release at 6h afte left descending coronary artery ligation as compared with the control. SA 10.6, 13.3 and 15mg/kg iv decreased markedly the early ischemic arrhythmia in conscious rats. Amiodarone 7.5mg?kg－1 had the same effects on the prevention of ischemic arrhythmia. In reperfusion experiment,it decreased the incidence of ventricalar fibrillation and significantly shortened the duration of arrhythmias. These results suggest that SA has protective effects on myocardial ischemia and reperfusion injury.