Objective To investigate the causes and characteristic of placental abruption.Methods Clincal data of 52 patients with placental abruption were retrospectively analyzed.Results Compared with other incentives,gestational hypertension disease(especially in the severe group)had a significant difference (P ＜ 0.05),but in this group of materials due to placental premature rupture caused by placental abruption are light;on two groups of children to mode of delivery were compared,the difference was statistically significant (P ＜ 0.05) ;on two groups of maternal postpartum were compared,the difference was statistically significant (P ＜ 0.05) ; the two group of fetuses were compared,the difference was statistically significant(P ＜ 0.05).On 7 cases of fetal asphyxia of active treatment were cured.Conclusion In order to further reduce the incidence of placental abruption should the knowledge of this disease is caused take seriously,strengthen to the prevention of the disease as well as publicity and education,and further improve the prenatal diagnosis and treatment level,as the child 's life to provide security protection.

Bispheno|A(BPA)is an endocrine disruptor with estrgenic properties,which is a widely used industrial platicizer.When exposure to BPA for long-term,it would impact on multiple systems and organs including reproductive.developmental,neurological,endocrine function and so on,particularly in obesity.ExpoSUre to BPA during pregnancy and postnate,it can increase the sensitivity to obesity in offsprings.BPA may be contributed to obesity by enhancing triglyceride accumulation and accelerating adipocytes differentiation,affecting endocrine function of adipocytes and blood glucose and insulin metabolism.However,the dosage effect of BPA is not a simple linear rehionship.The impact of environment-related dosage on the human is worthy ot research in future.

In order to achieve the demand of clinical diagnosis,treatment and research based on TCM clinical literature,we conducted the questionnaire to doctors of Chinese medicine on their demands for medical information in the process of clinical diagnosis and treatment,hoping to make certain the direction and service methods of TCM clinical research database from the actual demands of doctors.

Age-related macular degeneration (AMD) can cause irreversible severe visual impairment.At present,a large number of basic and clinical research has documented several effective treatment for wet AMD.As for dry AMD,so far there is no effective therapy and preventive measure.Dry AMD probably worse for macular choroidal neovascularization (CNV) or geographic atrophy (GA) to its later stage,resulting in severe visual impairment.In recent years,some promising treatment strategies are emerging,mainly in the prevention of the damage of photoreceptor and retinal pigment epithelium,such as drug therapy,laser photocoagulation,surgery,plasma exchange,stem cell transplantation and gene therapy.These therapies are expected to be able to bring hope for arresting the development of dry AMD.This article reviews the current researches and possible future management of dry AMD.

Age-related macular degeneration (AMD) is the leading cause of the irreversible vision loss in population over 55 years of age.With the increasingly serious problem of aging,the prevalence of AMD is rising year by year.However,as the pathogenesis of dry AMD is largely unknown,the effective therapy still is lack.Given that there was a lack of proper animal models,it brought about obstacles to researches about molecular mechanism underlying dry AMD.Nowadays,lots of murine models of dry AMD have been established and developed,which provide suitable tools for relevant researches.But,different dry AM D models show varied pathogenesis features,and a reasonable choice of models is very important for different studies.The characteristics of different dry models were reviewed in this article.

Objective To investigate the prevalence of depression in hemodialysis patients with end‐stage renal disease(ESRD) , and evaluate its related factors .Methods One hundred and twenty four ESRD patients undergoing hemodialysis were assessed by using Beck depression inventory (BDI) .Baseline characteristics and laboratory test items were compared between depression group and non‐depression group .Results The prevalence of depression detected by BDI was 56 .5% in hemodialysis patients with ESRD . Gender and occupational status were statistically different between depression and non‐depression groups(P<0 .05) .Higher preva‐lence was found among female and non‐working patients .However ,there was no difference on age ,hemodialysis time ,education , marriage and incoming(P>0 .05) between the two groups .In laboratory test ,the white blood cell and urine acid levels in depression group were significant higher than that in the non‐depression group(P<0 .05) .Conclusion Depression is prevalent in ESRD pa‐tients undergoing hemodialysis ,especially in female and non‐working patients and always combined with higher white blood cells and urine acid levels .

Real-time three-dimensional echocardiography(RT-3DE) has been validated for its accurate diagnoses and quantitave mearsurement of mitral valve disease,which could act as a guide in selecting the proper therapeutic strategy for each individual in clinical setting.In this article,the recent research achievements on RT-3DE in mitral valve disease were summarized,and the application of RT-3DE in surgical approach to mitral valve disease was discussed as well.

Objective:To establish an HPLC method for the determination of two components in aspirin and phenobarbital pow-ders.Methods:AThermoBDSC18column(250mm×4.6mm,5μm)wasusedwithacetonitrile-methanol-0.01mol·L-1KH2PO4so-lution -triethylamine(10∶35∶55∶0.1)(adjusting pH to 3.5 with phosphoric acid )as the mobile phase. The flow rate was 1.0 ml· min-1 and the detection wavelength was 242nm. The column temperature was ambient and the injection volume was 20 μl. Results:There was a good linear relationship when the content of aspirin and phenobarbital was within the range of 0. 402 0 ~1. 608 0 mg· ml-1(r=0.999 7) and 0.061 2 ~0.244 8 mg·ml-1(r =0.999 6), respectively. The average recovery was 99.21%(RSD =0. 49%,n=9) and 99. 63% (RSD=0. 39%,n=9), respectively. Conclusion:The method is simple and accurate with good repro-ducibility, and can be used to control the quality of the preparation.

Up to 90 % of multiple myeloma patients can develop to osteolytic lesions. Although the conventional X radiography can only demonstrate the lytic bone disease when 30 % of the trabecular bone loss, it still remains the gold standard of the staging procedure of newly diagnosed myeloma patients. CT scans are more sensitive than X radiography for detecting small lytic lesions. MRI or CT is the choice of diagnosis to assess suspected cord compression. Technicium-99m bone scan in patients with myeloma usually underestimate the extent of bone damage. Treatments of myeloma bone disease include bisphosphonate therapy, novel targeted agents, surgical intervention and radiation therapy.

Collaborative inquiry applied in teaching of literature retrieval course is beneficial for the unity and cooperation between teachers and students,and their independent study ability. Described in this paper is the collabo-rative inquiry in teaching of information retrieval course with its target, methods and program carefully designed for medical postgraduates according to the students-oriented construction theory, which can promote the growth up of teachers and students, and learn the frontier and innovative theories, and practical knowledge.