It is reported that zymogen granule membrane glycoprotein 2 (GP2 )and CUB and zona pellucida-like domain-containing protein 1 (CUZD1 )are the major autoantigens of autoantibodies against exocrine pancreas (PAB).GP2 is mainly expressed in the pancreatic acinar cell and M cells in small intestine follicle-associated epithelium,and CUZD1 is mainly expressed in uterus,ovary and pancreatic acinar cell.PAB is a relatively specific antibody for Crohn's disease (CD).The article reviewed the progress in study on autoantigens of PAB in CD.

ObjectiveTo Investigate the cervical cancer patients' knowledge and situation concerniug cervical cancer screening and explore the connection of cervical cancer screening status and clinical stage at diagnosis of cervical lesions.MethodsQuestionnaires were done for the cervical cancer patients who went to Peking University People's Hospital from February 2010 to October 2011.The patient's age,first visit or not,cause for treatment,awareness of cervical cancer now as well as that before diagnosis of the disease,the last cervical cancer screening' time and the clinical stage were recorded.The results of questionnaires were analyzed with SPSS 16.0.Results(1) One hundred and thirty-eight cases were collected and the average age was (48 ± 10) years old.Concerning the awareness level,the patients were divided into three groups of 10 points,5 points and 0 point based on the score of the second parts of the questionnaires.The number of the patients of the above three groups were 114 ( 82.6％ ),18 ( 13.0％ ) and 6 (4.3％ ) at present,while before the cancer diagnosis the number of the patients of the above three groups were 5 (3.6％),13 (9.4％) and 120 (87.0％).Patient's awareness level was much higher now than that before the cancer diagnosis(P ＜0.05 ).(2) Based on the last cervical cancer screening time,the patients were divided into four groups including within one year ( group 1 ),a year ago but within three years ( group 2),three years ago (group 3) and never done (group 4).There were 9 (6.5％) cases in group 1,30 (21.7％) cases in group 2,29 (21.0％) cases in group 3 and 70 ( 50.7％ ) cases in group 4.There were 5 (5/9)cases with stage Ⅰ a,3 (3/9)cases with stage Ⅰ b and 1 ( 1/9)case with stage Ⅱ or above in group 1;11 (36.7％,11/30) cases with stage Ⅰ a,15 (50.0％,15/30) cases with stage Ⅰ b and 4 (13.3％,4/30) cases with stage Ⅱ or above in group 2;5 (17.2％,5/29) cases with stage Ⅰ a,14 (48.3％,14/29 ) cases with stage Ⅰ b was and 10 ( 34.5％,10/29 )cases with stage Ⅱ or above in group 3;7 (10.0％,7/70) cases stage with Ⅰ a,35 (50.0％,35/70) cases with stage Ⅰ b and 28 (40.0％,28/70) cases with stage Ⅱ or above in group 4.The results showed that there was an increasing trend of advanced cervical carcinoma at diagnosis for the patients with longer last cervical cancer screening time (P ＜0.05 ).ConclusionsPeople's awareness level is much higher after being educated in cervical cancer.Among the cervical cancer patients,the probability of diagnosed patients with advanced cervical cancer has an increasing trend when their screening situation is poor.To raise the screening attendance rate among appropriate women,we should spread knowledge of cervical cancer to the population.

0 05) The radiotherapy and chemotherapy ratio of them was significantly higher than the control ( P 0 05). Multivariate analysis showed that the prognosis were related to the stage and tumor cell differentiation affected the prognosis remarkable But the prognosis was independent of age and associated medical disorders Conclusions The endometrial carcinoma often associates with hypertension, diabetes mellitus, coronary heart disease, and so on The incidence rate of medical disorders increases with the aging of the patients The medical disorders might affect the therapy to a certain extent But they do not affect the prognosis remarkably

31 rat were divided randomly into control group (n=10),tripterygium wilfordii glycosides group (n = 10 9. 4 mg/kg per day),and poly saccharide sulphate group (n=11. 30 mg/per day). We made balloon endothelium denudation in thoracic aortae of the rats. The treatments with drugs began 6 days before balloon injury and continously until the animal were killed 14 day after balloon injury. The determinations for area of neointima, neointima /media, coverage of neointima and 3H-TdR incoperation of thoracic aortae suggested that tripterygium wilfordii glycosides can inhibit intimal proliferation of injuried aorta, whill poly saccharide sulphate shows no effect.

Objective To observe the effect of Chinese medicine to wash, acupressure and Avene cream to moistur-ize for infantile eczema.Methods 100 babies who were diagnosed infantile eczema were chosen and separated to interven-tion group and control group randomly.The control group was treated by Chinese medicine to wash, acupressure and cream to moisturize, and the intervention group was treated by hormone medicine and Avene cream to moisturize.Observe the treat-ment effect after 7 days, 14days and 1 week after cured.Results The severity,effective rate and cure rate of two groups after 7days haven′t the statistical difference(p>0.05), and the severity of intervention group after 14days was lower than that of control group (p<0.05),the effective rate of intervention group after 14days was higher than and that of control group (p<0.05), and the recurrence rate of intervention group was lower than that of control group (p<0.05).Conclusion Combi-ning traditional Chinese and western medicine treatment can promote the treatment effect of infantile eczema , and reduce the recurrence, should be generalization.

Objective To investigate the effect of Hedan tablet combined with fluvastatin on serum LDL and heart rate variability in patients with coronary atherosclerotic heart disease (CHD).Methods 110 patients with coronary heart disease who were treated from March 2015 to June 2016 in our hospital were selected and randomly divided into observation group and control group, with 55 cases in each group.The patients in the observation group were treated with Hedan tablet combined with fluvastatin, and the control group was treated with fluvastatin.The changes of heart rate variability, blood lipids and inflammatory factors were compared before and after treatment, and the clinical curative effect was observed.Results After treatment, the total effective rate of the observation group was 96.4%, significantly higher than the control group 85.5%, the difference was statistically significant (P<0.05).The SDNN of the observation group was (85.42 ±9.11) ms and the SDANN was (49.11 ±5.13) ms, was significantly higher than those in the control group (76.87 ±8.12) ms, (44.16 ±4.76) ms.In the observation group, TC was (4.14 ±0.45) mmol/L, TG was (1.26 ±0.16) mmol/L, LDL was (2.08 ±0.31) mmol/L, significantly lower than the control group (4.78 ±0.51) mmol/L, (1.42 ±0.18) mmol/L, (2.43 ± 0.27) mmol/L, and HDL levels was (1.51 ±0.18) mmol/L, significantly higher than those in the control group (1.35 ±0.15) mmol/L, the difference was statistically significant (P<0.05), and the levels of inflammatory factors in the observation group were significantly lower than those in the control group, the difference was statistically significant (P<0.05).Conclusion Hedan tablets combined with fluvastatin in treating coronary atherosclerotic heart disease can effectively reduce serum LDL levels, improve heart rate variability, significantly improve the treatment effect.

Objective To investigate the effects of rosiglitazone on the cardiomyocyte apoptosis and expression of Bax and Bcl-2 in type 2 diabetic rats. Methods 8 weeks old SD rats were feeded with high calorie for one month, and then were intraperitoneally injected with a low dose of STZ (30mg/kg). The diabetic and control rats were killed at the 12th and 24th weeks after establishing model, respectively. Cardiomyocyte apoptosis was evaluated by TUNEL and flow cytometry. Flow cytometry was also used to detect the protein expression of Bax and Bcl-2. Results Compared with control group, apoptotic cells number, the Bax expression level and Bax/Bcl-2 ratio significantly increased in the diabetic rat hearts (P

Objective To evaluate the relationship of small heterodimer partner(SHP) gene and birth weight in China. Methods A cohort study of 191 normal pregnant women was conducted. Both maternal and cord blood samples were collected. PCR-RFLP was used to detect the polymorphism of SNP-rs7504 of SHP. Results (1) The frequency of both neonatal and maternal C allele and (TC+CC) genotype increased significantly with birth weight (P=0.004, OR=3.168; P=0.005, OR=3.315; P=0.013, OR=2.495; P=0.013, OR=2.495). (2) The babies were heavier if they were C allele carrier. The average increase of birth weight was 246.3 g comparing the neonates with TC+CC genotype with those with TT genotype [(3658.7?400.94)g vs (3412.4?444.4)g, P=0.005]. The average birth weight of those maternal C allele carriers was 210.3 g heavier than those non-C allele carriers[(3628.9?405.5) g vs (3418.6?449.0 g]. (3) The fetal C allele was associated with maternal weight in pregnancy, prepregnant BMI, paternal height and weight. Women with C allele were heavier and had higher BMI without statistical significance comparing with those non-C allele carriers. Neither neonatal nor maternal SHP gene was associated with blood glucose and insulin level. (4) Multiple factors analysis showed that birth weight was related to maternal height, weight gain during pregnancy, prepregnant BMI, maternal and cord blood insulin level. After adjustment, the neonatal birth weight remained significantly correlated with cord blood SHP (P=0.0354), but not with maternal SHP gene (P=0.0711). Conclusions SHP gene is associated with newborns birth weight and may affect fetal growth.

Objective To study curative efficacy of benazepril combined with atorvastatin on N-terminal pro-brain natriuretic peptide (NT-proBNP) and its efficacy in the treatment of chronic cardiac failure. Methods 90 patients of chronic heart failure were selected as research objects. The control group were treated with benazepril, while the observation group were treated with benazepril combined with atorvastatin, 45 cases in each group. Then before and after treatment of 6 months, the cardiac function of left ventricular end-diastolic dimension (LVEDD), left ventricular end systolic dimension (LVESD), left ventricular eject fraction (LVEF), C-reactionprotein (CRP), interleukin- 6 (IL-6, tumor necrosis factor α (TNF-α) and plasma NT-proBNP levels were compared between two groups, and the efficacy was observed. Results After treatment, LVEDD and LVESD in observation group were lower than those in control group, the LVEF was higher than that in control group(P<0.05). The CRP,IL-6 and TNF-αlevels in observation group were lower than those in control group(P<0.05). The plasma NT-proBNP level in observation group was significantly lower than that in control group(P<0.05). The total effective rate of observation group was statistically higher than that that in the control group 95.55%(43/45)vs. 77.77%(35/45)(P<0.05). Conclusion Benazepril combined with atorvastatin in the treatment of chronic heart failure is significant, can reduce plasma NT-proBNP levels, improve the inflammatory factor.

Objective: To make a retrospective control study of the curative effects of Four sacral needles method and conventional acupuncture therapy on female stress incontinence. Methods:A treatment group was treated by Four sacral needles method, in which four sacral points were electroacupunctured with special insertion of needles to excite the pudendal nerve and induce the rhythmic contraction of the pelvic floor muscles, thereby increasing the strength of the pelvic floor muscles and improving ability in urinary continence. A control group was treated by conventional acupuncture therapy, in which corresponding points were acupunctured according to syndrome-based classification. Results: In the 31 cases of the treatment group treated by Four sacral needlesmethod, 100% symptom improvement occurred in 22(71.0% )after an average of 21 treatments (3-63treatments). In the 34 cases of the control group treated by conventional acupuncture therapy, 100%symptom improvement occurred in 0 after 30 treatments. The curative effect was better in the treatment group than in the control group(p＜ 0.01).The curative effect improved with an increase in the number of treatments in the treatment group. Conclusion: Four sacral needles method is more effective than conventional acupuncture therapy in treating female stress incontinence.