Child ; Child, Preschool ; China ; Drug Therapy ; standards ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Infant ; Pediatrics ; Pharmacology, Clinical ; Pharmacovigilance ; Societies, Pharmaceutical

Minimal residual disease(MRD)iS the origin of relapse in leukemia.So it's significant to quantitate MRD in clinical.At present, there are three MRD quantitative assays, such as flow cytometric detection of abnormal immuno-phenotype,polymerase chain reaction(PCR)amplification of antigenreceptor genes and fusion transcripts.Because every measure has its own principle and feature.the clinical applications are different.Selecting suitable assays based on the characteristic of patients can help to quantitate MRD exactly.

BACKGROUND:Diabetes mel itus after kidney transplantation is an important metabolic complication of the transplanted organ, and seriously affects the quality of life and long-term survival rate of patients, which is a risk factor for renal al ograft dysfunction and cardiovascular disease. OBJECTIVE:To investigate the changes in fasting blood glucose and prognosis of patients who had survived more than 1 year after renal transplantation. METHODS:Total y 42 patients undergoing renal transplantation admitted at Xiantao First People’s Hospital from January 2003 to January 2013, including 7 cases of preoperative diabetes, 11 cases of impaired fasting glucose and 24 cases of normal fasting blood glucose. Fasting blood glucose levels were detected at 1, 7, 14 days and 1, 3, 6, 12 months after renal transplantation, and the survival conditions were also compared among different groups. Cox proportional hazard model was used to analyze influential factors of survival in patients undergoing renal transplantation. RESULTS AND CONCLUSION:The fasting blood glucose levels in the diabetes mel itus group were significantly higher than those in the impaired fasting glucose group and normal fasting blood glucose group before and after renal transplantation (P<0.05). The fasting blood glucose levels were increased in al the groups at 1 day after transplantation (P<0.05), and stabilized at 3 months after transplantation. The survival rate was significantly higher in the normal fasting blood glucose group than in the diabetes mel itus and impaired fasting glucose groups after renal transplantation (P<0.05). Cox proportional hazard model analysis showed that preoperative fasting blood glucose, age, postoperative tumor and infection were the independent risk factors for death in patients undergoing renal transplantation, among which, postoperative tumor led to the highest death risk ratio that was 2.376. Taken together, preoperative diabetes mel itus has some impacts on renal recipients who survive more than 1 year fol owing transplantation, but postoperative diabetes mel itus had no influence on the survival rate of the patients.

AKI is one of the frequent complications of critically ill patients,which is associated with high mortality.RRT is the main treatment,especially CRRT nowadays.But the optimal dosage of CRRT is unclear.In this article,we will review the evidence of CRRT in critically ill patients with AKI.Compared with traditional dosage of CRRT,high dose CRRT did not improve the clinical outcome.There was no difference in mortality rate,time for renal recovery,ICU hospitalization time,or organ failure in both groups,while there were more complications including hypokalemia and hypophosphatemia in the high dose CRRT group.Treatment with high dose CRRT could alter drug metabolism,cause malnutrition,unbalance the electrolyzes and cause hypothermia.So we conclude that traditional dosage of CRRT[20～35 mL/(kg?h)]is applicable for critically ill patients with AKI,but the determination of optimal dose depends on many clinical situations other than clearance of small solutes.

Vitamin D,an immune regulator,plays an important role in innate immune function of antibacterial peptide.Vitamin D takes part in the innate immune function via toll-like receptor in response to pathogen,then release antibacterial peptide.This study describes the antibacterial peptide constitution and the functions,effection of activeted Vitamin D in innate immune function of antibacterial peptide.

Education of the adolescent includes sexual physiological education,sexual psychological education and sexual moral education.of both the sexual psychological education and sexual moral deucation,which are often ignored,are the very important two aspects.

OBJECTIVE:To establish an HPLC method for determination of Emodin in Yanyan granules.METHODS:The stationary phase was Diamonsil C18(150mm? 4.6mm,5? m)column and the mobile phase was methanol-0.1% phosphoric acid(68∶ 32),with detection wavelength set at 254nm.RESULTS:Within the range of 0.26～ 3.90? g Emodin had a good linearity,and the average recovery was 96.73%(RSD=1.49%).CONCLUSION:The method is accurate,sensitive,reproducible,simple and can be used for the quality control of Yanyan granules.

Child ; Environmental Pollution ; Feeding Behavior ; Humans ; Lead ; pharmacokinetics ; Lead Poisoning ; diagnosis ; etiology ; Sanitation

Decorin( DCN) is one of the leucine-rich proteoglycan family of small molecules.It is recog-nized as a tumor suppressor gene.DCN can inhibit tumor cell proliferation and metastasis by binding and inactiva-tion of transforming growth factor beta( TGF-β) and inhibiting the expression of vascular endothelial growth fac-tor or by activating the signaling pathway that promotes cell proliferation by EGFR/MAPK/p21.it plays an impor-tant effect on tumor development,angiogenesis and metastasis.DCN is expressed in various malignant tumors,By up or down regulation,DCN can exert its anti tumor activity,as well as reducing or delaying the occurrence and development of many kinds of malignant tumor.DCN gene may be a potential target for the treatment of many kinds of malignant tumors.

OBJECTIVE:To investigate the characteristics and rules of leukocytopenia induced by essential antipsychotic medi-cines in psychotic in our hospital,and provide reference for the clinical treatment. METHODS:1 345 psychotics received essential antipsychotic medicines from Nov. 2012 to Nov. 2014 in our hospital were collected,and retrospective analysis was adopted to sta-tistically analyze the age,sex and the drug type,dose and treatment time that caused leukocytopenia,symptom duration,white blood cell(WBC)count,clinical manifestation and prognosis. RESULTS:In the 1 345 patients,there were 205 patients with WBC sustained reduction in the process of medication,accounting for 15.24%. The incidence rate of leukocytopenia in patients older than 60 years old reached up to 54.15%;57 patients with leukocytopenia was induced by combination medication,accounting for 20.14% in the total cases of combination medication,and it was significantly higher than the incidence rate of single medication (13.93%),the difference was statistically significant(P<0.05);incidence rate of leukocytopenia induced by the first generation of antipsychotic medicines was 63.36%,which was significantly higher than the second generation(36.64%),the difference was sta-tistically significant(P<0.05);there were 113 patients with the WBC count of 3.0×109-3.9×109 L-1,accounting for 54.63%,com-pared with other WBC count groups,there were significant differences(P<0.05);most of the patients had no discomfort and obvi-ous clinical symptoms,and all patients were improved or recovered after symptomatic treatment. CONCLUSIONS:The incidence rate of antipsychotic in elderly patients with essential antipsychotic medicines is relatively high,and the incidence of antipsychotic is more likely to be caused by combination medication and the first generation antipsychotic medicines. Although leukocytopenia can be cured,it may increase the risk of infection,so blood routine should be regularly checked and paid great attention during treatment.