Prospective study was carried out on 31 patients with severe hypertension treated in Vietnam Heart Institute. Those subjects were treated with intravenously LOXEN in the first 10 hours, measured blood pressure by the Holter. Results: nicardipin (LOXEN) is calci channel blocker with a good antihypertensive effect in treatment of severe hypertension. At initial dose 7.5 - 8.0 mg/hour, after the sixth minute, the drug had effect of antihypertention (p<0.05), at the 18th minute, blood pressure reduced by15%. At the normal dose 2-3 mg/hour by the time of 1, 4 and 10 hour, blood pressure gradually decreased and reached 16%, 22% and 24%, respectively compared to initial blood pressure. Nicardipin is easy to use and well tolerate, there was no patients with allergy or died of the medicament
Hypertension ; Therapeutics