1.Serum 25(OH)D and lipid levels in Chinese obese and normal weight males before and after oral vitamin D supplementation.
Ji Chang ZHOU ; Yu Mei ZHU ; Ping GUO ; Zheng CHEN ; Feng Zhu XIE ; Xiao Li LIU ; Shan HE
Biomedical and Environmental Sciences 2013;26(10):801-807
OBJECTIVETo study the effect of oral vitamin D (VD) supplementation on VD status and serum lipid in Chinese obese and healthy normal-weight men.
METHODSTwenty-one obese men with their body mass index (BMI)>28 kg/m(2) served as an obese group and 22 healthy normal-weight men with their BMI<24 kg/m(2) served as a control group in this study. After they were given 50 000 IU of oral VD, once a week for 8 weeks, the serum 25-hydroxyvitamin D [25(OH)D] concentration was measured with an enzyme-immunoassay kit.
RESULTSAfter oral VD supplementation, the serum 25(OH)D concentration significantly increased from 46.1±9.1 nmol/L to 116.7±20.3 nmol/L in the obese subjects (P<0.01) and from 52.8±17.8 nmol/L to 181.3±30.2 nmol/L in the control ones (P=0.13). The serum high-density lipoprotein cholesterol (HDL-C) level was reduced within the normal reference range in the obese group. However, no significant change was observed in the level of other serum lipids (triglycerides, total cholesterol, and low-density lipoprotein cholesterol) in either of the two groups.
CONCLUSIONThe effect of high-dose oral VD supplementation is weaker on VD status in the obese group than in the control group. High-dose oral VD supplementation has no side effect on serum lipid level in obese and control groups.
Body Mass Index ; Dietary Supplements ; Humans ; Male ; Obesity ; blood ; Vitamin D ; blood ; Vitamin D Deficiency ; blood
2.Analysis of Vitamin D Status in Men Highly Exposed to Sunlight.
Rong Hua ZHANG ; Deng Hua HE ; Biao ZHOU ; Yi Bo ZHU ; Dong ZHAO ; Li Chun HUANG ; Gang Qiang DING
Biomedical and Environmental Sciences 2015;28(12):913-916
Adult
;
China
;
epidemiology
;
Humans
;
Male
;
Middle Aged
;
Sunlight
;
Vitamin D
;
blood
;
Vitamin D Deficiency
;
epidemiology
4.Vitamin D and Hypertension.
Hye Yun JEONG ; Kyung Mi PARK ; Mi Jung LEE ; Dong Ho YANG ; Sang Hoon KIM ; So Young LEE
Electrolytes & Blood Pressure 2017;15(1):1-11
Vitamin D has the pleiotropic effects in multiple organ systems, and vitamin D deficiency was suggested to be associated with high blood pressure according to previous reports. Several interventional studies have examined the effect of vitamin D supplementation on high blood pressure patients, but the results have been inconsistent. In this article, we examined the literature that have proposed a mechanism involving vitamin D in the regulation of blood pressure and review previous observational and interventional studies that have shown the relationship between vitamin D and hypertension among various populations.
Blood Pressure
;
Humans
;
Hypertension*
;
Physiology
;
Vitamin D Deficiency
;
Vitamin D*
;
Vitamins*
6.The role of vitamin D in cancer prevention.
Rachel A NESS ; Duane D MILLER ; Wei LI
Chinese Journal of Natural Medicines (English Ed.) 2015;13(7):481-497
Vitamin D, also known as cholecalciferol, is the precursor to the active steroid hormone 1, 25-dihydroxyvitamin D3 (calcitriol; 1, 25(OH)2D3). The main physiological role for 1, 25(OH)2D3 is to regulate calcium and inorganic phosphate homeostasis for bone health. More recently, vitamin D has been investigated for its effects in the prevention and treatment of a variety of diseases such as cancer, autoimmune disorders, and cardiovascular disease. Preclinical data strongly support a role for vitamin D in the prevention of cancer through its anti-proliferative, pro-apoptotic, and anti-angiogenic effects on cells. Epidemiologic and clinical studies have shown mixed data on the correlation between serum vitamin D levels and cancer risk. This report seeks to outline results from the most recent preclinical and clinical studies investigating the potential role of vitamin D in cancer prevention.
Calcitriol
;
blood
;
Cholecalciferol
;
blood
;
Humans
;
Neoplasms
;
blood
;
etiology
;
prevention & control
;
Vitamin D
;
blood
;
Vitamin D Deficiency
;
blood
;
complications
7.Research advances in the role of vitamin D in autism spectrum disorders.
Ling SHAN ; Xiao-Lan HU ; Bing WANG ; Fei-Yong JIA
Chinese Journal of Contemporary Pediatrics 2016;18(2):183-188
The etiology and pathogenic mechanism of autism spectrum disorders (ASD) are still unclear. The relationship between vitamin D and ASD has drawn attention in recent years due to common vitamin D deficiency in children with ASD. This article reviews the peripheral blood levels of vitamin D in children with ASD, the possible reasons for hypovitamin D and its possible roles in the etiology of ASD and the efficacy of vitamin D supplementation in ASD.
Animals
;
Autism Spectrum Disorder
;
blood
;
drug therapy
;
Humans
;
Vitamin D
;
administration & dosage
;
blood
;
Vitamin D Deficiency
;
blood
;
drug therapy
8.Vitamin D level in children with bloodstream infection.
Hong-Ri LI ; Wei LI ; Lin-Ying GUO ; Xiao-Dai CUI ; Qi ZHANG ; Guo-Wei SONG
Chinese Journal of Contemporary Pediatrics 2016;18(3):215-218
OBJECTIVETo investigate the difference in serum 25(OH)D level between children with bloodstream infection and healthy children.
METHODSA case-control study was conducted among 60 children with bloodstream infection who were hospitalized between January 2010 and December 2013 and had positive results of two blood cultures. Meanwhile, 60 aged-matched healthy children who underwent physical examination during the same period of time were enrolled as the healthy control group. Chemiluminescence was applied to measure the serum 25(OH)D level, and the constituent ratios of children with different serum 25(OH)D levels were compared between the two groups.
RESULTSThe bloodstream infection group had a significantly lower serum 25(OH)D level than the healthy control group (P<0.01). Compared with the healthy control group, the bloodstream group had significantly lower constituent ratios of children with normal Vitamin D level (8% vs 35%) or vitamin D insufficiency (22% vs 43%) (P<0.05). Compared with the healthy control group, the bloodstream group had significantly higher constituent ratios of children with vitamin D deficiency (42% vs 13%) or severely vitamin D deficiency (28% vs 8%) (P<0.01).
CONCLUSIONSVitamin D insufficiency prevails among children, and children with bloodstream infection have a significantly lower serum 25(OH)D level than healthy children.
Case-Control Studies ; Child, Preschool ; Female ; Humans ; Male ; Sepsis ; blood ; Vitamin D ; analogs & derivatives ; blood ; Vitamin D Deficiency ; epidemiology
9.Correlation between neonatal vitamin D level and maternal vitamin D level.
Chen WANG ; Jin-Song GAO ; Song-Lin YU ; Ling QIU ; Lin ZENG ; Dan-Hua WANG
Chinese Journal of Contemporary Pediatrics 2016;18(1):20-23
OBJECTIVETo investigate the correlation between neonatal and maternal vitamin D levels.
METHODSFrom June 1 to July 10, 2015, umbilical venous blood samples were collected from 102 full-term single neonates, and venous blood samples were collected from their mothers. Ultra-performance liquid chromatography with isotope dilution was applied to measure the serum 25(OH)D level.
RESULTSVitamin D insufficiency was found in 39 mothers (38.2%) and 27 neonates (26.5%), and vitamin D deficiency was found in 25 mothers (24.5%) and 66 neonates (64.7%). Neonatal serum 25(OH)D level differed significantly between the groups of mothers with different serum 25(OH)D levels (P<0.001). Maternal 25(OH)D level was positively correlated with neonatal vitamin D level (r=0.914, P<0.001). When the receiver operating characteristic curve for maternal 25(OH)D level was used to predict neonatal vitamin D deficiency (≤15 ng/mL), the area under the curve was 0.962 (95%CI: 0.930-0.994; P<0.001). The sensitivity and specificity of maternal serum 25(OH)D level≤27.55 ng/mL to predict neonatal vitamin D deficiency were 97.2% and 80.3%, respectively.
CONCLUSIONSNeonatal vitamin D level is positively correlated with maternal vitamin D level. Maternal vitamin D level can help to predict neonatal vitamin D deficiency.
Adult ; Female ; Humans ; Infant, Newborn ; Male ; Pregnancy ; blood ; ROC Curve ; Vitamin D ; analogs & derivatives ; blood ; Vitamin D Deficiency ; diagnosis
10.Effects of cord blood vitamin D levels on the risk of neonatal sepsis in premature infants.
Birgul SAY ; Nurdan URAS ; Suzan SAHIN ; Halil DEGIRMENCIOGLU ; Serife Suna OGUZ ; Fuat Emre CANPOLAT
Korean Journal of Pediatrics 2017;60(8):248-253
PURPOSE: Vitamin D plays a key role in immune function. Vitamin D deficiency may play a role in the pathogenesis of infections, and low levels of circulating vitamin D are strongly associated with infectious diseases. In this study, we aimed to evaluate the effects of low vitamin D levels in cord blood on neonatal sepsis in preterm infants. METHODS: One hundred seventeen premature infants with gestational age of <37 weeks were enrolled. In the present study, severe vitamin D deficiency (group 1) was defined as a 25-hydroxyvitamin D (25(OH)D) concentration <5 ng/mL; vitamin D insufficiency (group 2), 25(OH)D concentration ≥5 ng/mL and <15 ng/mL; and vitamin D sufficiency (group 3), 25(OH)D concentration ≥15 ng/mL. RESULTS: Sixty-three percent of the infants had deficient levels of cord blood vitamin D (group 1), 24% had insufficient levels (group 2), and 13% were found to have sufficient levels (group 3). The rate of neonatal sepsis was higher in group 2 than in groups 1 and 3. CONCLUSION: There was no significant relationship between the cord blood vitamin D levels and the risk of neonatal sepsis in premature infants.
Communicable Diseases
;
Fetal Blood*
;
Gestational Age
;
Humans
;
Infant
;
Infant, Newborn
;
Infant, Premature*
;
Sepsis*
;
Vitamin D Deficiency
;
Vitamin D*
;
Vitamins*