To study the Internet addiction disorder,262 college students were investigated by IAD Scale,Internet Usage Inventory,IAS Scale and Shyness Scale.The results showed:(1)Significant difference existed in IAD between freshman and Sophomore,between science and arts student.(2)Significant difference existed in the age of Internet use,on-line place,on-line time and the type of playing games.(3)College students'IAD is closely related to interaction anxiousness and shyness.

Nowadays,antiplatelet and anticoagulant drugs have been applied to a variety of cardiovascular diseases,such as atrial fibrillation and coronary artery disease.Several clinical studies show that there is a higher prevalence of gastrointestinal cancers in patients with cardiovascular disease.In addition,in patients taking antithrombotic drugs,positive fecal occult blood test (FOBT) improves the sensitivity for early detection of colorectal malignancies.This suggests that antithrombotic drugs may facilitate the detection of unrecognized cancers in patients with cardiovascular disease.However,there is no established evidence concerning whether more aggressive gastrointestinal tract screening will reduce the mortality of cancer in cardiology patients.But in an era of multiple antithrombotic drug usage,when patients appear unexplained anemia,gastrointestinal symptoms or positive FOBT,timely gastrointestinal tract screening is helpful to find concomitanted malignancies in these patients.

Signal transdcuers and activators of transcription3 (Stat3) is activated by a wide range of cytokines and growth factors following binding to special DNA domain and affects the expression of a variety of genes in modulating the process of cell proliferation, differentiation, and apoptosis. As a point of convergence for many oncogenic tyrosine kinase signaling pathways,it can be activited by sevral accesses. Stat3 is not only in-volved in the function of both apoptosis suppression,proliferation promotion,but also participates the process of angiogenesis,invasion and immune evasion. For repression of this way maybe a new target for break of cancer in-vasion and metastasis,blockers of Stat3 has become the focus of many researches.

Objective: To investigate the trends in cancer mortality among residents in Wuyi County, so as to provide insights into the development of the cancer control strategy. Methods: The deaths due to cancer among residents in Wuyi County from 2015 to 2019 were collected from Zhejiang Provincial Information Management System for Surveillance of Chronic Diseases. The crude mortality and standardized mortality of cancer and annual percent change (APC) of were calculated to analyze the trends in cancer mortality and causes of death. Results: A total of 3 424 deaths occurred due to cancer in Wuyi County from 2015 to 2019, and the crude and standardized mortality rates of cancer were 199.65/105 and 185.87/105, respectively. The crude mortality of cancer was significantly higher in men than in women (271.53/105 vs. 125.40/105;χ2=459.374, P<0.001). The standardized mortality of cancer showed a tendency towards a reduction among all study subjects, men and residents at ages of 45 to 59 years (APC=-3.87%, -4.44%,-11.46%, all P<0.05), and the crude mortality of cancer appeared a tendency towards a rise with age in all study subjects, men and women (χ2=7 063.842, 2 155.609, 5 492.128, all P<0.001). Lung cancer, liver cancer, gastric cancer, bowel cancer and esophageal cancer were the five leading causes of cancer-related mortality, which accounted for 71.41% of all cancer mortality. The crude mortality of central nervous system cancer (2.07/105) and leukemia (1.66/105) was high among residents at ages of 0 to 14 years, and the crude mortality of liver cancer (3.02/105) and lung cancer (2.01/105) was high among residents at ages of 15 to 44 years, while the crude mortality of lung cancer (51.57/105) and liver cancer (36.22/105)was high among residents at ages of 45 to 59 years, and the crude mortality of lung cancer (305.48/105) and gastric cancer (114.65/105) was high among residents at ages of 60 years and older. Conclusions The standardized mortality of cancer appeared a tendency towards a reduction in Wuyi County from 2015 to 2019, and men and the elderly were high-risk populations for cancer. Screening, early diagnosis and treatment of lung cancer, gastrointestinal cancer and cervical cancer should be given a high priority.

Objective To evaluate the effects of sevoflurane preconditioning on lung injury induced by renal ischemia-reperfusion (I/R) in rats.Methods Forty adult male Wistar rats,aged 3 months,weighing 200-250 g,were randomly divided into 5 groups (n =8 each):sham operation group (group S); renal I/R group (group I/R); 1.1％ sevoflurane preconditioning group (group SP1); 2.2％ sevoflurane preconditioning group (group SP2); and 3.3％ sevoflurane preconditioning group (group SP3).Renal I/R was induced by clamping bilateral renal pedicles for 45 min followed by 6 h reperfusion.In SP1-SP3 groups,1.1％,2.2％ and 3.3％ sevoflurane were inhaled for 1 h,respectively,before ischemia,followed by 10 min washout.The rats were sacrificed by exsanguination at 6 h of reperfusion,and lungs were removed for determination of wet/dry lung weight (W/D) ratio,myeloperoxidase (MPO) activity and expression of angiotensin converting enzyme (ACE) mRNA,and for microscope examination of pathologic changes which were scored.Results Compared with group S,the pathological score,W/D ratio,MPO activity and expression of ACE mRNA were significantly increased in I/R and SP1-SP3 groups (P ＜ 0.05).Compared with group I/R,the pathological score,W/D ratio,MPO activity and expression of ACE mRNA were significantly decreased in SP1-SP3 groups (P ＜ 0.05).Compared with SP1 and SP3 groups,the pathological score,W/D ratio,MPO activity and expression of ACE mRNA were significantly decreased in group SP2 (P ＜ 0.05).Compared with group SP1,the W/D ratio was significantly decreased (P ＜0.05),and no significant changes were found in the other parameters in group SP3 (P ＞ 0.05).Conclusion Sevoflurane preconditioning can attenuate lung injury induced by renal I/R and inhibition of ACE synthesis is involved in the mechanism.

Cerebral palsy (CP) is a essential disorder result in disability of children. Various treatments, especially rehabilitation, have been used and made some success for CP. This paper reviewed a number of literatures published last decade. The level of evidence and recommendation grade of various treatments was evaluated according to Cochrane.

Aim To establish a rat aortic calcification sub-chronic model induced by vitamin D3 and nicotine.Methods The vascular calcification model was produced by vitamin D3(300 kIU?kg-1,im) plus nicotine(25 mg?kg-1,5 ml?kg-1,po).Rat body weight and blood pressure were monitored on a regular basis.Ratio of heart to body weight,plasma calcium,plasma phosphate content,vascular calcium content,Von Kossa staining,activity of alkaline phosphatase(ALP) and 45Ca deposition in aorta were measured as the index of calcification at the 8th and the 16th week.Results Compared with control group,the VDN group rats showed higher values of blood pressure from the 3rd week(all P

Objective To investigate the electromyographic changes in the anterior temporal and masseter muscles of patients with long-term unilateral mandibular first molar loss. Methods Eighteen patients with one-year or more than one-year loss of unilateral mandibular first molar were selected as experimental group,and eighteen volunteers from similar places,had similar dietary habits in the same age and gender with normal occlusion were recruited as control group. Surface electromyography was used for the evaluation of the electrical activities of bilateral anterior temporal and masseter muscles in mandibular postural position ( MPP ) , maximal clenching in intercuspal position ( ICP) and masticating situations. The data were analyzed using SPSS 17. 0 software package to compare the differ-ences among groups. Results The average electrical activities of anterior temporal and masseter muscles in MPP of experimental group were significantly higher than the contral group,and the missing side was higher than the non-missing side ( P <0. 05 ) . The average electrical activities of anterior temporal and masseter muscles in maximal clenching and masticating were significantly lower than the control group,especially in the masticating situation( P<0. 05 ) . The asymmetry index of anterior temporal muscles and masseter muscles in MPP and maximal clenching were significantly different(P<0. 05). Conclusion Long-term loss of unilateral mandibular first molar can affect the electrical activities of the anterior temporal muscles and masseter muscles in the experimental group,especially for the missing side and in the masticating situation. These results also suggest that it might be one of the potential factors on mastication system disorders.

Infertility has become a global problem affecting human reproductive health.As an important treatment for infertility, assisted reproductive technology has made great progress over the past few decades.Rapid development has also taken place in medical devices for human assisted reproductive technology.It is imperative to establish the risk management and safety evaluation system of these products.In 2016, the industry standard YY/T 1434-2016 Human in vitro Assisted Reproductive Technology With Medical Equipment in vitro Mouse Embryo Test was officially released.In this paper, the key notes and elements of this in vitro mouse embryo test are briefly reviewed.

Along with the transformation of the pattern of the medicine and the development of dental medicine,more and more patients accept orthodontic treatment.The patients have higher expectations of the treatment.As a result,the abilities to make clinical communication for orthodontic postgraduates should be improved.The article discusses how to improve the orthodontic postgraduates' abilities in the hope that it will be of some help to them.