Abstract Adolescent idiopathic scoliosis (AIS) is the most common spinal deformity. With increasing incidence in recent years, it has become an important public health problem threatening the health of adolescents. Adolescence is an important period for accelerated human growth and development, and endocrine hormones will change significantly during this period. Studies have shown that melatonin, estrogen, vitamin D and leptin are closely related to the production and development of scoliosis. Exploring the role of endocrine hormones in the pathogenesis of AIS can provide a reference for the prevention and treatment of AIS.

Children's sleep health runs through the entire process of children's growth and development and is of great significance.Sleep disorders are one of the important problems affecting children's grow，development and growth health.The number of pediatric patients with sleep disorders is on the rise year by year.Current studies show that the disturbance of children's sleep homeostasis is usually accompanied by the increase of neuroendocrine system activities，the activation of immune system，metabolic disorders，etc，lead to the corresponding hormones（such as cortisol），inflammatory factors，metabolic substances and other homeostasis changes，mutual influence，forming a vicious cycle.In addition，the relationship between genetic factors and sleep is also increasingly concerned.This article reviews the mechanisms，influencing factors and research progress of children's sleep health and sleep disorders，aiming to provide a reference for clinical intervention in children′s sleep problems.