Medullary thyroid carcinoma is a kind of neuroendocrine tumor that originates from calcitoninproducing parafollicular C-cells of the thyroid.Its incidence,diagnosis and treatment are unique.Ki67 is a nuclear antigen related to cell proliferation.It plays an important role in tumor occurrence and development,and it has important clinical significance in a variety of malignancies.Ki67 proliferation index has become classification index in neuroendocrine tumors of the gastrointestinal tract.In this paper,we review the study of medullary thyroid carcinoma and the expression of Ki67 in medullary thyroid carcinoma.

Objective To examine the association between baseline body mass index (BMI) and overall survival (OS) in lymph node negative breast cancer patients. Methods From Jan. 1st, 1998 to Dec. 30th, 2008, 662 patients with lymph node negative breast cancer were treated at the Breast Center of Peking University Peo-ple’s Hospital. The clinical factors such as menopause status, tumor stage, body mass index (BMI), total triglyc-eride (TG), total cholesterol (TC) and glucose (GLU) were collected. The chi-square test was used to assess the association between obese and other factors. Log-Rank test and Cox regression analysis were performed to make univariate and multivariate analysis. Results The median follow up was 82 months (ranging from 2 to 209 months). The 5-year and 10-year survival was 93% and 82%. Obesity was associated with GLU and tumor stage (χ2=5.224, P=0.031; χ2=6.007, P=0.14), whereas there was no relationship between obesity and other factors. The Log-Rank test revealed statistically significant better survival for non obesity (χ2=4.693, P=0.030), normal GLU (χ2=4.678, P=0.031) and HR positive patients (χ2=7.837, P=0.005). COX regression analysis showed that BMI (χ2=3.874, P=0.049) and HR status (χ2=6.782, P=0.030) had independent influence on overall survival of node negative breast cancer patients. Conclusion Obesity is an adverse prognostic factor for lymph node negative breast cancer patients, which may be associated with obesity-related disorders such as high blood GLU.

OBJECTIVE: To investigate the expression and clinical significance of Ki67 and calcitonin in medullary thyroid carcinoma(MTC). METHOD: The expression level of Ki67 and calcitonin was studied in 44 cases of medullary thyroid carcinoma tissue and 20 cases of adjacent nontumor tissue by SP immunohistochemistry. RESULT: The positive expression of Ki67 and calcitonin in medullary thyroid carcinoma tissue were 86.36% (38/44) and 100.00% (44/44) respectively. There was a significant difference between carcinoma and normal thyroid tissue (P<0.01). The overexpression of Ki67 and calcitonin in medullary thyroid carcinoma had no relationship with gender and age of patients,but had relationship with size of tumor,clinical staging and lymph node metastasis (P<0.05). Meanwhile, Ki67 and calcitonon had no significant correlation with each other. CONCLUSION The overexpression of Ki67 and calcitonin may play important role in occurrence, development and metastasis of medullary thyroid carcinoma. It may be used as an important judgement for the biological behavior of medullary thyroid carcinoma.
Calcitonin ; biosynthesis ; Carcinoma, Neuroendocrine ; Humans ; Ki-67 Antigen ; biosynthesis ; Lymphatic Metastasis ; Thyroid Neoplasms ; metabolism

Papillary thyroid microcarcinoma (PTMC) is defined as a papillary thyroid carcinoma measuring less than 10 mm in diameter. With the development of ultrasonic technology and the popularization of physical examination, the incidence of PTMC increased dramatically. Routine preoperative diagnostic methods include clinical examination, thyroid ultrasound and fine needle aspiration biopsy. But its treatment methods are still controversal. In this paper, we review literatures in recent years and discuss the clinical common problems of PTMC.
Biopsy, Fine-Needle ; Carcinoma ; diagnosis ; surgery ; Carcinoma, Papillary ; diagnosis ; surgery ; Humans ; Incidence ; Thyroid Cancer, Papillary ; Thyroid Neoplasms ; diagnosis ; surgery ; Thyroidectomy

Objective:Based on the level evaluation model of tuberculosis control established by analytic hierarchy process model, put forward the method of comprehensive evaluation of the quality of tuberculosis(TB) control and prevention work.Methods: The evaluation target of tuberculosis disease control and prevention was analyzed using analytic hierarchy process. At the same time, the weight of each evaluation index was established by the comparison of the pairwise comparison judgment matrix. And 3 TB control institutions in Beijing were evaluated.Results:Using this model, the comprehensive evaluation index of 3 TB control institutions was 65.6, 54.2 and 57.7 respectively.Conclusion: Analytic hierarchy process is a combination of qualitative and quantitative analysis. It is comprehensive, flexible and simple. At the same time, it is a good method for the evaluation of tuberculosis control and prevention in hospitals, and can be used as an effective tool for the management of tuberculosis control and prevention.

Objective To investigate the correlation between infertility and TORCH infections ,analyse the possible influence factors .Methods TORCH infections of 2343 cases of pregnant women and 1356 cases of infertility women were detected by chemi‐luminescence method ,the positive rates of TORCH‐IgM ,IgG were compared .Results RV ,HSV infections of infertility women were higher ,mainly in 30 -34 years group .TORCH infections of infertility women among seasons were of significant difference (P<0 .05) .TORCH infections of infertility women have correlations with schooling levels ,source of family ,and history of expo‐sure to animals (P<0 .05) .Conclusion The less education ,rural aera ,and history of exposure to animals were high risk factors of TORCH infections ,so screening for TORCH infections of infertility women is very necessary .

Objective To investigate the safety and clinical effect of laparoscopic radical parametrectomy in the treatment of unexpected cervical cancer . Methods A retrospective analysis was made on clinical characteristics of 15 patients who were diagnosed as unexpected cervical cancer from January 2008 to December 2014.The age of the patients was between 29 and 67 years old, with an average of 43.9 years old.The indications for hysterectomy were cervical intraepithelial neoplasia (CIN) grade 2-3 in 7 cases, uterine myoma in 3 cases, dysfunctional uterine bleeding in 2 cases, uterine prolapse in 2 cases and adenomyosis in 1 case. Pathological results after the hysterectomy included 13 cases of cervical squamous carcinoma and 2 cases of adenocarcinoma .The lesions were all confined to the cervix , with 4 cases of stage ⅠA2 disease and 11 cases of stage ⅠB1 .The lymph-vascular space invasion was found in 4 cases.The operation interval between the two operations was 3-7 d (mean, 4.6 d).They were all given laparoscopic radical parametrectomy . Results The operation time was 212-285 min (mean, 249.6 min), and the blood loss was 250-500 ml ( mean, 376 ml) .Postoperative pathological findings showed no residual disease .Only one patient had left pelvic lymph node mestastasis .Two patients had intraoperative complications , including 1 bladder injury and 1 ureteral injury .There were 3 cases of postoperative complications , including 2 cases of uroschesis and 1 case of lymphocyst .The follow-up time was 6-84 months ( median, 48 months).No recurrence was seen.The 1-, 3-, 5-year survival rates were 100%, 93.3%, 86.7%, respectively. Conclusions Laparoscopic radical parametrectomy in the treatment of unexpected cervical cancer is difficult to perform and has more complications . This surgical method is applicable to those who refused postoperation radiotherapy or required retaining ovarian function .

Objective To explore the association between the minimum temperature in different seasons and the hospital emergency room visits for cardiocerebrovascular diseases(International Classification of Diseases,tenth vision ICD-10:I00-I99) in Beijing,China.Methods The data of the daily hospital emergency room visits for cardiocerebrovascular diseases(ICD-10:I00-I99)from one of Peking university hospitals,the data of relevant ambient air pollution from the Beijing Municipal Environmental Monitoring Center and the data of meteorological index from China meteorological data sharing service system between 2004— 2006 were collected The time-stratified case-crossover design was used to analyze the data.Results After adjusting SO2,NO2,and PM10,the results showed that each 1 ℃ increase in the daily minimum temperature in summer was associated with the intraday hospital emergency room visits(OR=1.039,P

0.05) . Conclusion Air pollution can increase the risk of low birth weight and preterm birth in the exposed pregnant women.

Objective To explore the association between the daily maximum temperature and hospital emergency visits for cardiovascular and cerebrovascular diseases ( ICD-10: I00～I99) in different seasons in Beijing, China. Methods The data of the daily hospital emergency visits for cardiovascular and cerebrovascular diseases (ICD-10: I00～I99) from a Level-3A hospital in Haidian district in Beijing during 2004-2006 and the corresponding meteorological, air pollution data were collected. The seasonal-stratified case-crossover design and Logistic multiple regression model was used for the data analysis. Results After adjusting the influence of relative humidity, wind speed and atmospheric pressure, for 1℃ increase in daily maximum temperature, the corresponding increase in the hospital emergency visits of the diseases was 17.3%(OR=1.173, 95%CI:1.149～1.197) and 4.2% (OR=1.042, 95%CI: 1.011～1.074) in spring and summer of the years, respectively (P0.05). Conclusion The increase of daily maximum temperature may be a risk factor for daily hospital emergency visits for cardiovascular and cerebrovascular diseases in spring and summer, however, it may be a preventive factor in autumn. The effects of air temperature on health should not be the same in seasons.