3.Expression of Toll-like receptors signaling pathway in chronic rhinosinusitis with nasal polyps
Xin WANG ; Chunyuan ZHAO ; Ming LIU
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2009;(23):1059-1062
Objective:To investigate the expression of Toll-like receptors(TLRs)signaling pathway in chronic rhinosinusitis(CRS)with nasal polyps.Method:Gene microarray analysis was used to detect the expression of TLRs signaling pathway in CRS with nasal polyps.Result:Of 19 differentially expressed(two-fold changes),4genes were upregulated and 15 genes were downregulated.Conclusion:The differentially expressed genes in TLRs signaling pathway may exert its effect in the pathogenesis of CRS.In addition,the roles of TLR9 and its agonists need further study.
5.Ultrasound - guided sclerosing therapy with injection of lauromacrogol for pelvic encapsulated hydrops:preliminary experience in 40 cases
Xin HE ; Zhongyang WANG ; Ming YIN
Journal of Interventional Radiology 2014;(6):503-505
Objective To investigate the clinical effect of ultrasound-guided sclerosing therapy with injection of lauromacrogol for the treatment of pelvic encapsulated hydrops. Methods A total of 40 patients with pelvic encapsulated hydrops were enrolled in this study. Under ultrasonographic guidance , puncture aspiration of pelvic encapsulated hydrops was carried out in all patients , which was followed by lauromacrogol injection of appropriate dose, and the drainage catheter was kept in the hydrops cavity. The clinical results were evaluated at one, 2 and 3 months after the treatment. Results The success rate of puncturing was 100%. Six months after the treatment, the complete cure was obtained in 86.4%of patients, and the effective rate was 100%. Conclusion For the treatment of pelvic encapsulated hydrops , ultrasound-guided sclerosing therapy with injection of lauromacrogol is effective and safe with instant result and lower recurrence rate. Therefore, this technique should be recommended in clinical practice.
6.Extended resection for locally advanced colorectal cancer.
Jian-ping WANG ; Xin-ming SONG
Chinese Medical Journal 2006;119(20):1675-1676
7.Application of color vision tests on the diagnosis and treatment for common ocular fundus diseases
Jie, SU ; Ming-Xin, AO ; Wei, WANG
International Eye Science 2016;16(8):1487-1491
?Color vision has been an important part of the human visual function.It is determined by the phytochrome of cone.In many clinical cases of ocular fundus diseases, patients had color vision loss, which shows that color visions tests is necessary and meaningful.At present, doctors have not paid attention to it and adopt the tests rarely. The article summarizes the tests of color in common use and applications on the diagnosis and treatment for common ocular fundus diseases to be a theory basis.
8.Experiment research of nifedipine and vitamin K3 on ureteral action potential and urine flow in rabbits.
Ming-Jiang WANG ; Xin-Jun WANG ; Gui-Xiang FENG
Chinese Journal of Applied Physiology 2007;23(1):50-65
Action Potentials
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Animals
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Female
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Male
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Nifedipine
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pharmacology
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Rabbits
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Ureter
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drug effects
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physiology
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Urination
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drug effects
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Vitamin K 3
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pharmacology
9.Exploration and demonstration study on drug combination from clinical real world.
Yan-ming XIE ; Lian-xin WANG ; Yong-yan WANG
China Journal of Chinese Materia Medica 2014;39(18):3424-3426
Drug combination is extensive in the clinical real world,which is an important part and the inherent requirements of the post-marketing evaluation of traditional Chinese medicine (TCM). The key issues and technology include multi-domain and multi-disciplinary such as the rationality, efficacy and safety evaluation of combination drug starting from clinical real world, study on component in vivo and mechanism of combination drug, the risk/benefit assessment and cost-benefit evaluation of combination drug and so on. The topic has been studied as clinical demonstration on combination therapy of variety of diseases such as coronary heart disease, stroke, insomnia, depression, hepatitis, herpes zoster, psoriasis and ectopic pregnancy. Meanwhile, multi-disciplinary dynamic innovation alliance of clinical drug combination has been presented, which can promote the academic development and improving service ability and level of TCM.
Drug Combinations
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Drugs, Chinese Herbal
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administration & dosage
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therapeutic use
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Humans
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Medicine, Chinese Traditional
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methods
10.A new tale of p21 activated protein kinase in the heart:pathophysiology to drug discovery
Shoubao WANG ; Hoyee TSUI ; Wei LIU ; Ming LEI ; Xin WANG
Chinese Journal of Pharmacology and Toxicology 2014;(4):475-483
CardiovascuIar disease is the number one cause for morbidity and mortaIity worIdwide. Possi-biIities for new therapies in the emerging fieId of cardiac signaIIing prompted extensive research on myocardiaI re-modeIIing over the past decades. In this review,we as-sembIe an overview of the recent findings on the muIti-functionaI enzyme,p21-activated kinase 1( Pak1),a member of a serine/ threonine protein kinase famiIy in the heart,particuIarIy its cardiac protective effects. We pres-ent a modeI for Pak1 signaIing that provides a mecha-nism for specificaIIy affecting cardiac ceIIuIar processes. We discuss its cardiac protective effects such as anti-hy-pertrophy,anti-ischaemic injury and roIe in maintaining ventricuIar Ca2+ homeostasis and eIectrophysioIogicaI stabiIity under physioIogicaI, β-adrenergic and hyper-trophic stress conditions.We aIso discuss the potentiaIs of Pak1 activation by naturaIIy occurring sphingosine and its anaIogues FTY720,and bioactive peptides designed to diminish Pak1 auto-inhibition as noveI thera-peutics for major cardiovascuIar diseases.