Coarctation of aorta is a discrete narrowness of the aorta and most commonly occurs in the isthmus.It is a common congenital cardiovascular malformation with morbidity of 5％ ～ 8％ among all congenital heart defects.Coarctation can result in the increase of upper limb blood pressure,the decrease of limb blood pressure,and a decline in cardiac function.Treatments include surgical repair and percutaneous interventions with different complications.Long-term complications and heart functions are important indices for evaluating prognosis and should be closely evaluated postoperatively.This review focuses on progresses of therapy methods,postoperative complications and cardiac function.

Objective To explore the spatial distribution of Keshan disease(KD) in the 15 surveillance provinces(municipalities,autonomous regions ) and to provide the basis for the development of prevention and control strategies.MethodsBased on the KD surveillance data of the 15 provinces in 2007,five indicators were selected.Moreover,a comprehensive indicator score to assess KD of different areas was made through the method of principle components analysis,which was applied for regionalization of the KD areas by the subsection method of standard deviation in whole China.The KD areas were divided into mild,moderate and severe endemic areas.The spatial distribution feature of the comprehensive indicator score was displayed by using geographic information system (GIS).ResultsThe three principal components contained 88.123％ information of all the selected indicators,the first principal component had a close relationship with total KD detection rate,chronic KD detection rate and latent KD detection rate; the second principal component had a close relationship with the threatened number in KD areas,and the third principal component had a close relationship with new KD detection rate; the comprehensive indicator indicates that Gansu,Jilin,Heilongjiang,Hebei,and Liaoning provinces were serious prevalent KD areas; Inner Mongolia,Shandong,Hubei,Sichuang provinces (autonomous region) were moderate prevalent KD areas,and Shanxi,Shaanxi,Yunnan,Henan,Guizhou,Chongqing provinces(municipality)were mild prevalent KD areas.Conclusions The introduction of the GIS to Keshan disease monitoring,provides a convenient and direct method to observe the spatial distribution of the disease,and the results point out the key areas for further KD surveillance according to local conditions.

By using traditional Chinese medicine inheritance support system to analyze the dominant experience and recessive principles of the prescriptions for stranguria in the dictionary of traditional Chinese medicine prescription (DCMP), we aim to define the medication pattern and rule and to acquire new prescriptions. In dominant experience analysis, we were able to find 22 drugs used over 50 times, including drugs of clearing heat, diuresis and relieving stranguria which are the most used and drugs of clearing heat, cooling blood, benefiting Qi and nourishing Yin. In addition, drugs of activating Qi and Xue, eliminating phlegm and removing toxic are often used, including 34 herb pairs and 5 combinations of three-taste drugs are used more than 35 times. These results fully reflect the composition principles and compatibility characteristic of prescriptions for treating stranguria in DCMP. Thirteen new prescriptions by way of recessive principle excavating were acquired. These new prescriptions might be suitable to clinical treatments of variable syndromes. This article provides an useful clue to research and produce new drugs.
Cluster Analysis ; Dictionaries as Topic ; Drug Prescriptions ; Humans ; Medicine, Chinese Traditional ; methods ; Urination Disorders ; drug therapy

In recent years,with the continuous development of endoscopic and interventional techniques,many new devices and methods have been used in clinical practice,and the application of endoscopic retrograde cholangiopancreatography (ERCP)in biliary and pancreatic diseases has developed rapidly.This paper reviews and summarizes the recent progress in ERCP among patients with biliary and pancreatic diseases,including those with altered gastrointestinal anatomy,pregnant patients,patients with benign and malignant biliary strictures,and patients with pancreatic pseudocysts,as well as the application of SpyGlass,photodynamic therapy,and radiofrequency ablation,the man-agement of ERCP-related duodenal perforation,and the prevention of post-ERCP pancreatitis.All the progress has made a great contribu-tion to the diagnosis and treatment of biliary and pancreatic diseases.

Metabolic syndrome, whose incidence is higher than that we have thought, has done great harm to people's health. This review is to introduce the recent advance in the defination,epidemiology,etiology,major risk factors,clinical diagnosis and treatment, etc . of metabolic syndrome.

The application of HPLC-NMR-MS hyphenated technique in the structural identification of trace substances from complex mixtures and the identification of endogenous and exogenous substances in the establishment process of metabolic profiling have become effective analytical tools in pharmaceutical chemistry, pharmacological and pharmacokinetic studies of active substances from natural products. Metabolomics method based on NMR technology can accurately portray metabolic phenotypes with the characteristics of diseases and a variety of disease-related pathways, and it can greatly enrich and supplement the traditional disease evaluation methods. So it can be used for pharmacological studies of active substances from natural products, such as toxicological studies, the dose optimization, active substances screening and pharmacodynamic evaluation. Hyphenated technique associated with metabolomics method based on NMR technology will accelerate the speed of the discovery of active substances from natural products, and improve the efficiency of their pharmacological evaluation.

Objective To study the clinical effect of Fuyankangfupian in the treatment of patients with miscarriage caused by chronic endometritis and its influence on the inflammatory factor.Methods A total of 80 patients with miscarriage caused by chronic endometritis were enrolled in this study.The subjects were randomly divided into control group (n =40) and observation group (n =40).The control group was treated with conventional treatment,the experiment group was treated with Fuyankangfupian combined with conventional treatment.The clinical indicators,the visual analogue scale (VAS),serum levels of TNF-α,hs-CRP and IL-2 of the two groups before and after treatment were recorded and compared.Results After treatment,the abdominal pain time [(2.96 ± 0.88) d],bleeding time [(4.51 ± 1.12) d] and blood loss [(102.16 ± 21.82) mL] of the observation group were significantly lower than those of the control group[(6.83 ± 1.32)d,(7.14 ± 1.50)d,(174.28 ±33.35) mL,t =15.428,8.885,11.445,all P ＜ 0.05].The VAS scores in the control group and observation group after treatment were (4.57 ± 0.79) points,(2.12 ± 0.41) points,respectively,which were significantly lower than those before treatment[(8.68 ± 1.40) points,(8.72 ± 1.38) points,t =16.170,28.995,all P ＜ 0.05],which of the observation group was significantly lower than that of the control group (t =17.409,P ＜ 0.05).After treatment,the serum levels of TNF-α and hs-CRP in the control group and observation group were (2.61 ± 0.20) pg/mL,(6.40 ± 1.36) mg/L and (1.13 ± 0.12) pg/mL,(3.01 ± 1.02) mg/L,respectively,which were significantly lower than those before treatment[(3.95 ±0.31) pg/mL,(11.35 ± 3.14) mg/L and (4.02 ± 0.35) pg/mL,(11.52 ± 3.20) mg/L,t =22.972,9.149,49.400,16.025,all P ＜0.05],while the serum levels of IL-2 of the two groups after treatment were (4.13 ± 0.75) μg/mL,(7.12 ±0.91) μg/mL,which were significantly higher than before treatment[(1.98 ±0.51) μg/mL,(1.87 ± 0.60) μg/mL,t =14.993,30.462,all P ＜ 0.05].The serum levels of TNF-α and hs-CRP of the observation group were significantlylower than those of the control group (t =40.132,12.612,all P ＜ 0.05),serum level of IL-2 of the observation group was significantly higher than that of control group (t =16.036,P ＜ 0.05).Conclusion Fuyankangfupian can significantly reduce the abdominal pain,bleeding time and blood loss,ease abdominal pain and inflammation of the patients with miscarriage caused by chronic endometritis,it is worthy clinical application.

[Objective]To study the influence of hydroxypropyl methyl cellulose(HPMC) on injectability of calcium phosphate cements(CPC).[Method]Calcium phosphate cement(ICPC) with different content of HPMC(0～4%) was prepared.Injectability coefficient and consistency were tested to evaluate the injectability of the cements.[Result]Injectability increased as HPMC content increased.CPC injectability coefficient reached to 95% with lowest consistency when HPMC increased to 2%.CPC with 2% HPMC could be injected from syringe completely.Injectability began decrease when HPMC beyond 3%.Injectability decreased to 90% as HPMC increased to 4%,2% HPMC increased the injectability and decreased the consistency significantly,without any influence of setting time.[Conclusion]Rheology and injectability of CPC can be improved by HPMC significantly,Injection of CPC with 2% HPMC can be used for mini-invasive orthopedic surgery.

The fracture of the axis arch is a rare uppercervical vertebrae fracture. It is easy to misdiag-nose. From 1971 to 1989, 7 cases of the fracturewere admitted to our hospital. Diagnoses were con-firmed by injury history, clinical features and X-ray films. The treatment results were as follows:six patients were in excellent condition and one pa-tient was in good one. The three following prob-lems were discussed: ①The mechanism of injury.②The misdiagnosis causes and its preventivemethods. ③Most patients can be treated conserva-tively and can be up. Only a few Type III fractureswill require operation after the failure of non-oper-ative treatment or at the time of conplicated injuryof the spinal cord occurring lately.