When people are walking, they will produce gait signals and different people will produce different gait signals. The research of the gait signal complexity is really of great significance for medicine. By calculating people's gait signal complexity, we can assess a person's health status and thus timely detect and diagnose diseases. In this study, the Jensen-Shannon divergence (JSD), the method of complexity analysis, was used to calculate the complexity of gait signal in the healthy elderly, healthy young people and patients with Parkinson's disease. Then we detected the experimental data by variance detection. The results showed that the difference among the complexity of the three gait signals was great. Through this research, we have got gait signal complexity range of patients with Parkinson's disease, the healthy elderly and healthy young people, respectively, which would provide an important basis for clinical diagnosis.
Aged ; Gait ; Healthy Volunteers ; Humans ; Parkinson Disease ; physiopathology ; Reference Values ; Signal Processing, Computer-Assisted ; Walking

Aged ; Angiofibroma ; metabolism ; pathology ; Desmin ; metabolism ; Diagnosis, Differential ; Female ; Humans ; Inflammation ; Leiomyosarcoma ; pathology ; Neoplasms, Muscle Tissue ; metabolism ; pathology ; Vimentin ; metabolism ; Vulvar Neoplasms ; metabolism ; pathology

The quality of sleep has a great relationship with health and working efficiency. The result of sleep stage classification is an important indicator to measure the quality of sleep, and it is also an important way to diagnose and treat sleep disorders. In this paper, the method of detrended cross-correlation analysis (DCCA) was used to analyze sleep stage classification, sleep electroencephalograph signals, which were extracted from the MIT-BIH Polysomno graphic Database randomly. The results showed that the average DCCA exponent of the awake period is smaller than that of the first stage of non-rapid eye movement (NREM) sleeps. It is well concluded that the method of studying the sleep electroencephalograph with this method is of great significance to improve the quality of sleep, to diagnose and to treat sleep disorders.
Electroencephalography ; Humans ; Signal Processing, Computer-Assisted ; Sleep Stages

OBJECTVEThis study evaluates the expression of interleukin-18 (IL-18) and hypoxia-inducible factor (HIF)-lα in rat periodontitis model exposed to normoxia and chronic intermittent hypoxia (CIH) environments. The possible correlation between periodontitis and obstructive sleep apnea-hypopnea syndrome (OSAHS) was also investigated. Methods: Thirty-two Sprague-Dawley (SD) rats were randomly assigned into four groups: normoxia control, normoxia periodontitis, hypoxia control, and hypoxia periodontitis groups. The periodontitis models were established by ligating the bilateral maxillary second molars and employing high-carbohydrate diets. Rats in hypoxia control and hypoxia periodontitis groups were exposed to CIH treatment mimicking a moderately severe OSAHS condition. All animals were sacrificed after eight weeks, and the clinical periodontal indexes were detected. The levels of IL-18 and HIF-1α in serum and gingival tissues were determined using enzyme-linked immunosorbent assay (ELISA). The correlation between attachment loss (AL) and the levels of IL-18 and HIF-lα in hypoxia periodontitis group was evaluated.

RESULTSThe levels of IL-18 and HIF-lα in hypoxia periodontitis group were significantly higher than that in normoxia periodontitis and hypoxia control groups (P<0.05). Furthermore, the levels of IL-18 and HIF-lα in serum (r-0.792, r=0.753, P<0.05) and gingival tissues (r-0.817, r=0.779, P<0.05) were positively correlated with AL.

CONCLUSIONCIH could aggravate the destruction of periodontal tissues, which is correlated with IL-18 and HIF-lα levels.

Animals ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay ; Gingiva ; Hypoxia ; Hypoxia-Inducible Factor 1, alpha Subunit ; Interleukin-18 ; Periodontal Index ; Periodontitis ; Rats ; Rats, Sprague-Dawley ; Serum ; Sleep Apnea, Obstructive

Clinical data of 365 patients with type 2 diabetes admitted from December 2010 to May 2011 were retrospectively analyzed,including 130 cases with fatty liver and 235 non-fatty liver cases.There were no differences in gender,age,disease course between two groups (P ＞ 0.05). BMI,glycated hemoglobin (HbAlc),blood pressure,TC,TG,LDL-C,large vessels complications and microvascular complications rate in fatty liver group were significantly higher than those in non-fatty liver group ( all P ＜0.01 ),while there was no difference in rate of peripheral neuropathy (P ＞ 0.05 ).The results indicate that blood glucose,blood pressure,BMI,abnormal blood lipid and chronic complications were closely related to type 2 diabetics with fatty liver.

In this paper,we exhaustively discussed the teaching design of basic life support in processing teaching materials,choosing the methods of teaching and learning,planning the teaching process and reflection after teaching and so on,to introduce how to use the pedagogy and the psychology principles to guide teaching design,for the purpose of improving the teaching quality.

Objective To retrospectively review our experience of treating hepatic biloma in the elderly.Methods Before cyst fenestration,the fistulas between the bile duct and biloma were ligated in the 6 patients.Result All the 6 patients were cured.On follow-up,there was no recurrence.Conclusion The procedure is feasible and safe in the treatment of biloma in the elderly.

ObjectiveTo investigate whether brain microbleeds is associated with antiplatelet-related intracranial hemorrhage (ICH). MethodsForty-three patients with antiplatelet-related ICH treated in our hospital from Jun 2005 to Jun 2010 were investigated in this study.Age, sex and hypertension matched controls with non-antiplatelet-related ICH; and without history of ICH on antiplatelet therapy were selected. ResultsMicrobleeds was more frequent in antiplatelet users with ICH than in matched antiplatelet users without ICH(31/43(72. 1％ ) vs 12/57(21.1％ ), x2 =6. 731, P =0. 011 ) and was more frequent in IHC patients with antiplatelet treatment than those with non-antiplatelet treatment (31/43 (72. 1％ ) vs 17/48 (35.4％), P =0. 030). The frequency of lobar microbleeds(27/43, 62. 8％ ) was significant high in antiplatelet-related ICH than that in non antiplatelet-related ICH (19/48, 39. 6％, x2 =4. 019, P =0. 042). The number of microbleeds was associated with the risk of antiplate-related ICH ( OR =1.38 per additional microbleed, 95％ CI 1.07-1.71, t =0. 806, P =0. 021 ). ConclusionBrain microbleeds are associated with antiplatelet-related ICH.

Microbial genome reduction and modification are important strategies for constructing cellular chassis used for synthetic biology. This article summarized the essential genes and the methods to identify them in microorganisms, compared various strategies for microbial genome reduction, and analyzed the characteristics of some microorganisms with the minimized genome. This review shows the important role of genome reduction in constructing cellular chassis.
Genes, Essential ; genetics ; Genetic Engineering ; Genome, Microbial ; genetics ; Synthetic Biology ; methods

ObjectiveTo observe the changing of the level of high-sensitivity C-reactive protein level and serum lipids in elderly patients with early chronic kidney disease. Methods90 cases of early chronic kidney disease were collected and 90 cases without chronic kidney disease served as control.The levels of total cholesterol(TC),triglyeride(TG),high density lipoprotein(HDL),low density lipoprotein(LDL)and high-sensitivity C-reactive protein (hs-CRP)were measured. ResultsThere was significant difference between early chronic kidney disease group and the control group on TG,HDL and hs-CRP(all P＜0.05).The level of HDL in study group was significantly lower than those in control group(P＜0.05＝. ConclusionThe patients with early chronic kidney disease often had hypertriglyceridemia,declining HDL and elevating hs-CRP.It should be paid attention early.