Neurofibromatosis type 1 (NF1) is an autosomally dominant tumor suppressor syndrome and multisystem disease. Central giant-cell granulomas (CGCGs) can be seen in patients with NF1. A 21-year-old female was diagnosed with two CGCGs, one in the mandible and then one in the maxilla, in a 7-year period. Increased incidence of CGCGs in NF1 patients was thought to be caused by an underlying susceptibility to developing CGCG-like lesions in qualitatively abnormal bone, such as fibrous dysplasia. However, germline and somatic truncating second-hit mutations in the NF1 gene have been detected in NF1 patients with CGCGs, validating that they are NF1-associated lesions. Oral manifestations in patients with NF1 are very common. Knowledge of these manifestations and the genetic link between NF1 and CGCGs will enhance early detection and enable optimal patient care.

Background: Ever since the Dengvaxia controversy, vaccine confidence has plummeted in the Philippines, posing a problem for the COVID-19 vaccination program in the country [1,2]. With the impending COVID-19 pandemic, it is crucial to identify those who refuse vaccination, their perception about vaccines, and the immensity of their concerns [3]. Objectives: This study aimed to measure and describe the perception and attitude of Filipino mothers regarding COVID-19 vaccination for themselves and their children. Methodology: This descriptive-correlational study had a total of 404 respondents who answered the adapted survey questionnaire. The data gathered were analyzed through descriptive statistics such as percentages and standard deviations, and correlated using T-test and Pearson product-moment correlation. Results: The majority of the respondents stated their reluctance to receive the COVID-19 vaccine for themselves (56.9%) and their children (55%) while more than a third stated their refusal of the said vaccine for themselves (35%) and their children (39.6%). The top reason for their refusal was the concern for potential side effects. An overwhelming proportion of the respondents perceived that local leaders would support COVID-19 vaccination. Moreover, those who heard negative feedback on vaccines still stated their willingness to accept it. The respondents generally had a positive attitude on COVID-19 vaccination in terms of its importance. Pearson correlation showed a high positive correlation (r=0.785, p<0.05) between attitude towards self- and child-vaccination. Conclusion Respondents had a general positive attitude towards COVID-19 vaccination. Respondents with a more positive attitude towards self-vaccination were likely to have a positive attitude towards child-vaccination for COVID-19.
Vaccines ; COVID-19